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中华肺部疾病杂志(电子版) ›› 2025, Vol. 18 ›› Issue (02) : 334 -337. doi: 10.3877/cma.j.issn.1674-6902.2025.02.025

综述

外泌体环状RNA 与肺癌关系
徐康乔1, 张国清1, 严智亮2, 姜涌斌3,()   
  1. 1. 201803 上海,上海市第一人民医院嘉定医院/上海市嘉定区江桥医院呼吸内科
    2. 200040 上海,复旦大学附属华东医院消化内科
    3. 214065 无锡,上海市保健医疗中心(华东疗养院)健康管理科
  • 收稿日期:2024-12-27 出版日期:2025-04-25
  • 通信作者: 姜涌斌
  • 基金资助:
    上海市嘉定区卫生健康委员会科研课题计划(2023-KY-10)

Relationship between exosomal circular RNA and lung cancer

Kangqiao Xu, Guoqing Zhang, Zhiliang Yan, Yongbin Jiang()   

  • Received:2024-12-27 Published:2025-04-25
  • Corresponding author: Yongbin Jiang
引用本文:

徐康乔, 张国清, 严智亮, 姜涌斌. 外泌体环状RNA 与肺癌关系[J/OL]. 中华肺部疾病杂志(电子版), 2025, 18(02): 334-337.

Kangqiao Xu, Guoqing Zhang, Zhiliang Yan, Yongbin Jiang. Relationship between exosomal circular RNA and lung cancer[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2025, 18(02): 334-337.

肺癌是全球发病率和病死率最高的恶性肿瘤之一,其治疗面临低生存率和耐药性等挑战。 外泌体环状RNA 是一种存在于外泌体中,通过外泌体递送并发挥生物学作用的环状RNA。 近年来,大量研究发现,外泌体环状RNA 与肺癌的发生发展密切相关。 这类分子通过吸附微小RNA 发挥“海绵”作用,从而调控下游目标基因表达,参与肺癌细胞的增殖、凋亡、转移与耐药等过程。 外泌体环状RNA 不仅可作为肺癌的诊断标志物,有助于肺癌的早诊早治,并且其可作为有前景的治疗工具,通过靶向调控相关通路,并利用其生物相容性开发新型疗法,如环状RNA 疫苗或靶向递送系统,为肺癌的精确诊断和治疗提供新的思路与方向。

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