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中华肺部疾病杂志(电子版) ›› 2022, Vol. 15 ›› Issue (05) : 715 -717. doi: 10.3877/cma.j.issn.1674-6902.2022.05.027

临床研究

支原体肺炎患儿肺泡灌洗液中sb7-h3、ifn-γ表达水平及临床意义
孙妮1, 徐丁1,(), 冉光会1   
  1. 1. 730000 甘肃,兰州大学第二医院儿科
  • 收稿日期:2022-04-11 出版日期:2022-10-25
  • 通信作者: 徐丁

Expression of sb7-h3 and ifn-γ in alveolar lavage fluid of children with mycoplasma pneumoniae and its clinical significance

Ni Sun1, Ding Xu1(), Guanghui Ran1   

  • Received:2022-04-11 Published:2022-10-25
  • Corresponding author: Ding Xu
引用本文:

孙妮, 徐丁, 冉光会. 支原体肺炎患儿肺泡灌洗液中sb7-h3、ifn-γ表达水平及临床意义[J]. 中华肺部疾病杂志(电子版), 2022, 15(05): 715-717.

Ni Sun, Ding Xu, Guanghui Ran. Expression of sb7-h3 and ifn-γ in alveolar lavage fluid of children with mycoplasma pneumoniae and its clinical significance[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2022, 15(05): 715-717.

目的

分析支原体肺炎患儿肺泡灌洗液中可溶性共刺激分子B7-H3(sB7-H3)、干扰素γ(IFN-γ)表达水平及临床意义。

方法

选取2018年9月至2020年9月我院收治的58例儿童肺炎支原体肺炎患儿,根据病程分为急性期为观察组22例和恢复期为对照组36例。对比两组患儿临床特征,采用Logistic多因素回归分析影响儿童肺炎支原体肺炎患儿的因素。

结果

观察组sB7-H3(152.39±19.02)(ng/L)、IFN-γ(63.57±9.82)(ng/L),较对照组sB7-H3(136.82±17.43)(ng/L)、IFN-γ(39.08±6.74)(ng/L),比较P<0.05。急性期组患儿呼吸衰竭、呼吸道反复感染构成比与恢复期组患儿比较,差异有统计学意义(P<0.05);Logistic多因素回归分析显示呼吸道反复感染、sB7-H3、IFN-γ均是儿童肺炎支原体肺炎患儿急性期的危险因素(OR=3.347,2.986,2.593,P<0.05);ROC分析显示,肺泡灌洗液中sB7-H3、IFN-γ表达水平预测儿童肺炎支原体肺炎患儿急性期的最佳截断点分别为147.50 ng/L和52.17 ng/L,灵敏度分别为82.14%和71.43%,特异度分别为76.56%和95.31%,曲线下面积(AUC)分别为0.801和0.828。

结论

儿童肺炎支原体肺炎患儿肺泡灌洗液中sB7-H3、IFN-γ表达均异常升高,二者均是儿童肺炎支原体肺炎患儿急性期的危险因素,二者为预测儿童肺炎支原体肺炎急性期具有临床意义。

表1 急性期与恢复期患儿临床特征
表2 儿童肺炎支原体肺炎自变量赋值
表3 Logistic多因素分析
表4 肺泡灌洗液sB7-H3、IFN-γ表达水平
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