Abstract:
Objective To analyze the correlation between levels of serum Cystatin C (CysC), vascular endothelial growth factor (VEGF) and activin A (ACTA) and disease severity in elderly patients with chronic obstructive pulmonary disease (COPD) complicated with respiratory failure (RF).
Methods A total of 106 elderly patients with COPD and RF who were treated in West China Hospital, Sichuan University were selected as RF group. The patients were divided into mild group (36 cases), moderate group (41 cases) and severe group (29 cases) according to the partial pressure of blood oxygen (PaO2). Another 47 patients with simple COPD admitted to the hospital during the same time period were selected as non-RF group. The levels of serum CysC, VEGF, and ACTA and the percentage of forced expiratory volume in one second and predicted value (FEV1) and percentage of forced expiratory volume in one second and forced vital capacity (FEV1/FVC) were compared in each group, and the correlation between levels of serum CysC, VEGF and ACTA and FEV1% and FEV1/FVC were analyzed.
Results The levels of serum CysC and ACTA in RF group were higher than those in non-RF group (P<0.05) while the VEGF level, FEV1% and FEV1/FVC were lower than those in non-RF group (P<0.05). The more severe the elderly COPD patients with RF, the higher the serum CysC and ACTA levels and the lower the VEGF level, FEV1% and FEV1/FVC. And there were significant differences between mild group, moderate group and severe group (P<0.05). Pearson correlation test results showed that the serum CysC in elderly patients with COPD and RF was significantly negatively correlated with FEV1%, and FEV1/FVC (r=-0.530, P<0.01, r=-0.594, P<0.01). VEGF was significantly positively correlated with FEV1%, and FEV1/FVC (r=0.571, P<0.01, r=0.668, P<0.01). ACTA was significantly negatively correlated with FEV1% and FEV1/FVC (r=-0.604, P<0.01, r=-0.557, P<0.01).
Conclusion Serum CysC, VEGF, and ACTA levels in elderly patients with COPD and RF are closely related to the disease severity, and they are helpful for timely disease assessment in patients.
Key words:
Chronic obstructive pulmonary disease,
Respiratory failure,
Cystatin protease inhibitor C,
Vascular endothelial growth factor,
Activin A,
Correlation,
Elderly
Jing Zeng, Yong Jiang, Lin Zhu. Correlation between levels of serum CysC, VEGF, and ACTA and disease severity in elderly patients with COPD and respiratory failure[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2020, 13(06): 719-723.