Explore the diagnostic value and related influencing factors of ultrasound-guided biopsy of peripheral lung lesions, and summarize the methods and techniques to improve the diagnosis rate.

Analysis 311 patients were hospitalized in the First Affiliated Hospital of Guangzhou Medical University due to peripheral lung lesions and underwent ultrasound-guided lung biopsy with puncture pathological results from January 2018 to January 2019.Through single factor analysis and multivariate logistic regression analysis, whether the gender, age, lesion location, lesion size, diameter of the contact surface between the lesion and the pleura, whether there is necrosis in the lesion, and the number of needle insertions are factors affecting the diagnosis rate of ultrasound-guided biopsy of peripheral lung lesions.

The overall diagnosis rate of 311 cases of ultrasound-guided biopsy of peripheral lung lesions was 86.2% (268/311), the total complication rate was 10.3% (32/311), and the incidence rate of pneumothorax was 2.3% (7/311) ), the incidence of hemoptysis was 6.1% (19/311), the incidence of pleural effusion was 1.0% (3/311), and the incidence of pleural reaction was 1.0% (3/311). Univariate analysis found that: the size of the lesion, the diameter of the contact surface between the lesion and the pleura, and the presence or absence of necrosis in the lesion affected the diagnosis rate of ultrasound-guided peripheral lung lesion biopsy (P<0.05); but the patient′s gender, age, lesion location and The number of needle insertions was not related to the diagnosis rate (P>0.05). Multivariate logistic regression analysis found that the size of the lesion is not an independent influencing factor for the diagnosis rate of biopsy of peripheral lung lesions guided by ultrasound (P>0.05); and the diameter of the contact surface between the lesion and the pleura is a protective factor for the diagnosis rate (P<0.05, β=1.059, OR=2.882). The presence or absence of necrosis in the lesion is a risk factor for the diagnosis rate (P<0.05, β=-0.895, OR=0.409).

The diameter of the contact surface between the lesion and the pleura, and whether there is necrosis in the lesion are important factors that affect the diagnosis rate of biopsy of peripheral lung lesions guided by ultrasound. Therefore, mastering the puncture skills of the lesion with a small contact surface between the lesion and the pleura and avoiding the necrotic area of the lesion can better improve the diagnosis rate of ultrasound-guided puncture biopsy of peripheral lung lesions.