To explore the distribution of pathogenic bacteria in the bloodstream of 305 patients with acquired pneumonia and analysis of their drug resistance.

A total of 305 hospital-acquired pneumonia patients in our hospital from March 2019 to July 2020 were selected as the research subjects. The age, gender, length of stay, combined underlying diseases, proton pump inhibitor treatment and tracheal intubation cases, and primary disease were selected. Information on the site of infection, blood culture, and drug susceptibility test results were collected.

Among the 305 patients with acquired pneumonia, 174 had complicated bloodstream infections, accounting for 57.05%. A total of 186 pathogenic bacteria were isolated, of which 137 were G^-, accounting for 73.66%. Klebsiella pneumoniae was the most among G^-. It accounted for 17.20%, followed by Acinetobacter baumannii and Pseudomonas aeruginosa, accounting for 15.59% and 12.90% respectively. 46 strains of G⁺ , accounting for 24.73%, the most G⁺ Staphylococcus aureus, accounting for 10.22%. 3 strains of fungi, accounting for 1.61%. The drug susceptibility results of this study showed that Klebsiella pneumoniae had high resistance to ceftriaxone and ampicillin, but low resistance to aztreonam and tobramycin. Acinetobacter baumannii has high resistance to ceftriaxone and nitrofurantoin, but low resistance to aztreonam and gentamicin. Pseudomonas aeruginosa has high resistance to ampicillin and nitrofurantoin, but low resistance to amikacin, compound trimethoprim and aztreonam. Staphylococcus aureus has high resistance to penicillin G and erythromycin, but low resistance to vancomycin and teicoplanin. Streptococcus pneumoniae has high resistance to penicillin G, erythromycin, and gentamicin, but low resistance to vancomycin and teicoplanin.

The distribution of pathogenic bacteria in the bloodstream of patients with acquired pneumonia is mainly G^-. Among them, Klebsiella pneumoniae and Acinetobacter baumannii infection are more common, and they are highly resistant to ampicillin, nitrofurantoin and cephalosporins. Staphylococcus aureus is more common in G⁺ infections, and it is highly resistant to azithromycin, erythromycin and penicillin drugs.