TLR4/NF­&#x03BA;B pathway and cytokine level in COPD complicated with pulmonary infection

doi:10.3877/cma.j.issn.1674-6902.2022.02.020

Abstract

Jiwen Xu, Jingya Xu, Bin Zong. TLR4/NFκB pathway and cytokine level in COPD complicated with pulmonary infection[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2022, 15(02): 221-223.

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References 26

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组　别		例数	IL-4(ng/L)	TNF-α(μg/L)	IFN-α(ng/L)	TLR4mRNA	NF-κBmRNA
观察组		68	85.69±8.58^a	48.25±5.64^a	26.24±5.32^a	3.86±1.01^a	1.96±0.59^a
对照组		29	64.58±6.47	40.47±4.32	7.86±1.85	1.32±0.36	0.85±0.19
	t值	-	11.874	6.637	18.098	13.157	9.889
	P值	-	0.000	0.000	0.000	0.000	0.000

组　别		例数	IL-4(ng/L)	TNF-α(μg/L)	IFN-α(ng/L)	TLR4mRNA	NF-κBmRNA
观察组		68	85.69±8.58^a	48.25±5.64^a	26.24±5.32^a	3.86±1.01^a	1.96±0.59^a
对照组		29	64.58±6.47	40.47±4.32	7.86±1.85	1.32±0.36	0.85±0.19
	t值	-	11.874	6.637	18.098	13.157	9.889
	P值	-	0.000	0.000	0.000	0.000	0.000

临床资料		存活者(n＝56)	死亡者(n＝12)	χ²/t值	P值
性别	男	27(48.21)	8(66.67)	1.347	0.246
	女	29(51.79)	4(33.33)
APACHEⅡ评分		24.12±5.21	28.39±6.32	2.481	0.016
WBC(×10⁹/L)		21.07±3.63	21.24±3.56	0.148	0.883
IL-4(ng/L)		50.28±5.41	50.17±5.32	0.064	0.949
TNF-α(μg/L)		30.16±3.74	46.24±4.12	13.282	0.000
IFN-α(ng/L)		4.36±0.89	4.32±0.85	0.142	0.887
TLR4mRNA		0.28±0.04	2.85±0.63	31.100	0.000
NF-κBmRNA		0.37±0.06	1.96±0.52	22.798	0.000
机械通气	是	22(39.29)	4(33.33)	0.148	0.756
	否	34(60.71)	8(66.67)
吸烟史	是	30(53.57)	7(58.33)	0.090	0.764
	否	26(46.43)	5(41.67)
糖皮质激素	是	38(67.86)	9(75.00)	0.236	0.627
	否	18(32.14)	3(25.00)
广谱抗生素	是	40(71.43)	10(83.33)	0.720	0.396
	否	16(28.57)	2(16.67)
感染原菌类型	G⁺	30(53.57)	6(50.00)	11.717	0.007
	G^-	24(42.86)	2(16.67)
	真菌	2(3.57)	4(33.33)

临床资料		存活者(n＝56)	死亡者(n＝12)	χ²/t值	P值
性别	男	27(48.21)	8(66.67)	1.347	0.246
	女	29(51.79)	4(33.33)
APACHEⅡ评分		24.12±5.21	28.39±6.32	2.481	0.016
WBC(×10⁹/L)		21.07±3.63	21.24±3.56	0.148	0.883
IL-4(ng/L)		50.28±5.41	50.17±5.32	0.064	0.949
TNF-α(μg/L)		30.16±3.74	46.24±4.12	13.282	0.000
IFN-α(ng/L)		4.36±0.89	4.32±0.85	0.142	0.887
TLR4mRNA		0.28±0.04	2.85±0.63	31.100	0.000
NF-κBmRNA		0.37±0.06	1.96±0.52	22.798	0.000
机械通气	是	22(39.29)	4(33.33)	0.148	0.756
	否	34(60.71)	8(66.67)
吸烟史	是	30(53.57)	7(58.33)	0.090	0.764
	否	26(46.43)	5(41.67)
糖皮质激素	是	38(67.86)	9(75.00)	0.236	0.627
	否	18(32.14)	3(25.00)
广谱抗生素	是	40(71.43)	10(83.33)	0.720	0.396
	否	16(28.57)	2(16.67)
感染原菌类型	G⁺	30(53.57)	6(50.00)	11.717	0.007
	G^-	24(42.86)	2(16.67)
	真菌	2(3.57)	4(33.33)

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