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中华肺部疾病杂志(电子版) ›› 2019, Vol. 12 ›› Issue (01) : 104 -107. doi: 10.3877/cma.j.issn.1674-6902.2019.01.024

所属专题: 文献

综述

转录因子EB调节机制的研究进展
范宜俊1, 刘伟2,()   
  1. 1. 710000 西安,空军军医大学(第四军医大学)基础医学院四大队
    2. 710000 西安,空军军医大学(第四军医大学)唐都医院呼吸与危重症医学科
  • 收稿日期:2018-12-13 出版日期:2019-02-20
  • 通信作者: 刘伟
  • 基金资助:
    国家自然科学基金资助项目(81600053)

Research progress on the regulatory mechanism of transcription factor Eb

Yijun Fan1, Wei Liu2()   

  • Received:2018-12-13 Published:2019-02-20
  • Corresponding author: Wei Liu
引用本文:

范宜俊, 刘伟. 转录因子EB调节机制的研究进展[J]. 中华肺部疾病杂志(电子版), 2019, 12(01): 104-107.

Yijun Fan, Wei Liu. Research progress on the regulatory mechanism of transcription factor Eb[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2019, 12(01): 104-107.

图1 mTORC1对TFEB的调控
1
Steingrimsson E,Copeland NG,Jenkins NA. Melanocytes and the microphthalmia transcription factor network[J]. Annu Rev Genet, 2014, 38: 365-411.
2
Napolitano G,Ballabio A. TFEB at a glance[J]. J Cell Sci, 2016, 129(13): 2475-2481.
3
Martina JA,Puertollano R. TFEB and TFE3: The art of multi-tasking under stress conditions[J]. Transcription, 2017, 8(1): 48-54.
4
Ballabio A. The awesome lysosome[J]. EMBO Mol Med, 2016, 8(2): 73-76.
5
Sardiello M,Palmieri M,di Ronza A, et al. A gene network regulating lysosomal biogenesis and function[J]. Science, 2009, 325(5939): 473-477.
6
Medina DL,Fraldi A,Bouche V, et al. Transcriptional activation of lysosomal exocytosis promotes cellular clearance[J]. Dev Cell, 2011, 21(3): 421-430.
7
Li Y,Ye X,Zheng X, et al. Transcription factor EB (TFEB)-mediated autophagy protects against ethyl carbamate-induced cytotoxicity[J]. J Hazard Mater, 2019, 364: 281-292.
8
Takahashi A,Takabatake Y,Kimura T, et al. Autophagy inhibits the accumulation of advanced glycation end products by promoting lysosomal biogenesis and function in the kidney proximal tubules[J]. Diabetes, 2017, 66(5): 1359-1372.
9
Liu F,Sun Q,Wang L, et al. Bioinformatics analysis of abnormal DNA methylation in muscle samples from monozygotic twins discordant for type 2 diabetes[J]. Mol Med Rep, 2015, 12(1): 351-356.
10
Liang J,Jia X,Wang K, et al. High expression of TFEB is associated with aggressive clinical features in colorectal cancer[J]. Onco Targets Ther, 2018, 11, 8089-8098.
11
He R,Shi X,Zhou M, et al. Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB[J]. Toxicol Appl Pharmacol, 2018, 356: 159-171.
12
Nezich CL,Wang C,Fogel AI, et al. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5[J]. J Cell Biol, 2015, 210(3): 435-450.
13
Uchida K,Unuma K,Funakoshi T, et al. Activation of Master Autophagy Regulator TFEB During Systemic LPS Administration in the Cornea[J]. J Toxicol Pathol, 2014, 27(2): 153-158.
14
Samie M,Cresswell P. The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways [J]. Nat Immunol, 2015, 16(7): 729-736.
15
高沿航. TFEB介导的溶酶体生物合成和自噬作用促进慢性乙醇诱导的小鼠肝脏损伤和脂肪变性[J]. 临床肝胆病杂志,2018, 34(10): 2156.
16
Sakamaki JI,Long JS,New M, et al. Emerging roles of transcriptional programs in autophagy regulation[J]. Transcription, 2018, 9(2): 131-136.
17
Settembre C,Zoncu R,Medina DL, et al. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB[J]. EMBO J, 2012, 31(5): 1095-108.
18
Settembre C,Di Malta C,Polito VA, et al. TFEB links autophagy to lysosomal biogenesis[J]. Science, 2011, 332(6036): 1429-1433.
19
Roczniak-Ferguson A,Petit CS,Froehlich F, et al. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis[J]. Sci Signal, 2012, 5(228): ra42.
20
Martina JA,Chen Y,Gucek M, et al. MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB[J]. Autophagy, 2012, 8(6): 903-914.
21
Vega-Rubin-de-Celis S,Pena-Llopis S,Konda M, et al. Multistep regulation of TFEB by MTORC1[J]. Autophagy, 2017, 13(3): 464-472.
22
Sancak Y,Bar-Peled L,Zoncu R, et al. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids[J]. Cell, 2010, 141(2): 290-303.
23
Zoncu R,Bar-Peled L,Efeyan A, et al. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase[J]. Science, 2011, 334(6056): 678-683.
24
Martina JA,Puertollano R. Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes[J]. J Cell Biol, 2013, 200(4): 475-491.
25
Zhang X,Cheng X,Yu L, et al. MCOLN1 is a ROS sensor in lysosomes that regulates autophagy[J]. Nat Commun, 2016, 7: 12109.
26
Medina DL,Di Paola S,Peluso I, et al. Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB[J]. Nat Cell Biol, 2015, 17(3): 288-299.
27
Benard G,Bellance N,James D, et al. Mitochondrial bioenergetics and structural network organization[J]. J Cell Sci, 2007, 120(Pt 5): 838-848.
28
Medina DL,Fraldi A,Bouche V, et al. Transcriptional activation of lysosomal exocytosis promotes cellular clearance[J]. Dev Cell, 2011, 21(3): 421-430.
29
Liu LH,Fan X,Xia ZK, et al. Angiotensin Ⅱ stimulates melanogenesis via the protein kinase C pathway[J]. Exp Ther Med, 2015, 10(4): 1528-1532.
30
Li Y,Xu M,Ding X, et al. Protein kinase C controls lysosome biogenesis independently of mTORC1[J]. Nat Cell Biol, 2016, 18(10): 1065-1077.
31
Saftig P,Haas A. Turn up the lysosome[J]. Nat Cell Biol, 2016, 18(10): 1025-1027.
32
Ferron M,Settembre C,Shimazu J, et al. A RANKL-PKCbeta-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts[J]. Genes Dev, 2013, 27(8): 955-969.
33
Palmieri M,Pal R,Nelvagal HR, et al. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases[J]. Nat Commun, 2017, 8, 14338.
34
Palmieri M,Pal R,Sardiello M. AKT modulates the autophagy-lysosome pathway via TFEB[J]. Cell Cycle, 2017,16(13): 1237-1238.
35
Song JX,Sun YR,Peluso I, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition[J]. Autophagy, 2016, 12(8): 1372-1389.
36
Li YY,Chen M,Wang J, et al. Quercetin ameliorates autophagy in alcohol liver disease associated with lysosome through mTOR-TFEB pathway[J]. J Functional Foods, 2019, 52.
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