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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (05) : 650 -653. doi: 10.3877/cma.j.issn.1674-6902.2023.05.009

临床研究

PD-1单抗治疗晚期非小细胞肺癌血清IL-27与预后相关性
魏晓辉, 苏智祥(), 陈文娟, 张燕军, 刘佳, 丁彩霞, 王云梅, 侯银银   
  1. 710061 陕西,陕西省肿瘤医院肿瘤内科
    710061 陕西,陕西省肿瘤医院胸外科
    710061 陕西,陕西省肿瘤医院病理科
  • 收稿日期:2023-04-02 出版日期:2023-10-25
  • 通信作者: 苏智祥
  • 基金资助:
    陕西省重点研发计划项目(2022SF-261)

Association of serum IL- 27 with prognosis in PD- 1 mAb treatment in advanced non-small cell lung cancer

Xiaohui Wei, Zhixiang Su(), Wenjuan Chen   

  • Received:2023-04-02 Published:2023-10-25
  • Corresponding author: Zhixiang Su
引用本文:

魏晓辉, 苏智祥, 陈文娟, 张燕军, 刘佳, 丁彩霞, 王云梅, 侯银银. PD-1单抗治疗晚期非小细胞肺癌血清IL-27与预后相关性[J/OL]. 中华肺部疾病杂志(电子版), 2023, 16(05): 650-653.

Xiaohui Wei, Zhixiang Su, Wenjuan Chen. Association of serum IL- 27 with prognosis in PD- 1 mAb treatment in advanced non-small cell lung cancer[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(05): 650-653.

目的

分析经程序性死亡受体1(programmed death 1, PD-1)单抗二线治疗晚期非小细胞肺癌(non-small cell lung cancer, NSCLC)血清白细胞介素(IL)-27与预后相关性。

方法

选择2019年6月至2022年4月我院收治的纳武单抗治疗晚期NSCLC患者107例。第1次注射纳武单抗前1 d,采用酶联免疫吸附实验(ELISA)测量基线血清IL-27水平,每2个治疗周期后评估治疗反应,8周内出现进展为早期进展者;获得部分反应或疾病稳定者为应答者。

结果

早期进展者基线血清IL-27水平低于应答者86.72(55.38,117.94)pg/ml vs. 184.41(116.81,273.29)pg/ml,Z=-5.329,P<0.001,预测早期进展者工作特征曲线下面积(AUC)0.829(95%CI:0.749~0.910,P<0.001)。基线血清IL-27水平与活检组织PD-L1表达正相关(r=0.523,P<0.001),与中性粒细胞计数(r=-0.402,P<0.001)、中性粒细胞和淋巴细胞比值(r=-0.343,P<0.001)、血清C反应蛋白水平(r=-0.309,P=0.001)、肺免疫预后指数(LIPI)(r=-0.247,P=0.010)负相关,与晚期肺癌炎症指数正相关(r=0.311,P=0.001)。年龄、基线血清IL-27水平是纳武单抗治疗晚期NSCLC患者OS的预后因素(P<0.05)。基线血清IL-27≤108.63 ng/ml的中位OS期短(P<0.05)。

结论

血清IL-27可能成为评估晚期NSCLC接受二线纳武单抗治疗具有临床意义。

表1 晚期NSCLC纳武单抗治疗反应单因素分析[n(%)]
表2 晚期NSCLC患者OS单因素和多因素COX回归分析
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