Correlation between expression levels of insulin-like growth factor-1 receptor and Cezanne-1 and epidermal growth factor receptor gene mutations in lung adenocarcinoma tissues

doi:10.3877/cma.j.issn.1674-6902.2020.03.007

Abstract

Abstract:

Objective

To analyze the correlation between the expression levels of insulin-like growth factor-1 receptor (IGF1R) and Cezanne-1 and the gene mutations of epidermal growth factor receptor (EGFR) in lung adenocarcinoma tissues.

Methods

Clear lung adenocarcinoma tissues and para-carcinoma tissues obtained from the 56 patients with lung adenocarcinoma who were pathologically diagnosed in our hospital from March 2017 to April 2019 were included in the case group, and lesion tissues from the 51 patients with benign pulmonary lesions who underwent surgical treatment during the same period were included in the control group. The expression levels of IGF1R and Cezanne-1 and EGFR gene mutations of all the included tissue samples were examined, and the detection rates of IGF1R and Cezanne-1 positive expression and EGFR gene mutations were compared between the two groups. The clinical features, the positive detection rates of IGF1R and Cezanne-1 expression of the lung adenocarcinoma patients with different EGFR gene mutations were compared. The correlation between the expression levels of IGF1R and Cezanne-1 and EGFR gene mutations was analyzed, too.

Results

The positive detection rates of EGFR gene mutations and the expression levels of IGF1R and Cezanne-1 in the lung adenocarcinoma tissues were higher than those of the para-carcinoma tissues and the benign pulmonary lesions (P<0.05). There was no statistical significant difference in the clinical features between the lung adenocarcinoma patients with EGFR gene mutations and the lung adenocarcinoma patients without gene mutations (P>0.05). However, compared with the lung adenocarcinoma tissues without EGFR gene mutations, the positive detection rates of IGF1R and Cezanne-1 expression in the tissues with gene mutations were higher (P<0.05). The IGF1R and Cezanne-1 expression had positive correlations with EGFR gene mutations (r>0, P<0.05).

Conclusion

The IGF1R and Cezanne-1 are over-expressed in the lung adenocarcinoma tissues, and the EGFR gene mutation rate is higher than that of other normal tissues. Moreover, the over-expression of IGF1R and Cezanne-1 is significantly related to EGFR gene mutations.

Key words: Lung adenocarcinoma, IGF1R, Cezanne-1, EGFR gene mutation, Correlation, Predictive value

Yibulayin Waresijiang·, Zhenhua Wu, Wei Sun, Abulaiti Abulimiti·. Correlation between expression levels of insulin-like growth factor-1 receptor and Cezanne-1 and epidermal growth factor receptor gene mutations in lung adenocarcinoma tissues[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2020, 13(03): 324-328.

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References 30

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组　别		例数	组织样本	EGFR基因突变阳性例数(例)	阳性率(%)
研究组		56	肺腺癌组织	32	57.14
			癌旁组织	6	10.71^ab
对照组		51	肺部良性组织	1	1.96
	χ²值		-	-	52.835
	P值		-	-	<0.001

组　别		例数	组织样本	EGFR基因突变阳性例数(例)	阳性率(%)
研究组		56	肺腺癌组织	32	57.14
			癌旁组织	6	10.71^ab
对照组		51	肺部良性组织	1	1.96
	χ²值		-	-	52.835
	P值		-	-	<0.001

肺腺癌EGFR基因突变情况		例数	性别(例)		年龄(岁)	吸烟史(例)		TNM分期(例)
肺腺癌EGFR基因突变情况		例数	男性	女性	年龄(岁)	有	无	Ⅰ期	Ⅱ期	Ⅲ期	Ⅳ期
突变患者		32	21	11	52.47±7.11	20	12	2	6	17	7
未突变患者		24	15	9	49.09±11.02	11	13	1	7	12	4
统计值		-	0.058^a		1.393^b	1.542^a		0.650^c
	P值	-	0.809^a		0.169^b	0.214^a		0.516^c

肺腺癌EGFR基因突变情况		例数	性别(例)		年龄(岁)	吸烟史(例)		TNM分期(例)
肺腺癌EGFR基因突变情况		例数	男性	女性	年龄(岁)	有	无	Ⅰ期	Ⅱ期	Ⅲ期	Ⅳ期
突变患者		32	21	11	52.47±7.11	20	12	2	6	17	7
未突变患者		24	15	9	49.09±11.02	11	13	1	7	12	4
统计值		-	0.058^a		1.393^b	1.542^a		0.650^c
	P值	-	0.809^a		0.169^b	0.214^a		0.516^c

组　别		例数	组织样本	IGF1R		Cezanne-1
组　别		例数	组织样本	例数	阳性率(%)	例数	阳性率(%)
研究组		56	肺腺癌组织	36	64.29^ab	38	67.86^ab
			癌旁组织	8	14.29	10	17.86
对照组		51	肺部良性组织	3	5.88	4	7.84
	χ²值		-	53.167		51.997
	P值		-	<0.001		<0.001

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