分析慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)认知衰弱危险因素，探讨预后及意义。

选择2022年1月至2023年7月我院收治的59例COPD患者为对象，其中无认知衰弱18例为对照组，认知衰弱41例为观察组。采用一般资料调查表、衰弱表型量表(frailty phenotype scale)、医院焦虑抑郁量表(hospital anxiety and depression scale)、主观认知下降问卷(subjective cognitive decline)、简易精神状态评估量表(mini-mental state examination scale)搜集资料，收集出院后6个月生存状况。使用卡方检验、秩和检验、t检验、Logistic回归分析、Cox生存分析等对数据进行分析。

观察组平均年龄(61.25±9.86)岁，吸烟12例(66.67%)较对照组(56.74±8.53)岁，吸烟14例(34.15%)差异有统计学意义(P<0.05)。两组教育程度、共病指数、生活能力差异有统计学意义(P＝0.004，0.000，0.016)。Logistic回归分析显示，年龄(OR＝0.005，95%CI：0～0.108)、教育程度(OR＝0.004，95%CI：0～0.102)和生活能力(OR＝0.093，95%CI：0.011～0.784)是COPD患者认知衰弱的影响因素(P<0.05)。随访6个月生存者51例(86.44%)，死亡者8例(13.56%)。Cox生存分析显示，COPD患者认知衰弱预后不良是认知正常的2.48倍(95%CI：1.548～4.395，P＝0.001)。

高龄、教育程度低、生活能力低下是COPD患者认知衰弱的危险因素。尽早干预，延缓认知衰弱进展，以期降低COPD认知衰弱患者病死率具有临床意义。

To analyze the risk factors of cognitive frailty in patinets with chronic obstructive pulmonary disease (COPD), and to investigate the prognosis and significance of these.

A total of 59 COPD patients admitted to our hospital from January 2022 to July 2023 were selected as subjects, including 18 patients without cognitive frailty as control group and 41 patients with cognitive frailty as observation group. Data were collected by general data questionnaire, frailty phenotype scale, hospital anxiety and depression scale, subjective cognitive decline questionnaire and mini-mental state examination scale, the survival status of 6 months after discharge was collected. Chi-square test, rank sum test, t test, Logistic regression analysis and Cox survival analysis were used to analyze the data.

The average age of the observation group was (61.25±9.86) years old and 12 smokers (66.67%) compared with the control group (56.74±8.53) years old and 14 smokers (34.15%) (P<0.05). There were significant differences in education level, comorbidity index and living ability between the two groups (P=0.004, 0.000, 0.016). Logistic regression analysis showed that age (OR=0.005, 95%CI: 0-0.108), education level (OR=0.004, 95%CI: 0-0.102) and life ability (OR=0.093, 95%CI: 0.011-0.784) was the influence factor of COPD cognitive frailty (P<0.05). After 6 months of follow-up, there were 51 survivors (86.44%) and 8 deaths (13.56%). Cox survival analysis showed that poor prognosis in COPD was 2.48 times greater than that in normal COPD (95%CI: 1.548-4.395, P=0.001).

Old age, low education level and low life ability are risk factors of COPD cognitive frailty. Early intervention can delay the progress of cognitive frailty and reduce the mortality rate.