回顾性分析成人肺朗格汉斯细胞组织细胞增生症(pulmonary Langerhans cell histiocytosis, PLCH)患者临床资料，提高临床对PLCH的认识。

收集我院诊治的1例PLCH患者临床资料，查阅并复习相关的文献资料。

患者以张口受限、胸闷、胸痛起病，胸部CT提示肺部团片影，经验性抗感染治疗后无好转，院外多次行经皮肺穿刺活检未明确诊断，就诊于我院后经验性抗感染的同时再次行经皮肺穿刺活检，最终明确诊断为PLCH，经化疗治疗后症状缓解，病灶吸收。

成人PLCH是罕见的以朗格汉斯细胞弥漫性增殖浸润为主的组织内异常组织细胞增生性疾病，临床症状及体征差异较大，容易误诊，必要时需行多次组织活检，免疫组织化学试验对明确诊断至关重要。成人PLCH的治疗应根据疾病程度严格制定个体化治疗方案，同时应定期随访，动态评估预后，及时根据病情调整治疗方案。

To improve the clinical understanding of Pulmonary Langerhans cell histiocytosis, The clinical data of one adult patient diagnosed and treated in our hospital were retrospectively collected and analyzed.

The clinical data of the patient with Pulmonary Langerhans cell histiocytosis were retrospectively collected and the related literature was reviewed.

The empiric antiinfective therapy did not improve symptoms in the patient with restricted mouth opening, chest tightness, chest pain, and chest CT suggesting lung masses. Percutaneous lung puncture biopsy was performed several times outside the hospital, but the diagnosis was not clear. After being admitted to our hospital, the patient underwent a percutaneous lung puncture biopsy while empiric anti-infection was performed again, and the diagnosis was finally confirmed as Pulmonary Langerhans cell histiocytosis.

The PLCH of adult is a rare abnormal histiocytic proliferative disease in tissues mainly characterized by diffuse proliferation and infiltration of Langerhans cells. Its clinical symptoms and signs vary greatly, and this disease is easy to be misdiagnosed. Multiple tissue biopsies are required when necessary, and immunohistochemical tests are crucial for definite diagnosis. The treatment of adult PLCH should be strictly individualized according to the severity of the disease. Meanwhile, regular follow-up should be conducted to dynamically evaluate the prognosis and timely adjust the treatment plan according to the condition.