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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (01) : 1 -5. doi: 10.3877/cma.j.issn.1674-6902.2023.01.001

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肺动脉高压的成因及治疗新理念
任成山1, 卞士柱2,(), 胡明冬3,()   
  1. 1. 《中华肺部疾病杂志(电子版)》编辑部;400037 重庆,陆军(第三)军医大学第二附属医院消化内科
    2. 400037 重庆,陆军(第三)军医大学第二附属医院心血管内科CCU
    3. 400037 重庆,陆军(第三)军医大学第二附属医院老年医学与特勤医学科
  • 收稿日期:2023-01-10 出版日期:2023-02-25
  • 通信作者: 卞士柱, 胡明冬
  • 基金资助:
    国家自然青年基金资助项目(81901916); 国家重点研发计划(2020YFC2008900,2020YFC2008903)

New concept of the causes and treatment of pulmonary arterial hypertension

Chengshan Ren1, Shizhu Bian2(), Mingdong Hu3()   

  • Received:2023-01-10 Published:2023-02-25
  • Corresponding author: Shizhu Bian, Mingdong Hu
引用本文:

任成山, 卞士柱, 胡明冬. 肺动脉高压的成因及治疗新理念[J]. 中华肺部疾病杂志(电子版), 2023, 16(01): 1-5.

Chengshan Ren, Shizhu Bian, Mingdong Hu. New concept of the causes and treatment of pulmonary arterial hypertension[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(01): 1-5.

肺动脉高压(pulmonary hypertension, PH)是一种病理生理性疾病,涉及多种临床症状,与多种心血管和呼吸系统疾病相关。被称为一组"心、肺血管疾病中的破坏性疾病(destructive disease)",是一种罕见性疾病,PH的发病率从每年百万成人2.0~7.6例,患病率从每百万成年人11.0~26.0例不等[1,2]。经济发达国家的发病率和患病率分别为6.0例和48.0~55.0例百万成人[3]。但病死率较高,致病因素多,病理机制和临床分型复杂[4,5]。PH是一种以肺血管重构和肺血管阻力进行性增加为特征的血管炎症性疾病[6,7],为慢性、进行性、病死率高的疾病。不同类型PH具有相同临床特征,肺动脉内皮细胞和平滑肌细胞的过度增殖、抗凋亡和炎症导致肺小血管的渐进性增厚,引发肺血管的重构和肺血管阻力增加,最终导致右心室肥厚、心力衰竭,严重者则导致死亡[8,9,10,11]

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