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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (01) : 135 -137. doi: 10.3877/cma.j.issn.1674-6902.2023.01.038

病例报告

免疫联合化疗诱导治疗ⅢB期肺鳞癌二例
何杨1   
  1. 1. 241000 芜湖,皖南医学院第一附属医院弋矶山医院肿瘤内科
  • 收稿日期:2022-08-05 出版日期:2023-02-25

Two cases of induction therapy for ⅢB lung squamous cell carcinoma

Yang He1   

  • Received:2022-08-05 Published:2023-02-25
引用本文:

何杨. 免疫联合化疗诱导治疗ⅢB期肺鳞癌二例[J/OL]. 中华肺部疾病杂志(电子版), 2023, 16(01): 135-137.

Yang He. Two cases of induction therapy for ⅢB lung squamous cell carcinoma[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(01): 135-137.

肺鳞状细胞癌(squamous cell carcinoma of lung)是非小细胞肺癌(non-small cell lung cancer, NSCLC)常见病理类型之一,肺鳞癌驱动基因突变率低,目前缺乏安全有效的靶向治疗药物,临床治疗多以传统化疗药物为主[1]。近年来,免疫治疗在局部进展期和晚期驱动基因阴性非小细胞肺癌中表现出一定临床疗效[2]。肺鳞癌作为中国人群中最常见的基因突变类型,其中EGFR突变发生率为4%,ALK融合阳性率约为2%,这让更多肺鳞癌患者有机会从免疫治疗中获益[3,4]。本文对我院收治的2例ⅢB期无手术指征鳞癌患者免疫联合化疗的诱导治疗进行分析,报告如下。

图1 病例1胸部CT(肺窗)。注:A:治疗前,基线CT示左肺下叶病变;B:卡瑞利珠单抗联合化疗后CT示病灶较前明显缩小;C:末次随访CT示左肺术后改变,双肺间质性炎症
图2 病例2胸部CT(肺窗)。注:A:治疗前,基线CT示右肺中叶病变;B:卡瑞利珠单抗联合化疗后CT示病灶较前明显缩小;C:末次随访CT示右肺术后改变,残余右肺及左肺下叶少许炎症
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