To explore clinical characteristics of patients with infectious caused by carbapenem-resistant Klebsiella pneumonia (CRKP) in an intensive care unit (ICU).

The clinical features, laboratory manifestations, the diagnosis and treatment of patients with CRKP infection from October 2015 to December 2015 in ICU of Xinqiao Hospital, Third Military Medical University were analyzed retrospectively.

The incidence of CRKP in ICU is 27.42%, and most of the CRKP patients were old male (average age was 64.14±14.45, male accounted for 78.57%). Fever ( 85.71% in CRKP group versus 51.35% in non-CRKP group, 9.09% in non-infection group, χ²=14.484, P=0.001), white blood cell count (15.70±6.92 versus 10.09±4.33, 9.41±4.48×10⁹/L, χ²=9.980, P=0.007), C reactive protein (142.00(50.50, 240.00) versus 71.10(27.00, 107.50), 14.10(5.00, 53.30) mg/L, χ²=9.387, P=0.009) and procalcitonin (3.50(1.07, 27.05) versus 0.71(0.20, 3.14), 0.20(0.20, 0.30)μg/L, χ²=16.236, P<0.001) increased were the main performance. The CRKP mortality rate (35.71% versus 45.95%, 36.36%, χ²=0.607, P=0.738) didn′t increase due to the tigecycline combined with carbapenem treatment, but the hospitalization time (33.00(18.75, 44.50) versus 7.00(4.00, 11.50), 9.00(4.00, 13.00) days, χ²=15.398, P<0.001) and hospitalization costs (23.92(10.14, 36.08) versus 4.41(2.64, 11.22), 2.80(1.94, 3.19) million yuan, χ²=21.370, P<0.001) extended.

CRKP epidemic is prone in ICU. Reduction in the non-standard use of broad-spectrum antibiotics and unnecessary invasive operation, timely adjustment of anti infection scheme, is an important measure to control the epidemic of CRPK and reduce the clinical burden.