| 1 | Rhodes A, Evans LE, Alhazzani W, et al. Surviving sepsis campaign:international guidelines for management of sepsis and septic shock: 2016[J]. Crit Care Med, 2017, 43(3): 486-552. | 
																													
																						| 2 | Goldenberg NM, Steinberg BE, Slutsky AS, et al. Broken barriers: a new take on sepsis pathogenesis[J]. Science Translational Med, 2011, 3(88): 88ps25-88ps25. | 
																													
																						| 3 | Ait-Oufella H, Maury E, Lehoux S, et al. The endothelium: physiological functions and role in microcirculatory failure during severe sepsis[J]. Intens Care Med, 2010, 36(8):1286-1298. | 
																													
																						| 4 | Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome[J]. Blood, 2003, 101(10): 3765-3777. | 
																													
																						| 5 | Hippenstiel S, Suttorp N. Interaction of pathogens with the endothelium[J]. Thromb Haemost, 2003, 89(1): 18-24. | 
																													
																						| 6 | Gianfranco B. Endothelial tight junctions: permeable barriers of the vessel wall[J]. Thromb Haemost, 2006, 96(1): 36-42. | 
																													
																						| 7 | 国家老年疾病临床医学研究中心(解放军总医院)  《感染诱发的老年多器官功能障碍综合征诊治中国专家共识》撰写组. 《感染诱发的老年多器官功能障碍综合征诊治中国专家共识》[J]. 中华老年多器官疾病杂志,2018, 17(1): 3-13. | 
																													
																						| 8 | Wu Q, Ren J, Wu X, et al. Recombinant human thrombopoietin improves platelet counts and reduces platelet transfusion possibility among patients with severe sepsis and thrombocytopenia: a prospective study[J]. J Crit Care, 2014, 29(3): 362-366. | 
																													
																						| 9 | Zakynthinos SG, Papanikolaou S, Theodoridis T, et al. Sepsis severity is the major determinant of circulating thrombopoietin levels in septic patients[J]. Crit Care Med, 2004, 32(4): 1004. | 
																													
																						| 10 | Segre E, Pigozzi L, Lison D, et al. May thrombopoietin be a useful marker of sepsis severity assessment in patients with SIRS entering the emergency department? [J]. Clin Chem Laboratory Med (CCLM), 2014: 1479-1483. | 
																													
																						| 11 | Lupia E, Bosco O, Mariano F, et al. Elevated thrombopoietin in plasma of burned patients without and with sepsis enhances platelet activation[J]. J Thromb Haemost, 2010, 7(6): 1000-1008. | 
																													
																						| 12 | Nawawi H, Osman NS, Annuar R, et al. Soluble intercellular adhesion molecule-1 and interleukin-6 levels reflect endothelial dysfunction in patients with primary hypercholesterolaemia treated with atorvastatin[J]. Atherosclerosis, 2003, 169(2): 283-291. | 
																													
																						| 13 | Tchinda VHM, Tadem AD, Tako EA, et al. Severe malaria in Cameroonian children: correlation between plasma levels of three soluble inducible adhesion molecules and TNF-α[J]. Acta Tropica, 2007, 102(1): 0-28. | 
																													
																						| 14 | Kaushansky K. Thrombopoietin[J]. N Engl J Med, 1998, 339(11): 746-754. | 
																													
																						| 15 | Van der Meeren A, Mouthon MA, Vandamme M, et al. Combinations of cytokines promote smvival of mice and limit acute aadiation damage in concert with amelioration of vascular damage[J]. Radiat Res, 2004, 161(5): 549-559. | 
																													
																						| 16 | Wu Q, Ren J, Wu X, et al. Recombinant human thrombopoietin improves platelet counts and reduces platelet transfusion possibility among patients with severe sepsis and thrombocytopenia: A prospective study[J]. J Crit Care, 2014, 29(3): 362-366. | 
																													
																						| 17 | Han JW, Kim KH, Kwun MJ, et al. Suppression of lung inflammation by the ethanol extract of Chung-Sang and the possible role of Nrf2[J]. BMC Complement Al tern Med, 2019, 19(1): 15. | 
																													
																						| 18 | Liu Z, Wang Y, Liu Y, et al. Typing of chronic ob structive pulmonary disease using high-resolution computed tomography and the association with smoking, arway inflammation,and common comorbidities[J]. Turk J Med Sci, 2018, 48(5): 945-951. | 
																													
																						| 19 | Cardier JE, Dempsey J. Thrombopoietin and its receptor, c-mpl, are constitutively expressed by mouse liver endothelial cells: evidence of thrombopoietin as a growth factor for liver endothelial cells[J]. Blood, 1998, 91(3): 923-929. | 
																													
																						| 20 | Stark AK, Sriskantharajah S, Hessel EM, et al. PI3K inhibitors in inflammation, autoimmunity and cancer[J]. Curr Opin Pharmacol, 2015, 23: 82-91. | 
																													
																						| 21 | Wang JY, Ye JY, Liang EY, et al. Thrombopoietin Prevents CoCl2-inducing Apoptosis of HUVEC through the PI3K/AKT Pathway[J]. J Exper Hematol, 2018, 26(2): 528. | 
																													
																						| 22 | Cheng HW, Chen YF, Wong JM, et al. Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway[J]. J Exper Clin Cancer Res, 2017, 36(1): 27. | 
																													
																						| 23 | Ramella R, Gallo MP, Spatola T, et al. A novel role of thrombopoietin as a physiological modulator of coronary flow[J]. Regulatory Peptides, 2011, 167(1): 5-8. | 
																													
																						| 24 | Chan KYY, Zhou L, Xiang P, et al. Thrombopoietin improved ventricular function and regulated remodeling genes in a rat model of myocardial infarction[J]. International Journal of Cardiology, 2013, 167(6): 2546-2554. | 
																													
																						| 25 | Baker JE, Su J, Koprowski S, et al. Thrombopoietin Receptor Agonists Protect Human Cardiac Myocytes from Injury by Activation of Cell Survival Pathways[J]. Journal of Pharmacology and Experimental Therapeutics, 2015, 352(3): 429-437. | 
																													
																						| 26 | Ilva T, Lund J, Porela P, et al. Early markers of myocardial injury: cTnI is enough[J]. Clinica Chimica Acta, 2009, 400(1-2): 0-85. | 
																													
																						| 27 | Grybauskiene R, Karciauskaite D, Brazdzionyte J, et al. Brain natriuretic peptide and other cardiac markers predicting left ventricular remodeling and function two years after myocardial infarction[J]. Medicina, 2007, 43(9): 708-715. | 
																													
																						| 28 | Singer M, Deutschman CS, Seymour CW, et al. The Third international consensus definitions for sepsis and septic shock (Sepsis-3)[J]. JAMA, 2016, 315(8): 801-810. | 
																													
																						| 29 | Rhodes A, Evans LE, Alhazzani W, et al. Surviving sepsis campaign:international guidelines for management of sepsis and septic shock: 2016[J]. Intensive Care Med, 2017, 43(3): 304-377. | 
																													
																						| 30 | Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign:international guidelines for management of severe sepsis and septic shock, 2012[J]. Intensive Care Med, 2013, 39(2): 165-228. |