Thymosin α1 was able to relieve the inhibitory effect of EGFR-TKI on peripheral blood T lymphocyte subsets of the patients with non-small cell lung cancer

doi:10.3877/cma.j.issn.1674-6902.2019.01.011

Abstract

Abstract:

Objective

Comparative analysis of peripheral blood T lymphocyte subsets before patients treated with epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI) and patients after receiving EGFR-TKI monotherapy or combined with Thymosin α1 therapy.

Methods

The data of peripheral blood T lymphocyte subsets of patients receiving EGFR-TKI and EGFR-TKI combined with Thymosin α1 was collected from May 2008 to August 2018.

Results

The number of Peripheral blood CD4⁺ , CD8⁺ and CD3⁺ T lymphocyte of patients were decreased after EGFR-TKI treatment alone(P<0.05), the number of those T lymphocytes shown no difference before EGFR-TKI monotherapy and after receiving EGFR-TKI plus Thymosin α1 therapy (P>0.05).

Conclusions

EGFR-TKI could decrease the peripheral blood T lymphocyte subsets of patients treated with EGFR-TKI, thymosin α1 was able to reverse the inhibitory effect of EGFR-TKI on peripheral blood T lymphocyte subsets of patients to some extent.

Key words: Epidermal growth factor receptor tyrosine kinase inhibitor, Thymosin α1, T lymphocyte subsets

Guangkuo Zhu, Linpeng Zheng, Qiao Yang, Zhoufei Wang, Zihan Xu, Jianguo Sun, Zhengtang Chen. Thymosin α1 was able to relieve the inhibitory effect of EGFR-TKI on peripheral blood T lymphocyte subsets of the patients with non-small cell lung cancer[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2019, 12(01): 59-62.

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References 22

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