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中华肺部疾病杂志(电子版) ›› 2022, Vol. 15 ›› Issue (02) : 276 -278. doi: 10.3877/cma.j.issn.1674-6902.2022.02.038

综述

环状RNA在肺动脉高压发病机制中的研究进展
杨益1, 黄秋红1, 尤再春1,()   
  1. 1. 400037 重庆,陆军(第三)军医大学第二附属医院全科医学科
  • 收稿日期:2021-10-05 出版日期:2022-04-25
  • 通信作者: 尤再春
  • 基金资助:
    国家自然科学基金资助项目(81873413); 重庆市自然科学基金(cstc2018jcyjAX0098)

Research progress of circrnas in the pathogenesis of pulmonary hypertension

Yi Yang1, Qiuhong Huang1, Zaichun You1()   

  • Received:2021-10-05 Published:2022-04-25
  • Corresponding author: Zaichun You
引用本文:

杨益, 黄秋红, 尤再春. 环状RNA在肺动脉高压发病机制中的研究进展[J]. 中华肺部疾病杂志(电子版), 2022, 15(02): 276-278.

Yi Yang, Qiuhong Huang, Zaichun You. Research progress of circrnas in the pathogenesis of pulmonary hypertension[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2022, 15(02): 276-278.

1
Hoeper MM, Humbert M, Souza R, et al. A global view of pulmonary hypertension[J]. Lancet Respir Med, 2016, 4(4): 306-322.
2
Sommer N, Ghofrani H A, Pak O, et al. Current and future treatments of pulmonary arterial hypertension[J]. Br J Pharmacol, 2021, 178(1): 6-30.
3
Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats[J]. RNA, 2013, 19(2): 141-157.
4
Verduci L, Tarcitano E, Strano S, et al. CircRNAs: role in human diseases and potential use as biomarkers[J]. Cell Death Dis, 2021, 12(5): 1-12.
5
Kelly S, Greenman C, Cook PR, et al. Exon skipping is correlated with exon circularization[J]. J Mol Biol, 2015, 427(15): 2414-2417.
6
Ma S, Kong S, Wang F, et al. CircRNAs: biogenesis, functions, and role in drug-resistant Tumours[J]. Mol Cancer, 2020, 19(1): 1-19.
7
Eidem TM, Kugel JF, Goodrich JA. Noncoding RNAs: regulators of the mammalian transcription machinery[J]. J Mol Biol, 2016, 428(12): 2652-2659.
8
Liang ZZ, Guo C, Zou MM, et al. CircRNA-miRNA-mRNA regulatory network in human lung cancer: an update[J]. Cancer Cell Int, 2020, 20(1): 1-16.
9
Kramer MC, Liang D, Tatomer DC, et al. Combinatorial control of drosophila circular RNA expression by intronic repeats, hnRNPs, and SR proteins[J]. Genes Dev, 2015, 29(20): 2168-2182.
10
Aktas T, Avsar Ilik I, Maticzka D, et al. DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome[J]. Nature, 2017, 544(7648): 115-119.
11
Rong D, Sun H, Li Z, et al. An emerging function of circRNA-miRNAs-mRNA axis in human diseases[J]. Oncotarget, 2017, 8(42): 73271-73281.
12
Chen LL. The expanding regulatory mechanisms and cellular functions of circular RNAs[J]. Nat Rev Mol Cell Biol, 2020, 21(8): 475-490.
13
Huang A, Zheng H, Wu Z, et al. Circular RNA-protein interactions:functions, mechanisms, and identification[J]. Theranostics, 2020, 10(8): 3503-3517.
14
Zang J, Lu D, Xu A. The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function[J]. J Neurosci Res, 2020, 98(1): 87-97.
15
Shi Y, Jia X, Xu J. The new function of circRNA: translation[J]. Clin Transl Oncol, 2020, 22(12): 2162-2169.
16
Southgate L, Machado RD, Graf S, et al. Molecular genetic framework underlying pulmonary arterial hypertension[J]. Nat Rev Cardiol, 2020, 17(2): 85-95.
17
Li R, Jiang J, Shi H, et al. CircRNA: a rising star in gastric cancer[J]. Cell Mol Life Sci, 2020, 77(9): 1661-1680.
18
Zaiou M. CircRNAs signature as potential diagnostic and prognostic biomarker for diabetes mellitus and related cardiovascular complications[J]. Cells, 2020, 9(3):1-19.
19
Wang J, Zhao X, Wang Y, et al. CircRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma[J]. Cell Death Dis, 2020, 11(1): 1-11.
20
Wang Y, Zhao R, Liu W, et al. Exosomal circHIPK3 released from hypoxia-pretreated cardiomyocytes regulates oxidative damage in cardiac microvascular endothelial cells via the miR-29a/IGF-1 pathway[J]. Oxid Med Cell Longev, 2019, 2019: 7954657.
21
Zhang J, Li Y, Qi J, et al. Circ-calm4 Serves as an miR-337-3p sponge to regulate Myo10 (Myosin 10) and promote pulmonary artery smooth muscle proliferation[J]. Hypertension, 2020, 75(3): 668-679.
22
Yang L, Liang H, Meng X, et al. Mmu_circ_0000790 is involved in pulmonary vascular remodeling in mice with HPH via microRNA-374c-mediated FOXC1[J]. Mol Ther Nucleic Acids, 2020, 20: 292-307.
23
Wang J, Zhu MC, Kalionis B, et al. Characteristics of circular RNA expression in lung tissues from mice with hypoxiainduced pulmonary hypertension[J]. Int J Mol Med, 2018, 42(3): 1353-1366.
24
Zhou S, Jiang H, Li M, et al. Circular RNA hsa_circ_0016070 is Associated with pulmonary arterial hypertension by promoting PASMC proliferation[J]. Mol Ther Nucleic Acids, 2019, 18: 275-284.
25
Jin X, Xu Y, Guo M, et al. Hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension[J]. Mol Ther Nucleic Acids, 2021, 23: 1007-1019.
26
Ma C, Gu R, Wang X, et al. CircRNA CDR1as promotes pulmonary artery smooth muscle cell calcification by upregulating CAMK2D and CNN3 via sponging miR-7-5p[J]. Mol Ther Nucleic Acids, 2020, 22: 530-541.
27
Li Y, Zheng Q, Bao C, et al. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis[J]. Cell Res, 2015, 25(8): 981-984.
28
Guo J, Zhang L, Lian L, et al. CircATP2B4 promotes hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells via the miR-223/ATR axis[J]. Life sciences, 2020, 262: 1-9.
29
Miao R, Gong J, Zhang C, et al. Hsa_circ_0046159 is involved in the development of chronic thromboembolic pulmonary hypertension[J]. J Thromb Thrombolysis, 2020, 49(3): 386-394.
30
Dang RY, Liu FL, Li Y. Circular RNA hsa_circ_0010729 regulates vascular endothelial cell proliferation and apoptosis by targeting the miR-186/HIF-1alpha axis[J]. Biochem Biophys Res Commun, 2017, 490(2): 104-110.
31
Hong L, Ma X, Liu J, et al. Circular RNA-HIPK3 regulates human pulmonary artery endothelial cells function and vessel growth by regulating microRNA-328-3p/STAT3 axis[J]. Pulm Circ, 2021, 11(2): 1-11.
32
Liu W, Wang Y, Qiu Z, et al. CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-beta2 axis under hypoxia[J]. PeerJ, 2020, 8: 1-19.
33
Shan K, Liu C, Liu B H, et al. Circular noncoding RNA HIPK3 mediates retinal vascular dysfunction in diabetes mellitus[J]. Circulation, 2017, 136(17): 1629-1642.
34
Li Q, Tian Y, Liang Y, et al. CircHIPK3/miR-876-5p/PIK3R1 axis regulates regulation proliferation, migration, invasion, and glutaminolysis in gastric cancer cells[J]. Cancer Cell Int, 2020, 20: 1-12.
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