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中华肺部疾病杂志(电子版) ›› 2021, Vol. 14 ›› Issue (02) : 201 -204. doi: 10.3877/cma.j.issn.1674-6902.2021.02.014

临床研究

血清hs-CRP、NGAL检测对脑卒中患者肺部感染预后临床意义
彭海莹1, 解翠环1   
  1. 1. 250031 济南,山东省立第三医院
  • 收稿日期:2020-08-15 出版日期:2021-04-25

Clinical significance of serum hs­CRP and NGAL in the prognosis of pulmonary infection in stroke patients

Haiying Peng1, Cuihuan Xie1   

  • Received:2020-08-15 Published:2021-04-25
引用本文:

彭海莹, 解翠环. 血清hs-CRP、NGAL检测对脑卒中患者肺部感染预后临床意义[J/OL]. 中华肺部疾病杂志(电子版), 2021, 14(02): 201-204.

Haiying Peng, Cuihuan Xie. Clinical significance of serum hs­CRP and NGAL in the prognosis of pulmonary infection in stroke patients[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2021, 14(02): 201-204.

目的

探讨血清超敏C反应蛋白(hs-CRP)、中性粒细胞明胶酶相关脂质蛋白(NGAL)联合检测对脑卒中后肺部感染预后临床分析。

方法

选取2018年10月至2020年9月我院收治的91例脑卒中并发肺部感染患者为对象。随访3个月,统计预后不良发生情况,分为预后不良组28例和预后良好组63例;对比患者的临床资料;Logistic多因素回归分析影响脑卒中患者肺部感染预后。分析联合检测血清hs-CRP、NGAL对脑卒中患者肺部感染预后不良的预测。

结果

脑卒中患者肺部感染预后不良发生率为30.76%(28/91)。预后不良组脑卒中重度/重度占比、病原菌多重耐药占比、空腹血糖、住院时间、收缩压、舒张压、WBC、NIHSS评分、血清hs-CRP及NGAL水平均显著高于预后良好组(P<0.05)。Logistic回归分析,多因素分析结果显示,白细胞计数(WBC)、血清hs-CRP及NGAL均为脑卒中患者肺部感染预后不良发生的影响因素(OR=2.765、3.499、3.766、4.289,P<0.05)。ROC分析显示,血清hs-CRP、NGAL预测脑卒中患者肺部感染预后不良的最佳截断点分别为20.02 mg/L、37.08 ng/ml,两者联合的特异度为95.12%,高于血清hs-CRP、NGAL单独进行评估的特异度(76.83%、68.29%),且血清hs-CRP、NGAL两者联合预测脑卒中患者肺部感染预后不良的曲线下面积(AUC)为0.841,显著高于血清hs-CRP、NGAL单独预测的AUC(0.662、0.729)。

结论

联合检测血清hs-CRP、NGAL对脑卒中患者肺部感染预后不良的预测有临床意义。

表1 两组临床资料对比(±s)
表2 影响脑卒中患者肺部感染预后Logistic回归分析
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