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中华肺部疾病杂志(电子版) ›› 2026, Vol. 19 ›› Issue (01) : 168 -172. doi: 10.3877/cma.j.issn.1674-6902.2026.01.028

综述

肺-骨轴及其在COPD并发骨质疏松症中的机制研究进展
田井梅1, 袁玉霞1, 李长桂2, 龙舟2, 杨聚豪2, 汪涓1,()   
  1. 1400037 重庆,陆军(第三)军医大学第二附属医院骨科
    2400037 重庆,陆军(第三)军医大学第二附属医院呼吸内科
  • 收稿日期:2025-12-19 出版日期:2026-02-25
  • 通信作者: 汪涓
  • 基金资助:
    重庆市社会科学规划项目(2023PY56); 护理科研培育课题(2022HLPY23)

Research Progress on the lung­bone axis and the mechanism in chronic obstructive pulmonary disease complicated with osteoporosis

Jingmei Tian, Yuxia Yuan, Changgui Li   

  • Received:2025-12-19 Published:2026-02-25
引用本文:

田井梅, 袁玉霞, 李长桂, 龙舟, 杨聚豪, 汪涓. 肺-骨轴及其在COPD并发骨质疏松症中的机制研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2026, 19(01): 168-172.

Jingmei Tian, Yuxia Yuan, Changgui Li. Research Progress on the lung­bone axis and the mechanism in chronic obstructive pulmonary disease complicated with osteoporosis[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2026, 19(01): 168-172.

慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)患者并发骨质疏松症(osteoporosis)患病率高,受到关注。尽管已知COPD并发骨质疏松症患者与糖皮质激素(glucocorticoid)应用、烟酒及运动等因素相关,但其机制尚未完全阐明。肺-骨轴(lung-bone axis)理论和概念的出现,肺与骨骼系统通过炎症介质、缺氧、维生素D代谢异常及激素调节等多通路形成的肺-骨间的联系得以逐步呈现。本文综述COPD并发骨质疏松症与肺-骨轴在相关的主要机制,包括系统性炎症、氧化应激、维生素D缺乏、糖皮质激素作用及内分泌激素失衡等,为COPD患者并发骨质疏松症的早期风险识别、分层管理及靶向精准干预的研究和临床实践提供参考,具有临床意义。

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