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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (05) : 706 -708. doi: 10.3877/cma.j.issn.1674-6902.2023.05.027

临床研究

MR-proADM作为社区获得性肺炎预后生物标志物的临床分析
张黎黎, 杨敏, 石娅妮, 谭红霞()   
  1. 408000 重庆,重庆大学附属涪陵医院全科医学科
  • 收稿日期:2023-03-07 出版日期:2023-10-25
  • 通信作者: 谭红霞
  • 基金资助:
    重庆市科委联合计划项目(FLKJ2022ABB2105)

Clinical analysis of MR-proADM as a prognostic biomarker for community-acquired pneumonia

Lili Zhang, Min Yang, Yani Shi   

  • Received:2023-03-07 Published:2023-10-25
引用本文:

张黎黎, 杨敏, 石娅妮, 谭红霞. MR-proADM作为社区获得性肺炎预后生物标志物的临床分析[J/OL]. 中华肺部疾病杂志(电子版), 2023, 16(05): 706-708.

Lili Zhang, Min Yang, Yani Shi. Clinical analysis of MR-proADM as a prognostic biomarker for community-acquired pneumonia[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(05): 706-708.

目的

分析肾上腺髓质素前体中肽段(mid-regional proAdrenomedullin, MR-proADM)作为社区获得性肺炎(CAP)预后生物标志物的潜在效用。

方法

2018年10月至2020年4月,我院收治的CAP患者63例作为对象,纳入58例健康者作为对照组。使用时间分辨荧光免疫分析法测定血浆MR-proADM含量。通过受试者工作特征(ROC)曲线来评估其识别能力。采用Spearman秩相关检验和Logistic回归检验评估MR-proADM水平与疾病严重程度和预后之间的相关性。

结果

CAP患者血浆MR-proADM水平为0.92(0.48,1.67)nmol/L,高于对照组[0.35(0.16,0.63)nmol/L](P<0.001)。血浆MR-proADM对CAP有识别价值,ROC曲线下面积为0.744(95%CI:0.674~0.813)。血浆MR-proADM水平与肺炎严重程度指数(r=0.379,P<0.001)、CURB-65(r=0.230,P=0.007)、住院时间(r=0.546,P<0.001)之间存在正相关。基于多变量Logistic回归分析,血浆MR-proADM浓度对院内死亡、入住ICU和住院时间>10 d具有预测能力(P<0.05)。

结论

MR-proADM可以用于临床初步筛查CAP的一个潜在的预后生物标志物。

表1 多因素Logistic回归分析MR-proADM、PSI、CURB65、CRP对CAP院内死亡、入住ICU和住院时间>10 d预后结局
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