Application of different doses of Dexmedetomidine in chronic obstructive pulmonary disease patients with mechanical ventilation and the influence on pulmonary function

doi:10.3877/cma.j.issn.1674-6902.2017.04.016

Abstract

Abstract:

Objective

To research the application of different doses of Dexmedetomidine in chronic obstructive pulmonary disease (COPD) patients with mechanical ventilation and the influence on pulmonary function.

Methods

All 102 cases of COPD patients from November 2014 to November 2016 in Shenzhen People′s Hospital, it was divided into control group and experimental group according to the draw method, each group of 51 cases, control group intravenous infusion of 1.0 μg/kg·h of dexmedetomidine treatment, the experimental group intravenous infusion of 0.6 μg/kg·h of dexmedetomidine treatment, two groups of hemodynamics, pulmonary function and inflammatory factor and safety before and after the medication were observed.

Results

Before treatment, the hemodynamics, pulmonary function and inflammatory factor of two groups was no difference (P>0.05). After medication, hemodynamic and inflammatory factor of experimental group was better than that of control group (P<0.05). The pulmonary effective compliance, arterial blood oxygen partial pressure of experimental group were higher than the control group (56.54±7.06 vs. 52.96±6.42) ml/H₂O, (98.34±12.16 vs. 93.12±11.88)mmHg, the respiratory index, alveolar-arterial oxygen partial pressure of experimental were lower than the control group (0.23±0.02 vs. 0.25±0.03), (21.20±2.65 vs. 23.32±2.92)mmHg (P<0.05). The adverse reaction rate of experimental group was lower than the control group (P<0.05).

Conclusion

Low-dose Dexmedetomidine has little influcence on hemodynamics in patients with COPD mechanical ventilation, can protect lung function, reduce inflammation.

Key words: Chronic obstructive pulmonary disease, Dexmedetomidine, Mechanical ventilation, Lung function

Yaowen Luo, Wei Shi. Application of different doses of Dexmedetomidine in chronic obstructive pulmonary disease patients with mechanical ventilation and the influence on pulmonary function[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2017, 10(04): 441-444.

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References 26

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组　别	例数	舒张压(mmHg)		收缩压(mmHg)		心率(次/min)
组　别	例数	用药前	用药后	用药前	用药后	用药前	用药后
对照组	51	126.78±15.75	139.74±16.62	76.85±9.50	85.44±10.20	83.24±10.42	92.36±9.87
实验组	51	125.94±15.60	132.60±16.11	76.20±9.21	80.32±9.91	83.75±10.99	88.07±10.75
t值	?	0.270	2.110	0.350	2.571	0.240	2.099
P值	?	0.787	0.037	0.726	0.011	0.810	0.038

组　别	例数	舒张压(mmHg)		收缩压(mmHg)		心率(次/min)
组　别	例数	用药前	用药后	用药前	用药后	用药前	用药后
对照组	51	126.78±15.75	139.74±16.62	76.85±9.50	85.44±10.20	83.24±10.42	92.36±9.87
实验组	51	125.94±15.60	132.60±16.11	76.20±9.21	80.32±9.91	83.75±10.99	88.07±10.75
t值	?	0.270	2.110	0.350	2.571	0.240	2.099
P值	?	0.787	0.037	0.726	0.011	0.810	0.038

组　别	例数	肺有效顺应性(ml/H₂O)		呼吸指数		肺泡-动脉氧分压差(mmHg)		动脉血氧分压(mmHg)
组　别	例数	用药前	用药后	用药前	用药后	用药前	用药后	用药前	用药后
对照组	51	50.35±6.23	52.96±6.42	0.28±0.04	0.25±0.03	25.60±3.20	23.32±2.92	73.71±9.21	93.12±11.88
实验组	51	50.97±6.35	56.54±7.06	0.28±0.05	0.23±0.02	25.89±3.12	21.20±2.65	73.22±9.87	98.34±12.16
t值	?	0.497	2.679	<0.001	3.961	0.463	3.839	0.259	2.192
P值	?	0.618	0.008	1.000	<0.001	0.644	<0.001	0.796	0.028

组　别	例数	肺有效顺应性(ml/H₂O)		呼吸指数		肺泡-动脉氧分压差(mmHg)		动脉血氧分压(mmHg)
组　别	例数	用药前	用药后	用药前	用药后	用药前	用药后	用药前	用药后
对照组	51	50.35±6.23	52.96±6.42	0.28±0.04	0.25±0.03	25.60±3.20	23.32±2.92	73.71±9.21	93.12±11.88
实验组	51	50.97±6.35	56.54±7.06	0.28±0.05	0.23±0.02	25.89±3.12	21.20±2.65	73.22±9.87	98.34±12.16
t值	?	0.497	2.679	<0.001	3.961	0.463	3.839	0.259	2.192
P值	?	0.618	0.008	1.000	<0.001	0.644	<0.001	0.796	0.028

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