To investigate the protective effect of flurbiprofen axetil combined with protective mechanical ventilation on lung function and the levels of inflammatory factors, levels of beta-EP and PGE in patients undergoing thoracic surgery.

90 patients in July 2015 to July 2017 year in in our hospital for the treatment of open radical resection of thoracic esophageal cancer, according to randomly divided into A, B, C three groups, A group were treated with protective mechanical ventilation treatment, B group were treated with flurbiprofen axetil combined with conventional mechanical ventilation therapy, group C used flurbiprofen axetil combined protective mechanical ventilation. The operation, PaO₂, OI, lung function abnormalities, inflammatory factors, and levels of beta-EP and PGE were compared between the three groups.

There was no significant difference in the time of mechanical ventilation, the time of single lung ventilation, the amount of blood loss, the volume of fluid infusion and the operation time between the three groups, and the difference was statistically significant (P>0.05). The level of PaO₂ increased in three groups after 1 and 4 hours, and the level of PaO₂ decreased after 2, 3 and 5 hours; the level of PaO₂/FiO₂ increased after 1 and 4 hours, and decreased after 2, 3 and 5 hours. After 2 hours treatment, the levels of PaO₂ and PaO₂/FiO₂ in the three groups were significantly different, with statistical significance (P<0.05). Three groups of patients did not appear before the treatment of abnormal pulmonary function, intraoperative varying degrees of abnormal pulmonary function, postoperative only A, B, two groups of patients with abnormal pulmonary function. The incidence of postoperative pulmonary dysfunction in the three groups was significantly different, with statistical significance (P<0.05). After 4 hours treatment, the concentrations of TNF-α, IL-6 and IL-8 increased in the three groups. After treatment for fifth hours, the concentrations of TNF-α, IL-6 and IL-8 decreased significantly. After fourth hours treatment, the concentrations of TNF-α, IL-6 and IL-8 in the three groups were significantly different, with statistical significance (P<0.05). The levels of beta-EP and PGE in the three groups increased significantly during the first three hours, but decreased after fifth hours. After 5 hours treatment, the levels of beta-EP and PGE in the C group were higher than those in the B group, and the level of B group was higher than that of the A group, and the difference was statistically significant (P<0.05).

Conclusion flurbiprofen axetil combined with protective mechanical ventilation has better lung protective effect and can inhibit the production of inflammatory factors in patients undergoing thoracic surgery. It is worthy of clinical use.