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Chinese Journal of Lung Diseases(Electronic Edition) ›› 2019, Vol. 12 ›› Issue (04): 420-425. doi: 10.3877/cma.j.issn.1674-6902.2019.04.004

• Original Article • Previous Articles     Next Articles

Meta-analysis on relationship between HHIP rs13118928 single nucleotide polymorphism and susceptibility to chronic obstructive pulmonary disease

Tianyong Wu1,(), Hongbin Chen2, Dan Cheng2   

  1. 1. Department of Respiratory Medicine, People′s Hospital of Bole, Bole 833400, Xinjiang Uygur Autonomous Region, China
    2. Department of Respiratory Medicine, People′s Hospital of Wuhan University, Wuhan 430060, China
  • Received:2019-01-15 Online:2019-08-20 Published:2021-07-19
  • Contact: Tianyong Wu

Abstract:

Objective

To explore whether the HHIP rs13118928 single nucleotide polymorphism (SNP) is associated with the susceptibility to chronic obstructive pulmonary disease (COPD).

Methods

Based on our inclusion criteria, a systematic search of the relevant studies from the construction of the database until January 5, 2018 was conducted using the PubMed, EMBASE, Web of Science, CNKI and Wanfang databases. Meta-analysis was performed with RevMan 5.3 software. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated under allelic and genotypic comparisons.

Results

Seven reports containing 5 157 COPD patients and 9768 controls met the inclusion criteria. The results suggested a significant relationship between HHIP rs13118928 SNP and COPD susceptibility (A vs. G, OR=1.14, 95%CI, 1.08-1.20, P<0.001; AA vs. GG, OR=1.36, 95%CI, 1.20-1.55, P<0.001; AG vs. GG; OR=1.27, 95%CI, 1.03-1.58, P=0.030; AA+ AG vs. GG, OR=1.31, 95%CI, 1.10-1.57, P=0.003; AA vs. AG+ GG, OR=1.12, 95%CI, 1.04-1.21, P=0.002). Subgroup analysis by ethnicity indicated that there existed a significant relationship between rs13118928 SNP and the occurrence of COPD under A vs. G and AA vs. GG models in both Asian and Caucasian population.

Conclusion

The present meta-analysis suggests that HHIP rs13118928 SNP is significantly related with COPD susceptibility.

Key words: HHIP gene, Single nucleotide polymorphism, Chronic obstructive pulmonary disease, Meta-analysis

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