Significance of neutrophil extracellular net level combined with lung function in predicting acute attack of bronchial asthma

doi:10.3877/cma.j.issn.1674-6902.2021.05.012

Abstract

Hui Cai, Hang Hu, Ya Cao. Significance of neutrophil extracellular net level combined with lung function in predicting acute attack of bronchial asthma[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2021, 14(05): 599-601.

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References 28

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组　别	例数	cf-DNA/NETs(μg/L)	PEF(%)	FEV₁(%)
A组	56	456.58±46.26^a	80.15±7.68^a	80.32±7.62^a
B组	33	273.44±28.32	86.24±8.79	85.39±8.65
F值	-	1 183.096	47.111	50.087
P值	-	0.000	0.000	0.000

组　别	例数	cf-DNA/NETs(μg/L)	PEF(%)	FEV₁(%)
A组	56	456.58±46.26^a	80.15±7.68^a	80.32±7.62^a
B组	33	273.44±28.32	86.24±8.79	85.39±8.65
F值	-	1 183.096	47.111	50.087
P值	-	0.000	0.000	0.000

因　素	β	SE	Wald	P值	OR	95%CI
有创通气治疗	1.123	0.357	9.895	<0.001	3.074	1.265~7.471
血清cf-DNA/NETs水平	1.006	0.348	8.357	<0.001	2.735	1.125~6.646
PEF	1.176	0.321	13.422	<0.001	3.241	1.334~7.878
FEV₁	1.020	0.345	8.741	<0.001	2.773	1.141~6.740

因　素	β	SE	Wald	P值	OR	95%CI
有创通气治疗	1.123	0.357	9.895	<0.001	3.074	1.265~7.471
血清cf-DNA/NETs水平	1.006	0.348	8.357	<0.001	2.735	1.125~6.646
PEF	1.176	0.321	13.422	<0.001	3.241	1.334~7.878
FEV₁	1.020	0.345	8.741	<0.001	2.773	1.141~6.740

指　标	最佳截断点	灵敏度(%)	特异度(%)	AUC	95%CI	约登指数	P值
血清cf-DNA/NETs水平	485.21 μg/L	78.46	79.23	0.762	0.668~0.857	0.680	0.048
PEF	72.14(%)	80.00	80.77	0.777	0.682~0.872	0.880	0.048
FEV₁	71.69(%)	77.69	80.00	0.756	0.661~0.850	0.700	0.048
联合	-	87.69	73.85	0.915	0.851~0.980	0.740	0.033

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