To explore the effects of folic acid combined with mecobalamin on the oxidative stress, inflammatory factors and pulmonary functions in the patients with stable chronic obstructive pulmonary disease (COPD) complicated with hyperhomocysteinemia.

A total of 89 patients with stable COPD complicated with hyperhomocysteinemia diagnosed in our hospital from July 2016 to June 2018 were selected, and they were randomly divided into a control and an observation group. The control group was treated with conventional treatments, and the observation group was given folic acid combined with mecobalamin on the basis of the conventional treatments. All the patients were treated for 8 weeks. The levels of homocysteine (Hcy), oxidative stress markers [superoxide dismutase (SOD) and malondialdehyde (MDA)], inflammatory factors [C-reactive protein (CRP) and interleukin 6 (IL-6)] and pulmonary function indexes [the forced expiratory volume in one second as percentage of predicted volume (FEV₁%pred), the forced expiratory volume in one second/the forced vital capacity (FEV₁/FVC)] of the patients in the two groups before and after treatment were compared.

The general situation and levels of Hcy, SOD, MDA, CRP, IL-6, FEV₁%pred and FEV₁/FVC before treatment showed no significant difference between the two groups (P>0.05). There was no significant difference in the levels of Hcy, SOD, MDA, CRP, IL-6, FEV₁%pred and FEV₁/FVC before and after treatment in the control group (P>0.05), while they were ameliorated in the observation group (P<0.05). The levels of Hcy, MDA, CRP and IL-6 were reduced (P<0.05) and the levels of SOD, FEV₁%pred and FEV₁/FVC were increased (P<0.05) after treatment in the observation group compared with the control group.

Folic acid combined with mecobalamin can effectively reduce the levels of Hcy and improve the status of oxidative stress, inflammation and pulmonary functions in the patients with COPD complicated with hyperhomocysteinemia.