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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (05) : 682 -684. doi: 10.3877/cma.j.issn.1674-6902.2023.05.019

临床研究

血清PLR与FIB对肺癌术后预后的预测意义
刘文龙(), 王杰, 彭杰, 李纯, 翟飞   
  1. 432400 孝感,应城市人民医院呼吸与危重症医学科
    432400 孝感,应城市人民医院胸外科
  • 收稿日期:2023-03-17 出版日期:2023-10-25
  • 通信作者: 刘文龙
  • 基金资助:
    湖北省卫生计生委科研项目(WJ2021Z0118)

Predictive significance of serum PLR and FIB on postoperative prognosis of lung cancer

Wenlong Liu(), Jie Wang, Jie Peng   

  • Received:2023-03-17 Published:2023-10-25
  • Corresponding author: Wenlong Liu
引用本文:

刘文龙, 王杰, 彭杰, 李纯, 翟飞. 血清PLR与FIB对肺癌术后预后的预测意义[J]. 中华肺部疾病杂志(电子版), 2023, 16(05): 682-684.

Wenlong Liu, Jie Wang, Jie Peng. Predictive significance of serum PLR and FIB on postoperative prognosis of lung cancer[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(05): 682-684.

目的

分析血清血小板/淋巴细胞比值(platelet lymphocyte ratio, PLR)与纤维蛋白原(fibrinogen, FIB)水平变化对肺癌术后预后的预测价值。

方法

选取2019年1月至2021年6月我院收治的肺癌患者71例,术前3日检测血清PLR、FIB值;根据ROC曲线确定界值,分为低PLR组25例与高PLR组46例、低FIB组28例和高FIB组43例;比较低PLR、FIB组与高PLR、FIB组水平差异;分析血清PLR、FIB与临床病理特征的关系,判断血清PLR、FIB变化对肺癌术后预后的影响。

结果

术前血清PLR、FIB低水平组和高水平组差异有统计学意义(P<0.05);术后血清PLR值低于术前(P<0.05);术前血清FIB值高于术后(P<0.05)。血清PLR、FIB低水平组生存率(52.00%、57.14%)高于高水平组(36.96%、39.53%)(P<0.05)。多因素分析显示,TNM Ⅲ期(HR=8.18,95%CI:5.038~20.106)、肿瘤低分化(HR=5.19,95%CI:2.716~10.926)、PLR(HR=3.18,95%CI:2.021~7.906)、FIB(HR=2.31,95%CI:1.210~9.152)是影响肺癌术后预后的危险因素(P<0.05)。

结论

血清PLR、FIB水平升高对肺癌术后预后的具有临床意义。

表1 血清PLR及FIB与肺癌临床病理的关系
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