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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (05) : 721 -723. doi: 10.3877/cma.j.issn.1674-6902.2023.05.032

短篇论著

特发性肺纤维化合并T2DM炎症水平与预后相关性分析
谷先勇, 徐娟()   
  1. 231500 合肥,安徽省庐江县人民医院输血科
    231500 合肥,安徽省庐江县人民医院肿瘤科
  • 收稿日期:2023-02-09 出版日期:2023-10-25
  • 通信作者: 徐娟

Prognostic correlation analysis of idiopathic pulmonary fibrosis combined with T2DM inflammation level and prognosis

Xianyong Gu, Juan Xu()   

  • Received:2023-02-09 Published:2023-10-25
  • Corresponding author: Juan Xu
引用本文:

谷先勇, 徐娟. 特发性肺纤维化合并T2DM炎症水平与预后相关性分析[J/OL]. 中华肺部疾病杂志(电子版), 2023, 16(05): 721-723.

Xianyong Gu, Juan Xu. Prognostic correlation analysis of idiopathic pulmonary fibrosis combined with T2DM inflammation level and prognosis[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(05): 721-723.

特发性肺纤维化(idiopathic pulmonary fibrosis, IPF)是一种慢性进行纤维化间质性肺炎,好发于中老年男性,表现为进行性呼吸困难加重,伴限制性肺功能障碍,中位生存期2~3年[1]。吸烟、吸入性颗粒、胃食管反流等是IPF发生的危险因素[2]。糖尿病是IPF的危险因素,超过10%~42%的IPF合并糖尿病,糖尿病参与了IPF发病过程,确切机制尚未明了[3]。高血糖可能通过介导转化生长因子(transforming growth factor-β,TGF-β)、纤溶酶原激活物抑制剂-1(plasminogen activator inhibitor-1, PAI-1)、结缔组织生长因子(connectivetissuegrowthfactor, CTGF)等炎性介质,释放损伤肺泡-毛细血管网络及微血管内皮参与IPF发病过程[4]。高血糖通过炎症通路参与IPF的发生发展[5]。本文对我院收治的35例IPF合并2型糖尿病(diabetes mellitus type 2, T2DM)患者TGF-β、PAI-1、CTGF等炎症因子水平与预后相关性进行分析,报道如下。

表1 不同预后IPF合并T2DM单因素分析
表2 IPF合并T2DM预后多因素分析
1
刘雪娇,盛伟利,丁艳艳,等. 特发性肺纤维化急性加重患者预后危险因素及意义[J/CD]. 中华肺部疾病杂志(电子版), 2022, 15(2): 212-214.
2
Cottin Vincent, Bonniaud Philippe, Cadranel Jacques, et al. French practical guidelines for the diagnosis and management of idiopathic pulmonary fibrosis-2021 update. Full-length version[J]. Respir Med Res, 2023, 83: 100948.
3
Wang Dongguang, Ma Yao, Tong Xiang, et al. Diabetes mellitus contributes to idiopathic pulmonary fibrosis: A review from clinical appearance to possible pathogenesis[J]. Front Public Health, 2020, 8: 196.
4
Rajasurya Venkat, Gunasekaran Kulothungan, Surani Salim. Interstitial lung disease and diabetes[J]. World J Diabetes, 2020, 11(8): 351-357.
5
Bai Le, Zhang Li, Pan Tingyu, et al. Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review[J]. Respir Res, 2021, 22(1): 175.
6
姜 傥. 糖尿病的实验室诊断管理专家共识[J]. 临床检验杂志2020, 38(7): 481-487.
7
中华医学会呼吸病学分会间质性肺疾病学组. 特发性肺纤维化诊断和治疗中国专家共识[J]. 中华结核和呼吸杂志2016, 39(6): 427-432.
8
Hennegrave F, Le Rouzic O, Fry S, et al. Factors associated with daily life physical activity in patients with asthma[J]. Health Sci Rep, 2018, 1(10): e84.
9
王维越,姜晓艳. 糖尿病相关性肺纤维化的研究进展[J]. 国际呼吸杂志2014, 34(20): 1584-1588.
10
中华医学会呼吸病学分会间质性肺病学组,中国医师协会呼吸医师分会间质性肺疾病工作委员会. 特发性肺纤维化急性加重诊断和治疗中国专家共识[J]. 中华医学杂志2019, 99(26): 2014-2023.
11
付庭吕,高明朗,李 宁,等. 糖尿病肺纤维化发病机制的研究进展[J]. 中国药理学通报2022, 38(7): 961-964.
12
Navaratnam Vidya, Davis Timothy M E, Hubbard Richard, et al. Incidence and predictors of idiopathic pulmonary fibrosis complicating Type 2 diabetes: the fremantle diabetes study phase I[J]. Intern Med J, 2021, 51(2): 276-279.
13
Khateeb J, Fuchs E, Khamaisi M. Diabetes and lung disease: A neglected relationship[J]. Rev Diabet Stud, 2019, 15: 1-15.
14
Teague Taylor T, Payne Stephanie R, Kelly Bryan T, et al. Evaluation for clinical benefit of metformin in patients with idiopathic pulmonary fibrosis and type 2 diabetes mellitus: a national claims-based cohort analysis[J]. Respir Res, 2022, 23(1): 91.
15
Gribbin J, Hubbard R, Smith C. Role of diabetes mellitus and gastro-oesophageal reflux in the aetiology of idiopathic pulmonary fibrosis[J]. Respir Med, 2009, 103(6): 927-931.
16
Kim Yu Jin, Park Jeong-Woong, Kyung Sun Young, et al. Clinical characteristics of idiopathic pulmonary fibrosis patients with diabetes mellitus: the national survey in Korea from 2003 to 2007[J]. J Korean Med Sci, 2012, 27(7): 756-760.
17
Zhang YE. Non-smad signaling pathways of the TGF-β family[J]. Cold Spring Harb Perspect Biol, 2017, 9(2): a022129.
18
Rangarajan S, Bone NB, Zmijewska AA, et al. Metformin reverses established lung fibrosis in a bleomycin model[J]. Nat Med, 2018, 24(1): 1121-1127.
19
Li KC, Ho YL, Chen CY, et al. Lobeline improves acute lung injury via nuclear factor-κB-signaling pathway and oxidative stress[J]. Respir Physiol Neurobiol, 2016, 225: 19-30.
20
Massagué JoanSeoane Joan, Wotton David Smad transcription factors[J]. Genes Dev, 2005, 19(23): 2783-2810.
21
Chang Xuhong, Tian Minmin, Zhang Qiong, et al. Nano nickel oxide promotes epithelial-mesenchymal transition through transforming growth factor β1/smads signaling pathway in A549 cells[J]. Environ Toxico, 2020, 35(12): 1308-1317.
22
Kang HR, Lee CG, Homer RJ, et al. Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis[J]. J Exp Med, 2007, 204(5): 1083-1093.
23
Liu J, Wang Y, Pan Q, et al. Wnt/β-catenin pathway forms a negative feedback loop during TGF-β1 induced human normal skin fibroblast-to-myofibroblast transition[J]. J Dermatol Sci, 2012, 65(1): 38-49.
24
Evans Rachel Anna, Tian Ya Chung, Steadman Robert, et al. TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins[J]. Exp Cell Res, 2003, 282(2): 90-100.
25
Jiang Chunsun, Liu Gang, Luckhardt Tracy, et al. Serpine 1 induces alveolar type Ⅱ cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease[J]. Aging Cel, 2017, 16(5): 1114-1124.
26
Mohapatra A, Van Dyken SJ, Schneider C, et al. Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis[J]. Mucosal Immunol, 2016, 9(1): 275-286.
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