切换至 "中华医学电子期刊资源库"

中华肺部疾病杂志(电子版) ›› 2019, Vol. 12 ›› Issue (04) : 515 -519. doi: 10.3877/cma.j.issn.1674-6902.2019.04.028

综述

靶向Toll样受体4治疗支气管哮喘的价值
王楠1, 王曦1, 高蕾1, 陈子1, 周林福2,()   
  1. 1. 210029 南京,南京医科大学第一附属医院呼吸与危重症医学科
    2. 210029 南京,南京医科大学第一附属医院呼吸与危重症医学科;210029 南京,南京医科大学中西医结合研究所;215228 苏州,南京医科大学附属江苏盛泽医院(江苏省人民医院盛泽分院)呼吸内科
  • 收稿日期:2019-05-13 出版日期:2019-08-20
  • 通信作者: 周林福
  • 基金资助:
    国家重点研发计划(2018YFC130103); 国家自然科学基金(81670029、81820108001、81670029); 江苏省医学重点人才项目(ZDRCA2016018); 江苏省社会发展重点研发专项(BE2015651); 江苏省研究生科研创新计划(KYCX171285)

Value of targeted Toll­like receptor 4 in the treatment of bronchial Asthma

Nan Wang1, Xi Wang1, Lei Gao1   

  • Received:2019-05-13 Published:2019-08-20
引用本文:

王楠, 王曦, 高蕾, 陈子, 周林福. 靶向Toll样受体4治疗支气管哮喘的价值[J]. 中华肺部疾病杂志(电子版), 2019, 12(04): 515-519.

Nan Wang, Xi Wang, Lei Gao. Value of targeted Toll­like receptor 4 in the treatment of bronchial Asthma[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2019, 12(04): 515-519.

1
Zhou LF, Zhang MS, Hu AH, et al. Selective blockade of NF-κB by novel mutated IκBα suppresses CD3/CD28-induced activation of memory CD4+ T cells in asthma[J]. Allergy, 2008, 63(5): 509-517.
2
Chen JQ, Szodoray P, Zeher M. Toll-Like receptor pathways in autoimmune diseases[J]. Clin Rev Allergy Immunol, 2016, 50(1): 1-17.
3
Crespo-Lessmann A, Mateus E, Vidal S, et al. Expression of toll-like receptors 2 and 4 in subjects with asthma by total serum IgE level[J]. Respir Res, 2016, 17: 41.
4
He M, Ichinose T, Song Y, et al. Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway[J]. Toxicol Appl Pharmacol, 2016, 296: 61-72.
5
Lee HY, Rhee CK, Kang JY, et al. Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma[J]. Korean J Intern Med, 2016, 31(1): 89-97.
6
Hosoki K, Itazawa T, Boldogh I, et al. Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation[J]. Curr Opin Allergy Clin Immunol, 2016, 16(1): 45-50.
7
Medzhitov R, Preston-Hurlburt P, Janeway CA, et al. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity[J]. Nature, 1997, 388(6640): 394-397.
8
Shi Z, Cai Z, Sanchez A, et al. A novel Toll-like receptor that recognizes vesicular stomatitis virus[J]. J Biol Chem, 2011, 286(6): 4517-4524.
9
Aryan Z, Rezaei N. Toll-like receptors as targets for allergen immunotherapy [J]. Curr Opin Allergy Clin Immunol, 2015, 15(6): 568-574.
10
Park BS, Song DH, Kim HM, et al. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex[J]. Nature, 2009, 458(7242): 1191-1195.
11
Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors [J]. Nat Immunol, 2010, 11(5): 373-384.
12
Kuramochi M, Izawa T, Pervin M, et al. The kinetics of damage-associated molecular patterns (DAMPs) and toll-like receptors during thioacetamide-induced acute liver injury in rats[J]. Exp Toxicol Pathol, 2016, 68(8): 471-477.
13
Pham DL, Yoon MG, Ban GY, et al. Serum S100A8 and S100A9 enhance innate immune responses in the pathogenesis of baker′s asthma[J]. Int Arch Allergy Immunol, 2015, 168(2): 138-146.
14
Di Candia L, Gomez E, Venereau E, et al. HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4[J]. J Allergy Clin Immunol, 2017, 140(2): 584-587.e588.
15
Ojo OO, Ryu MH, Jha A, et al. High-mobility group box 1 promotes extracellular matrix synthesis and wound repair in human bronchial epithelial cells[J]. Am J Physiol Lung Cell Mol Physiol, 2015, 309(11): L1354-1366.
16
Zhang H, Yang N, Wang T, et al. Vitamin D reduces inflammatory response in asthmatic mice through HMGB1/TLR4/NFkappaB signaling pathway[J]. Mol Med Rep, 2018, 17(2): 2915-2920.
17
Strachan DP. Hay fever, hygiene, and household size[J]. BMJ (Clinical research ed), 1989, 299(6710): 1259-1260.
18
Haapakoski R, Karisola P, Fyhrquist N, et al. Toll-like receptor activation during cutaneous allergen sensitization blocks development of asthma through IFN-γ -dependent mechanisms[J]. J Invest Dermatol, 2013, 133(4): 964-972.
19
Prefontaine D, Banville-Langelier AA, Fiset PO, et al. Children with atopic histories exhibit impaired lipopolysaccharide-induced Toll-like receptor-4 signalling in peripheral monocytes[J]. Clin Exp Allergy, 2010, 40(11): 1648-1657.
20
Bantz SK, Zhu Z, Zheng T. The Atopic March: progression from atopic dermatitis to allergic rhinitis and asthma[J]. J Clin Cell Immunol, 2014, 5(2): 202.
21
Chen L, Guo S, Ranzer MJ, et al. Toll-like receptor 4 has an essential role in early skin wound healing[J]. J Invest Dermatol, 2013, 133(1): 258-267.
22
Dickinson SE, Wondrak GT. TLR4-directed molecular strategies targeting skin photodamage and carcinogenesis[J]. Curr Med Chem, 2018, 25(40): 5487-5502.
23
Kemeny L, Szabo K. Toll-like receptors link atopic march to the hygiene hypothesis[J]. J Invest Dermatol, 2013, 133(4): 874-878.
24
Ryu JH, Yoo JY, Kim MJ, et al. Distinct TLR-mediated pathways regulate house dust mite-induced allergic disease in the upper and lower airways[J]. J Allergy Clin Immunol, 2013, 131(2): 549-561.
25
McAlees JW, Whitehead GS, Harley IT, et al. Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation[J]. Mucosal Immunol, 2015, 8(4): 863-873.
26
Mac Sharry J, Shalaby KH, Marchica C, et al. Concomitant exposure to ovalbumin and endotoxin augments airway inflammation but not airway hyperresponsiveness in a murine model of asthma[J]. PLoS One, 2014, 9(6): e98648-98659.
27
Nishihara F, Nakagome K, Kobayashi T, et al. Trans-basement membrane migration of eosinophils induced by LPS-stimulated neutrophils from human peripheral blood in vitro[J]. ERJ Open Res, 2015, 1(2). pii: 00003-2015.
28
Wang WL, Li HY, Zhang MS, et al. Thymic stromal lymphopoietin: a promising therapeutic target for allergic diseases[J]. Int Arch Allergy Immunol, 2013,160(1): 18-26.
29
Tjota MY, Hrusch CL, Blaine KM, et al. Signaling through FcRγ-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses[J]. J Allergy Clin Immunol, 2014, 134(3): 706-713.
30
Nembrini C, Sichelstiel A, Kisielow J, et al. Bacterial-induced protection against allergic inflammation through a multicomponent immunoregulatory mechanism[J]. Thorax, 2011, 66(9): 755-763.
31
Thorburn AN, Tseng HY, Donovan C, et al. TLR2, TLR4 and MyD88 mediate allergic airway disease (AAD) and streptococcus pneumoniae-induced suppression of AAD[J]. PLoS One, 2016, 11(6): e0156402.
32
Starkhammar M, Larsson O, Kumlien Georen S, et al. Toll-like receptor ligands LPS and poly (I︰C) exacerbate airway hyperresponsiveness in a model of airway allergy in mice, independently of inflammation[J]. PLoS One, 2014, 9(8): e104114.
33
Ullah MA, Loh Z, Gan WJ, et al. Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation[J]. J Allergy Clin Immunol, 2014, 134(2): 440-450.
34
周林福,胡志斌,谢 维,等. Toll样受体4基因多态性和内毒素在哮喘发病中的交互作用[J]. 中华医学杂志,2010, 90(2): 131-133.
35
Sahiner UM, Semic-Jusufagic A, Curtin JA, et al. Polymorphisms of endotoxin pathway and endotoxin exposure: in vitro IgE synthesis and replication in a birth cohort[J]. Allergy, 2014, 69(12): 1648-1658.
36
Sahin F, Yildiz P, Kuskucu A, et al. The effect of CD14 and TLR4 gene polymorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study[J]. BMC Pulm Med, 2014, 14: 20.
37
Zhang Q, Qian FH, Zhou LF, et al. Polymorphisms in toll-like receptor 4 gene are associated with asthma severity but not susceptibility in a Chinese Han population[J]. J Investig Allergol Clin Immunol, 2011, 21(5): 370-377.
38
Skovbakke SL, Franzyk H. Anti-inflammatory properties of antimicrobial peptides and peptidomimetics: LPS and LTA neutralization[J]. Methods Mol Biol, 2017, 1548: 369-386.
39
Pulido D, Garcia-Mayoral MF, Moussaoui M, et al. Structural basis for endotoxin neutralization by the eosinophil cationic protein[J]. FEBS J, 2016, 283(22): 4176-4191.
40
Menghini R, Campia U, Tesauro M, et al. Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis[J]. PLoS One, 2014, 9(6): e99053.
41
Paramo T, Tomasio SM, Irvine KL, et al. Energetics of endotoxin recognition in the Toll-like receptor 4 innate immune response[J]. Sci Rep, 2015, 5: 17997.
42
Kim Y, Lee H, Heo L, et al. Structure of vaccinia virus A46, an inhibitor of TLR4 signaling pathway, shows the conformation of VIPER motif[J]. Protein Sci, 2014, 23(7): 906-914.
43
Loyau J, Malinge P, Daubeuf B, et al. Maximizing the potency of an anti-TLR4 monoclonal antibody by exploiting proximity to Fcgamma receptors[J]. MAbs, 2014, 6(6): 1621-1630.
44
Cai B, Wang M, Zhu X, et al. The Fab fragment of a humanized anti-Toll like receptor 4 (TLR4) monoclonal antibody reduces the lipopolysaccharide response via TLR4 in mouse macrophage[J]. Int J Mol Sci, 2015, 16(10): 25502-25515.
45
杨 瑾,唐 奇,熊四平,等. 人源抗TLR4抗体IgG的制备及其中和特性分析[J]. 南京医科大学学报(自然科学版), 2015, 35(6): 777-781, 786.
46
Xiang Y, Eyers F, Herbert C, et al. MicroRNA-487b is a negative regulator of macrophage activation by targeting IL-33 production[J]. J Immunol, 2016, 196(8): 3421-3428.
47
Lochhead RB, Ma Y, Zachary JF, et al. MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi[J]. PLoS Pathog, 2014, 10(6): e1004212.
48
Thounaojam MC, Kundu K, Kaushik DK, et al. MicroRNA 155 regulates Japanese encephalitis virus-induced inflammatory response by targeting Src homology 2-containing inositol phosphatase 1[J]. J Virol, 2014, 88(9): 4798-4810.
49
Zhang F, Huang G, Hu B, et al. Anti-HMGB1 neutralizing antibody ameliorates neutrophilic airway inflammation by suppressing dendritic cell-mediated Th17 polarization[J]. Mediators Inflamm, 2014, 2014: 257930.
50
Zhang F, Huang G, Hu B, et al. Recombinant HMGB1 A box protein inhibits Th17 responses in mice with neutrophilic asthma by suppressing dendritic cell-mediated Th17 polarization[J]. Int Immunopharmacol, 2015, 24(1): 110-118.
51
Zhang Y, Xu T, Wu B, et al. Targeting myeloid differentiation protein 2 by the new chalcone L2H21 protects LPS-induced acute lung injury[J]. J Cell Mol Med, 2017, 21(4): 746-757.
52
Qin MZ, Gu QH, Tao J, et al. Ketamine effect on HMGB1 and TLR4 expression in rats with acute lung injury[J]. Int J Clin Exp Pathol, 2015, 8(10): 12943-12948.
53
Feng G, Sun B, Li TZ. Daidzein attenuates lipopolysaccharide-induced acute lung injury via toll-like receptor 4/NF-κB pathway[J]. Int Immunopharmacol, 2015, 26(2): 392-400.
54
Wu Z, Tan B, Zhang H, et al. Effects of sodium houttuyfonate on pulmonary inflammation in COPD model rats[J]. Inflammation, 2017, 40(6): 2109-2117.
55
Chen Z, Bai FF, Han L, et al. Targeting neutrophils in severe asthma via Siglec-9[J]. Int Arch Allergy Immunol, 2018, 175(1-2): 5-15.
[1] 马敏榕, 李聪, 周勤. 宫颈癌治疗研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 497-504.
[2] 林昌盛, 战军, 肖雪. 上皮性卵巢癌患者诊疗中基因检测及分子靶向药物治疗[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 505-510.
[3] 王璐, 樊杨. 子宫内膜癌相关生物标志物研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 511-516.
[4] 娄丽丽, 刘瀚旻. 儿童哮喘易感基因及表观遗传学研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(03): 249-255.
[5] 闫甲, 刘双池, 王政宇. 胆囊癌肿瘤标志物的研究和应用进展[J]. 中华普通外科学文献(电子版), 2023, 17(05): 391-394.
[6] 徐瑜杰, 赵国栋. 晚期胃癌治疗方法的研究进展和挑战[J]. 中华普外科手术学杂志(电子版), 2023, 17(04): 451-455.
[7] 王昆, 潘迪, 王庆, 江克华, 孙发. 机器人手术治疗膀胱副神经节瘤一例报告[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(03): 291-292.
[8] 邵浩仁, 郭佳. 铁死亡的分子机制及其在前列腺癌治疗中的研究进展[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(03): 294-298.
[9] 谭玲芳, 周克兵. 基于生物信息学整合鉴定与支气管哮喘相关的潜在诊断生物标志物[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 329-334.
[10] 路东明, 陈建华, 艾月琴. 布地格福吸入气雾剂治疗支气管哮喘的临床分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 361-363.
[11] 魏小勇. 原发性肝癌转化治疗焦点问题探讨[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 602-607.
[12] 吴晨瑞, 廖锐, 贺强, 潘龙, 黄平, 曹洪祥, 赵益, 王永琛, 黄俊杰, 孙睿锐. MDT模式下肝动脉灌注化疗联合免疫靶向治疗肝细胞癌多处转移一例[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 713-716.
[13] 吴寅, 陈智琴, 高勇, 权明. Her-2阳性结直肠癌的诊治进展[J]. 中华结直肠疾病电子杂志, 2023, 12(05): 420-425.
[14] 苗软昕, 乔晞. Toll样受体在脓毒症性急性肾损伤中的作用[J]. 中华肾病研究电子杂志, 2023, 12(04): 210-214.
[15] 刘天姿, 王宝军. Toll样受体4在阿尔茨海默病中的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(04): 404-409.
阅读次数
全文


摘要