To study radical cure effect of introducing different doses of midazolam anesthesia on postoperative analgesia in patients with thoracoscope lung carcinoma.

Between August 2014 and July 2015, choosing 82 patients with thoracoscope lung cancer in our hospital, according to the draw method, they were divided into observation group (41 cases) and control group (41 patients). Observation group were treated with 0.1 mg/kg of midazolam anesthesia induction, control group were given the dose of 0.05 mg/kg of midazolam for induction of anesthesia. Two groups of patients with preoperative and 48 h postoperative inflammatory factor levels, blood oxygen saturation, mean arterial pressure, heart rate changes were compared, the two groups of patients with surgery situation were analyzed.

postoperative 48 h, observation group with IL - 6, IL 8, IL-1β, TNF alpha inflammation factor index were lower than the control group[(58.43±3.21)μg/L, (2.03±0.25)μg/L, (2.97 ±0.43)μg/L, (5.32±0.76)μg/L vs. (96.43±4.53)μg/L, (3.22±0.32)μg/L, (3.76±0.43)μg/L, (7.63±0.98)μg/ L](P<0.05). After 48 h surgery, observation group of blood oxygen saturation, mean arterial pressure, heart rate were significantly lower than the control group[(93.78±1.07)%, (93.21±3.45)mmHg, (87.54±2.34)time/min vs. (97.12±1.02)%, (96.43±4.02)mmHg, (91.04±2.88) time/min] (P<0.05). Two groups of patients with blood loss, operative time, anesthesia time had no significant difference (P>0.05), but the observation group of patients with open time, extubation time was significantly shorter than the control group (P<0.05), postoperative pain score, the total dosage of propofol, rui total fentanyl was significantly less than the control group (P<0.05).

In patients with thoracoscope lung cancer treated using dose of 0.1 mg/kg of midazolam anesthesia induction, relative to the dose of 0.05 mg/kg of midazolam, can effectively inhibit the inflammatory response, maintain anesthesia narcotic drug usage, to ensure more smoothly, the perioperative period in patients with effective alleviate postoperative pain patients, belongs to the ideal dosage regimen.