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中华肺部疾病杂志(电子版) ›› 2019, Vol. 12 ›› Issue (01) : 63 -67. doi: 10.3877/cma.j.issn.1674-6902.2019.01.012

所属专题: 文献

论著

TIM-3-574G>T基因多态性与中国汉族人群支气管哮喘的相关性分析
梁卓政1, 郭程1, 孟平1, 李洪涛1, 张天托1,()   
  1. 1. 510630 广州,中山大学附属第三医院呼吸科
  • 收稿日期:2018-09-11 出版日期:2019-02-20
  • 通信作者: 张天托
  • 基金资助:
    广东省自然科学基金资助项目(2017A030313525)

Association between-574 G>T polymorphism of TIM-3 Gene and bronchial asthma in Chinese Han population: A meta analysis

Zhuozheng Liang1, Cheng Guo1, Ping Meng1, Hongtao Li1, Tiantuo Zhang1,()   

  1. 1. Department of Respiratory Medicine, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China
  • Received:2018-09-11 Published:2019-02-20
  • Corresponding author: Tiantuo Zhang
  • About author:
    Corresponding author: Zhang Tiantuo, Email:
引用本文:

梁卓政, 郭程, 孟平, 李洪涛, 张天托. TIM-3-574G>T基因多态性与中国汉族人群支气管哮喘的相关性分析[J]. 中华肺部疾病杂志(电子版), 2019, 12(01): 63-67.

Zhuozheng Liang, Cheng Guo, Ping Meng, Hongtao Li, Tiantuo Zhang. Association between-574 G>T polymorphism of TIM-3 Gene and bronchial asthma in Chinese Han population: A meta analysis[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2019, 12(01): 63-67.

目的

采用Meta分析评价T细胞免疫球蛋白黏蛋白域蛋白-3(TIM-3)-574 G>T(rs10515746)基因多态性与中国汉族人群支气管哮喘易感性的关系。

方法

检索中外文献数据库中TIM-3-574 G>T基因多态性与中国汉族人群支气管哮喘易感性关系的病例对照研究,末次检索时间为2017年12月20日。采用RevMan 5.0对TIM-3-574 G>T基因多态性与哮喘易感的显性模型OR值进行合并、敏感性分析和亚组分析,以及采用Stata对纳入文献的发表偏倚情况进行评估。

结果

共纳入5篇文献,其中病例组患者1 241例,对照组患者1 005例。Meta分析显示中国汉族人中TIM-3-574 G>T基因上突变型GT者的支气管哮喘发病风险较野生型纯合子GG者增加3.06倍(OR=4.06,95%CI:2.34,7.05),携带突变基因T者患支气管哮喘的风险比携带野生型G基因者增加3.31倍(OR=4.31,95%CI:2.50,7.43)。亚组分析显示携带GT基因型的成人和儿童患病风险均较纯合子GG高(儿童组:OR=4.07,95%CI:1.62,10.20;成人组:OR=3.09,95%CI:1.40,6.85)。

结论

T细胞免疫球蛋白黏蛋白域蛋白-3-574 G>T基因多态性与中国汉族人群支气管哮喘易感性有密切相关,突变T基因携带者患支气管哮喘的风险更高。

Objective

We performed the Meta-analysis to better investigate the association between-574 G>T genetic polymorphism of T cells immunoglobulin domain and mucin domain protein-3(TIM-3) and bronchial asthma(asthma) susceptibility in Chinese Han population.

Methods

Eligible case-control studies were searched from Chinese National Knowledge Infrastructure(CNKI), WanFang Database, SinoMed, Pubmed, Embase and Web of Science up to December. 20th 2017. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the potential association between-574 G>T variant of TIM-3 gene and asthma in dominant model by RevMan 5.3. This software was also used to perform sensitivity analysis and subgroup analysis. Additionally, publish bias can be well assessed by Stata 12.0.

Results

A total of five articles containing 1 241 asthma patients and 1 005 control subjects were included in our study. The risk of developing asthma in Asian population carried GT genotype is 306% higher than those who carried GG wild-type(OR=4.06, 95%CI: 2.34, 7.05). T allele carriers had a 331% increased risk to develop asthma compared with G allele carriers(OR=4.31, 95%CI: 2.50, 7.43). The result of subgroup analysis showed that both adults and children with GT genotype were more vulnerable to asthma than GG wild-type carriers(children group: OR=4.07, 95%CI: 1.62, 10.20; adults group: OR=3.09, 95%CI: 1.40, 6.85).

Conclusions

TIM-3-574 G>T polymorphism was associated with asthma susceptibility in Chinese Han population. T allele carriers had higher risk to develop asthma than wild-type carriers.

图1 Meta分析纳入文献筛选流程图
表1 Meta分析纳入的5篇文献基本信息特征
表2 5篇纳入文献中基因型和等位基因频率的分布特点[n(%)]
图2 TIM-3基因-574 G>T多态性与哮喘易感性(显性模型GT/GG)
图3 TIM-3基因-574 G>T多态性等位基因与哮喘易感性(位点比较模型G/T)
图4 TIM-3基因-574 G>T多态性与哮喘易感性的年龄亚组分析(显性模型GT/GG)
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