切换至 "中华医学电子期刊资源库"

中华肺部疾病杂志(电子版) ›› 2019, Vol. 12 ›› Issue (04) : 405 -408. doi: 10.3877/cma.j.issn.1674-6902.2019.04.001

专家论坛

非小细胞肺癌靶向治疗研究进展及新理念
吴国明1, 钱桂生1,()   
  1. 1. 400037,重庆,陆军军医大学(第三军医大学)新桥医院呼吸内科 全军呼吸内科研究所
  • 收稿日期:2018-05-18 出版日期:2019-08-20
  • 通信作者: 钱桂生

Research progress and new concept of targeted therapy for non-small cell lung cancer

Guoming Wu1, Guisheng Qian1()   

  • Received:2018-05-18 Published:2019-08-20
  • Corresponding author: Guisheng Qian
引用本文:

吴国明, 钱桂生. 非小细胞肺癌靶向治疗研究进展及新理念[J]. 中华肺部疾病杂志(电子版), 2019, 12(04): 405-408.

Guoming Wu, Guisheng Qian. Research progress and new concept of targeted therapy for non-small cell lung cancer[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2019, 12(04): 405-408.

1
钱桂生. 肺癌不同病理类型发病率的变化情况及其原因[J/CD]. 中华肺部疾病杂志(电子版), 2011, 4(1): 1-5.
2
吴国明,钱桂生. 应进一步加强对非小细胞肺癌靶向治疗的研究[J]. 中华医学杂志,2014, 94(30): 2321-2323.
3
Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2018[J]. CA Cancer J Clin, 2018, 68(1): 7-30.
4
Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma[J]. N Engl J Med, 2009, 361(10): 947-957.
5
中华医学会呼吸病学分会肺癌学组. 晚期非小细胞肺癌分子靶向治疗专家共识(2013版) [J]. 中华结核和呼吸杂志,2014, 37: 177-183.
6
Rosell R, Dafni U, Felip E, et al. Erlotinib and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF): an international, multicentre, single-arm, phase 2 trial[J]. Lancet Respir Med, 2017, 5(5): 435-444.
7
Seto T, Kato T, Nishio M, et al. Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study[J]. Lancet Oncol, 2014, 15(11): 1236-1244.
8
Cheng Y, Murakami H, Yang PC, et al. Randomized phase Ⅱ trial of gefitinib with and without pemetrexed as first-line therapy in patients with advanced nonsquamous non-small cell lung cancer with activating epidermal growth factor receptor mutations[J]. J Clin Oncol, 2016, 34(27): 3258-3266.
9
Nakamura A, Inoue A, Morita S, et al. Phase Ⅲ study comparing gefitinibmonotherapy (G) to combination therapy with gefitinib, carboplatin, andpemetrexed (GCP) for untreated patients (pts) with advanced nonsmall celllung cancer (NSCLC) with EGFR mutations (NEJ009) [J]. J Clin Oncol, 2018, 36: (suppl; abstr 9005).
10
Mok TS, Wu Y-L, Ahn M-J, et al. Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer[J]. N Engl J Med, 2017, 376(7): 629-640.
11
Soria JC, Ohe Y, Vansteenkiste J, et al. Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer[J]. N Engl J Med, 2018, 378(2): 113-125.
12
Cortinovis D1, Abbate M1, Bidoli P, et al. Targeted therapies and immunotherapy in non-small-cell lung cancer[J]. Ecancermedicalscience, 2016, 10: 648.
13
Thress KS, Paweletz CP, Felip E, et al. AcquiredEGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFRT790M[J]. Nat Med, 2015, 21(6): 560-562.
14
Chabon JJ, Simmons AD, Lovejoy AF, et al. Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients[J]. Nat Commun, 2016, 7: 11815.
15
Wang Y, Li L, Han R, et al. Clinical analysis by next-generation sequencing for NSCLC patients with MET amplification resistant to osimertinib[J]. Lung Cancer, 2018, 118: 105-110.
16
Wang X, Zhou L, Yin JC, et al. Lung Adenocarcinoma Harboring EGFR 19del/C797S/T790M Triple Mutations Responds to Brigatinib and Anti-EGFR Antibody Combination Therapy[J]. J Thorac Oncol, 2019, 14(5): e85-e88.
17
Zhong WZ, Wang Q, Mao WM, et al. Gefitinib versus vinorelbine plus cisplatin as adjuvant treatment for stageII-ⅢA (N1-N2) EGFR-mutant NSCLC (ADJUVANT/CTONG1104): a randomised, open-label, phase3study[J]. Lancet Oncol, 2018, 19(1): 139-148.
18
Yue D, Xu S, Wang Q, et al. Erlotinib versus vinorelbine plus cisplatin as adjuvant therapy in Chinese patients with stageⅢA EGFR mutation-positive non-small-cell lung cancer (EVAN): a randomised, open-label, phase2 trial[J]. Lancet Respir Med, 2018, 6(11): 863-873.
19
Solomon BJ, Mok T, Kim DW, et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer[J]. N Engl J Med, 2014, 371(23): 2167-2177.
20
Crystal AS, Shaw AT, Sequist LV, et al. Patient-derivedmodels of acquired resistance can identify effectivedrug combinations for cancer[J]. Science, 2014, 346(6216): 1480-1486.
21
Soria JC, Tan DSW, Chiari R, et al. First-line ceritinib versus platinum-based chemotherapy in advanced ALK-rearranged non-small-cell lung cancer (ASCEND-4): a randomised, open-label, phase 3 study[J]. Lancet, 2017, 389(10072): 917-929.
22
Peters S, Camidge DR, Shaw AT, et al. Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer[J]. N Engl J Med, 2017, 377(9): 829-838.
23
Camidge DR, Kim HR, Ahn MJ, et al. Brigatinib versus Crizotinib in ALK-Positive Non-Small-Cell Lung Cancer[J]. N Engl J Med, 2018, 379(21): 2027-2039.
24
Zou HY, Friboulet L, Kodack DP, et al. PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models[J].Cancer Cell, 2015, 28(1): 70-81.
25
Wang S, Yan B, Zhang Y, et al. Different characteristics and survival in non-small cell lung cancer patients with primary and acquired EGFR T790M mutation[J]. Int J Cancer, 2019, 144(11): 2880-2886.
26
Duruisseaux M, Besse B, Cadranel J, et al. Overall survival with crizotinib and next-generation ALK inhibitors in ALK-positive non-small-cell lung cancer (IFCT-1302 CLINALK): a French nationwide cohort retrospective study[J]. Oncotarget, 2017, 8(13): 21903-21917.
[1] 宋勇, 李东炫, 王翔, 李锐. 基于数据挖掘法分析3 种超声造影剂不良反应信号[J]. 中华医学超声杂志(电子版), 2024, 21(09): 890-898.
[2] 张静, 刘畅, 华成舸. 妊娠期患者口腔诊疗进展[J]. 中华口腔医学研究杂志(电子版), 2024, 18(05): 340-344.
[3] 汤宏涛, 何坤. 中晚期肝细胞癌介入治疗的进展及前景[J]. 中华普通外科学文献(电子版), 2024, 18(04): 305-308.
[4] 许月芳, 刘旺, 曾妙甜, 郭宇姝. 多粘菌素B和多粘菌素E治疗外科多重耐药菌感染临床疗效及安全性分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 700-703.
[5] 何羽. 腔镜微创手术治疗分化型甲状腺癌的研究进展[J]. 中华普外科手术学杂志(电子版), 2024, 18(04): 456-458.
[6] 赵淑樱, 张聃. 腹腔镜胃癌外科治疗进展与发展趋势[J]. 中华普外科手术学杂志(电子版), 2024, 18(04): 459-462.
[7] 谢汶歆, 马乐, 刘晔, 曹晓明, 张万春. 前列腺特异性膜抗原PET/CT在肾癌诊疗中的应用价值[J]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 514-519.
[8] 吴伟宙, 王琼仁, 詹雄宇, 郑明星, 李亚县. 广东省医学会泌尿外科疑难病例多学科会诊(第16期)——左肾肉瘤样癌[J]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 525-529.
[9] 李勇, 彭天明, 王倩倩, 陈育纯, 蒲小勇, 刘久敏. 基于失巢凋亡相关基因的膀胱癌预后模型构建及分析[J]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(04): 331-339.
[10] 李飞, 郑灶松, 吴芃, 谭万龙. 广东省医学会泌尿外科疑难病例多学科会诊(第16期)——延胡索酸水合酶缺陷型晚期肾细胞癌[J]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(04): 410-414.
[11] 赵蒙蒙, 黄洁, 余荣环, 王葆青. 过表达小GTP酶Rab32抑制非小细胞肺癌细胞侵袭性生长[J]. 中华肺部疾病杂志(电子版), 2024, 17(04): 512-518.
[12] 张桂萍, 丘勇林, 湛绮婷, 孙乐栋. 晚期非小细胞肺癌血清Ape1/Ref-1对放射性肺损伤发生的预测意义[J]. 中华肺部疾病杂志(电子版), 2024, 17(04): 519-523.
[13] 魏妙艳, 徐近. 合并远处转移胰腺癌系统性治疗的梳理和展望[J]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 644-650.
[14] 涂晓文. 糖尿病肾脏病的靶点药物研发进展[J]. 中华肾病研究电子杂志, 2024, 13(04): 240-240.
[15] 谭欣, 王鹏源, 胡良皞. 慢性胰腺炎抗炎和抗纤维化治疗的研究进展[J]. 中华消化病与影像杂志(电子版), 2024, 14(04): 289-296.
阅读次数
全文


摘要