Expression and clinical significance of EFhd1 in patients with non-small cell lung cancer

doi:10.3877/cma.j.issn.1674-6902.2019.05.008

Abstract

Abstract:

Objective

To investigate the expression of EFhd1 and its potential value as a prognostic indicator of survival in the patients with primary non-small cell lung cancer (NSCLC).

Methods

A total of 178 NSCLC tissue specimens and 51 paracancerous tissue specimens were collected from 178 NSCLC surgical patients from January 2004 to April 2011 in the Cardiothoracic Surgery Department of the Affiliated Hospital of Nantong University. The clinical data and follow-up data were collected, too. Immunohistochemical analysis with tissue microarray was used to characterize the expression of EFhd1 in the NSCLC tissues. The relationship between the EFhd1 expression and the clinical characteristics and prognosis was determined by statistical analysis.

Results

The level of EFhd1 expression was higher in the NSCLC tissues than in the paracancerous tissues (P<0. 05). The EFhd1 expression in the NSCLC tissues was related to the T staging (P<0.05). Univariate analysis revealed that TNM stage, T stage and N stage were associated with the prognosis of NSCLC (P<0.01). Kaplan Meier survival and Cox regression analyses revealed that the higher level of EFhd1 expression (P=0.037) and later stage grouping by TNM (P=0.001) were independent factors predicting poor prognosis for the patients with NSCLC.

Conclusion

The level of EFhd1 expression in the NSCLC tissues is significantly higher than that in the adjacent tissues. Our finding provides the first evidence that the higher level of EFhd1 expression is associated with the poor prognosis of the patients with NSCLC.

Key words: EFhd1, Non-small cell lung cancer, Immunohistochemistry, Clinicopathologic parameters, Prognosis

Liqin Xu, Mengyuan Lyu, Jian Feng. Expression and clinical significance of EFhd1 in patients with non-small cell lung cancer[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2019, 12(05): 573-578.

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URL: https://zhfbjbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-6902.2019.05.008

https://zhfbjbzz.cma-cmc.com.cn/EN/Y2019/V12/I05/573

Figures/Tables 4

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临床资料		EFhd1表达		χ²值	P值
临床资料		低表达	高表达	χ²值	P值
性别
	女	25(24.8)	16(20.8)	0.389	0.533
	男	76(75.2)	61(79.2)
年龄
	≤60岁	37(36.6)	21(27.3)	1.743	0.187
	>60岁	64(63.4)	56(72.7)
组织学类型
	鳞癌	58(57.4)	38(49.4)	1.910	0.385
	腺癌	27(26.7)	28(36.4)
	其他	16(15.8)	11(14.3)
肿瘤直径
	≤3 cm	51(50.5)	31(40.3)	1.452	0.228
	>3 cm	50(49.5)	46(59.7)
T分期
	T1	31(30.7)	28(36.4)	7.345	0.025
	T2	53(52.5)	46(59.7)
	T3-T4	17(16.9)	3(3.9)
N分期
	N0	45(44.6)	43(55.8)	2.327	0.312
	N1	31(20.7)	20(26.0)
	N2	25(24.8)	14(18.2)
M分期
	M0	100(99.0)	77(100)	0.767	0.381
	M1	1(1.0)	0
分化程度
	未知	23(22.8)	20(26.0)	0.493	0.920
	低	17(16.8)	13(16.9)
	中	57(56.4)	40(51.9)
	高	4(4.0)	4(5.2)
TNM分期
	Ⅰ期	32(31.7)	34(44.2)	4.252	0.236
	Ⅱ期	37(36.6)	27(35.1)
	Ⅲ期	31(30.7)	16(20.8)
	Ⅳ期	1(1.0)	0

临床资料		EFhd1表达		χ²值	P值
临床资料		低表达	高表达	χ²值	P值
性别
	女	25(24.8)	16(20.8)	0.389	0.533
	男	76(75.2)	61(79.2)
年龄
	≤60岁	37(36.6)	21(27.3)	1.743	0.187
	>60岁	64(63.4)	56(72.7)
组织学类型
	鳞癌	58(57.4)	38(49.4)	1.910	0.385
	腺癌	27(26.7)	28(36.4)
	其他	16(15.8)	11(14.3)
肿瘤直径
	≤3 cm	51(50.5)	31(40.3)	1.452	0.228
	>3 cm	50(49.5)	46(59.7)
T分期
	T1	31(30.7)	28(36.4)	7.345	0.025
	T2	53(52.5)	46(59.7)
	T3-T4	17(16.9)	3(3.9)
N分期
	N0	45(44.6)	43(55.8)	2.327	0.312
	N1	31(20.7)	20(26.0)
	N2	25(24.8)	14(18.2)
M分期
	M0	100(99.0)	77(100)	0.767	0.381
	M1	1(1.0)	0
分化程度
	未知	23(22.8)	20(26.0)	0.493	0.920
	低	17(16.8)	13(16.9)
	中	57(56.4)	40(51.9)
	高	4(4.0)	4(5.2)
TNM分期
	Ⅰ期	32(31.7)	34(44.2)	4.252	0.236
	Ⅱ期	37(36.6)	27(35.1)
	Ⅲ期	31(30.7)	16(20.8)
	Ⅳ期	1(1.0)	0

临床资料		单因素分析			多因素分析
临床资料		HR	P值	95%CI	HR	P值	95%CI
性别		0.986	0.942	0.668～1.454
	女 vs.男
年龄		1.096	0.616	0.766～1.567
	≤60 vs. >60
T分期		1.465	0.006	1.113～1.928
	T1 vs. T2 vs.T3-T4
N分期		1.689	0.001	1.387～2.055
	N0 vs. N1 vs. N2
M分期		0.879	0.898	0.123～6.290
	M0 vs. M1
临床分期		1.725	0.001	1.420～2.097	1.824	0.001	1.359～2.449
	Ⅰ期 vs. Ⅱ期 vs. Ⅲ-Ⅳ期
组织类型		0.954	0.667	0.770 ～1.182
	鳞癌 vs.腺癌 vs.其它
分化程度		0.917	0.410	0.746～1.127
	低 vs.中 vs.高vs.未知
肿瘤直径		1.213	0.322	0.822～1.790
	≤3 cm vs. >3 cm
EFhd1表达程度		1.328	0.147	0.950～1.948	1.679	0.037	1.031～2.734
	低表达 vs.高表达

临床资料		单因素分析			多因素分析
临床资料		HR	P值	95%CI	HR	P值	95%CI
性别		0.986	0.942	0.668～1.454
	女 vs.男
年龄		1.096	0.616	0.766～1.567
	≤60 vs. >60
T分期		1.465	0.006	1.113～1.928
	T1 vs. T2 vs.T3-T4
N分期		1.689	0.001	1.387～2.055
	N0 vs. N1 vs. N2
M分期		0.879	0.898	0.123～6.290
	M0 vs. M1
临床分期		1.725	0.001	1.420～2.097	1.824	0.001	1.359～2.449
	Ⅰ期 vs. Ⅱ期 vs. Ⅲ-Ⅳ期
组织类型		0.954	0.667	0.770 ～1.182
	鳞癌 vs.腺癌 vs.其它
分化程度		0.917	0.410	0.746～1.127
	低 vs.中 vs.高vs.未知
肿瘤直径		1.213	0.322	0.822～1.790
	≤3 cm vs. >3 cm
EFhd1表达程度		1.328	0.147	0.950～1.948	1.679	0.037	1.031～2.734
	低表达 vs.高表达

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