To analyze the pathogenicity and drug resistance changes of common pathogens of infant community acquired pneumonia in Shiyan area.

1 282 children with cap admitted to many hospitals in Shiyan district from February 2018 to February 2019 were selected to collect the deep sputum samples of all children, identify the bacterial species in the sputum, carry out the drug sensitivity test with MIC method, and detect the resistance of the bacteria detected to the commonly used antibiotics.

in 282 children with cap, 684 (53.35%) were positive in physical examination, of which 146 (21.35%) were positive in Streptococcus pneumoniae, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterobacter aerogenes and Enterobacter cloacae (P<0.05). The detection rates of Mycoplasma pneumoniae and Chlamydia pneumoniae were 6.16% (79/1 282) and 11.39% (146/1 282), respectively. The detection rates of Mycoplasma pneumoniae and Chlamydia pneumoniae in children aged 12-36 months were 13.71% (51/372) and 25.81% (96/372), respectively, which were significantly higher than 3.08% (28/910) and 5.49% (50/910) of children with age ≤12 months (all P<0.05). Among Gram-positive bacteria, the resistance rate of Streptococcus pneumoniae to erythromycin, tetracycline and clindamycin was more than 80%, that of Staphylococcus aureus to penicillin, erythromycin, clindamycin and ampicillin was more than 50%, and that of Streptococcus pneumoniae and Staphylococcus aureus to vancomycin and linezolid. Among Gram-negative bacteria, Escherichia coli and Klebsiella pneumoniae were resistant to cefazolin, ceftazidime, cefepime, ceftriaxone, ampicillin, and aztreonam more than 70%; Haemophilus influenzae was resistant to ampicillin the highest; Pseudomonas aeruginosa was resistant to ceftriaxone and cefotetan 100%; Gram-positive bacteria were resistant to piperacillin and amikacin the lowest.

Streptococcus pneumoniae is the common pathogen of infant community acquired pneumonia in Shiyan area, which is resistant to erythromycin, tetracycline and clindamycin. Sensitive antibiotics should be used to improve the treatment efficiency.