Effects of mindfulness-based intervention model on the quality of life and psychological status of lung cancer patients during chemotherapy

doi:10.3877/cma.j.issn.1674-6902.2017.01.011

Abstract

Abstract:

Objective

To explore the effects of mindfulness-based intervention model on the quality of life and psychological status of lung cancer patients during chemotherapy.

Methods

A total of 76 patients with lung cancer during chemotherapy were randomly divided into control group and observation group, the control group were given routine nursing. In addition, patients in observation group received mindfulness-based intervention. The EORTC QLQ-30 and SAS scales, SDS scales were used to evaluate the quality of life of the patients before and after the 8-week intervention.

Results

Before intervention, there was no significant difference in quality of life (QOL)between the two groups. After 8 weeks of intervention, the overall health score of observation group was 59.6±5.0, the control group was 59.6±5.0. In fatigue, pain, nausea and vomiting, the score of observation was 43.2±2.7, 26.2±4.3, 30.5±5.6, and the control group was 57.8±4.2, 47.8±3.9, 51.4±5.6, the difference was statistically significant, the QOL of the observation group was better than control group, P<0.05. Two groups of patients with anxiety, depression scores were reduced. The SAS score of observation group was 38.64±5.02, the control group was 44.06±5.24. And the SDS score of observation group was 41.26±5.2, the control group was 46.89±5.34, the psychologic status of observation group was better than the control group, P<0.05.

Conclusions

Mindfulness-based intervention can effectively improve the psychological status and quality of life of lung cancer patients during chemotherapy.

Key words: Bronchiogenic cancer, Chemotherapy, Intervention, Mindfulness level, Quality of life

Xiu Xu, Dan Feng, Qingzhu Jia, Daoxiao Wang, Jun Zhou, Ping Chen. Effects of mindfulness-based intervention model on the quality of life and psychological status of lung cancer patients during chemotherapy[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2017, 10(01): 50-54.

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References 28

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临床资料	观察组	对照组	t/χ²值	P值
性别	?	?	?	?
男	32(53.33)	34(58.62)	0.1544	0.6944
女	28(46.67)	24(41.38)	?	?
年龄(±s，岁)	58.95±6.46	59.41±5.76	0.1025	0.8977
肿瘤分期(例)	?	?	?	?
ⅡB	35(58.33)	32(55.17)	0.0258	0.8724
Ⅳ	25(41.67)	26(44.83)	?	?
病理分型	?	?	?	?
小细胞肺癌	22(36.67)	20(34.48)	0.0031	0.9558
非小细胞肺癌	38(63.33)	38(65.52)	?	?
文化程度	?	?	(0)	(1.000)
中上(大学/高中)	52(86.67)	50(86.21)	?	?
初等(小学/文盲)	8(13.33)	8(13.79)	?	?
肿瘤并发症	2	3	0.214	0.644

临床资料	观察组	对照组	t/χ²值	P值
性别	?	?	?	?
男	32(53.33)	34(58.62)	0.1544	0.6944
女	28(46.67)	24(41.38)	?	?
年龄(±s，岁)	58.95±6.46	59.41±5.76	0.1025	0.8977
肿瘤分期(例)	?	?	?	?
ⅡB	35(58.33)	32(55.17)	0.0258	0.8724
Ⅳ	25(41.67)	26(44.83)	?	?
病理分型	?	?	?	?
小细胞肺癌	22(36.67)	20(34.48)	0.0031	0.9558
非小细胞肺癌	38(63.33)	38(65.52)	?	?
文化程度	?	?	(0)	(1.000)
中上(大学/高中)	52(86.67)	50(86.21)	?	?
初等(小学/文盲)	8(13.33)	8(13.79)	?	?
肿瘤并发症	2	3	0.214	0.644

变量及分组		观察组(n＝60)			对照组(n＝58)			t值	P值
变量及分组		干预前	干预后	差值1	干预前	干预后	差值2	t值	P值
总体健康		66.8±5.0	59.6±3.4	7.2±1.0	67.2±4.9	29.8±3.4	36.8±2.0	102.540	<0.01
功能		?	?	?	?	?	?	?	?
?	躯体	68.8±2.8	59.3±3.5	10.8±1.8	67.6±2.6	30.2±2.7	34.2±2.46	59.111	<0.01
?	角色	64.8±3.2	58.6±2.4	12.2±1.4	63.8±2.8	23.6±1.8	40.2±1.8	94.503	<0.01
?	情绪	57.4±3.8	49.8±2.4	8.4±1.2	54.6±4.3	32.6±2.9	22.1±2.6	36.950	<0.01
?	认知	66.2±2.5	61.6±2.8	6.6±1.8	67.1±2.8	42.6±2.8	25.8±3.2	40.343	<0.01
?	社会	74.2±5.4	67.8±2.2	7.0±1.0	75.2±6.4	33.6±2.8	34.5±3.2	63.447	<0.01
症状		?	?	?	?	?	?	?	?
?	疲劳	34.2±2.7	43.2±2.8	9.6±2.0	33.6±1.8	57.8±4.2	24.6±3.2	30.644	<0.01
?	疼痛	20.8±6.5	26.2±4.3	6.8±1.2	21.5±5.8	47.8±3.9	27.8±2.5	58.476	<0.01
?	恶心呕吐	20.8±4.2	30.5±5.6	9.0±1.4	21.2±3.2	51.4±5.6	31.2±3.6	44.423	<0.01
特异性		?	?	?	?	?	?	?	?
?	气促	26.8±4.9	36.2±5.6	10.2±1.6	28.4±4.2	38.6±4.3	10.5±1.7	0.987	0.325
?	失眠	29.2±3.2	36.2±5.8	8.6±1.2	28.4±3.6	56.2±5.6	27.6±1.6	73.137	<0.01
?	食欲	30.2±2.6	48.6±5.2	8.0±1.5	31.2±3.2	59.5±5.2	29.6±2.8	52.475	<0.01
?	便秘	26.3±3.2	32.6±3.8	8.2±1.6	25.2±5.6	60.2±2.8	33.2±1.8	79.805	<0.01
?	腹泻	34.2±4.8	40.6±7.2	7.1±2.6	32.8±4.2	39.8±6.2	8.1±1.8	2.421	0.017
?	经济状况	51.4±3.5	56.8±6.8	6.4±0.8	50.6±3.9	60.6±6.8	10.2±3.5	8.193	<0.01

变量及分组		观察组(n＝60)			对照组(n＝58)			t值	P值
变量及分组		干预前	干预后	差值1	干预前	干预后	差值2	t值	P值
总体健康		66.8±5.0	59.6±3.4	7.2±1.0	67.2±4.9	29.8±3.4	36.8±2.0	102.540	<0.01
功能		?	?	?	?	?	?	?	?
?	躯体	68.8±2.8	59.3±3.5	10.8±1.8	67.6±2.6	30.2±2.7	34.2±2.46	59.111	<0.01
?	角色	64.8±3.2	58.6±2.4	12.2±1.4	63.8±2.8	23.6±1.8	40.2±1.8	94.503	<0.01
?	情绪	57.4±3.8	49.8±2.4	8.4±1.2	54.6±4.3	32.6±2.9	22.1±2.6	36.950	<0.01
?	认知	66.2±2.5	61.6±2.8	6.6±1.8	67.1±2.8	42.6±2.8	25.8±3.2	40.343	<0.01
?	社会	74.2±5.4	67.8±2.2	7.0±1.0	75.2±6.4	33.6±2.8	34.5±3.2	63.447	<0.01
症状		?	?	?	?	?	?	?	?
?	疲劳	34.2±2.7	43.2±2.8	9.6±2.0	33.6±1.8	57.8±4.2	24.6±3.2	30.644	<0.01
?	疼痛	20.8±6.5	26.2±4.3	6.8±1.2	21.5±5.8	47.8±3.9	27.8±2.5	58.476	<0.01
?	恶心呕吐	20.8±4.2	30.5±5.6	9.0±1.4	21.2±3.2	51.4±5.6	31.2±3.6	44.423	<0.01
特异性		?	?	?	?	?	?	?	?
?	气促	26.8±4.9	36.2±5.6	10.2±1.6	28.4±4.2	38.6±4.3	10.5±1.7	0.987	0.325
?	失眠	29.2±3.2	36.2±5.8	8.6±1.2	28.4±3.6	56.2±5.6	27.6±1.6	73.137	<0.01
?	食欲	30.2±2.6	48.6±5.2	8.0±1.5	31.2±3.2	59.5±5.2	29.6±2.8	52.475	<0.01
?	便秘	26.3±3.2	32.6±3.8	8.2±1.6	25.2±5.6	60.2±2.8	33.2±1.8	79.805	<0.01
?	腹泻	34.2±4.8	40.6±7.2	7.1±2.6	32.8±4.2	39.8±6.2	8.1±1.8	2.421	0.017
?	经济状况	51.4±3.5	56.8±6.8	6.4±0.8	50.6±3.9	60.6±6.8	10.2±3.5	8.193	<0.01

组　别		例数	SAS	SDS
观察组		60	?	?
?	干预前	30	52.82±5.16	53.76±6.42
?	干预后	30	38.64±5.02^ab	41.26±5.2^ab
对照组		58	?	?
?	干预前	30	53.11±5.26	53.84±6.56
?	干预后	28	44.06±5.24^a	46.89±5.34^a

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