Primary mucinous adenocarcinoma of the lung: three cases report and literature review

doi:10.3877/cma.j.issn.1674-6902.2023.02.008

Abstract

Abstract:

Objective

To investigate the clinical manifestations, imaging features and pathological characteristics of primary pulmonary mucinous adenocarcinoma (PPMA) and improve the understanding of the disease.

Methods

Through the clinical diagnosis and treatment of 3 cases of primary mucinous lung adenocarcinoma from June 2022 to October 2022 was analyzed. All of them were female, aged 73 to 85 old. Combined with literature analysis and literature review, to strengthen clinicians′understanding of the clinical manifestations, imaging characteristics and pathological characteristics of this disease, improve the level of diagnosis and treatment.

Results

The primary mucinous adenocarcinoma of the lung was mainly invasive mucinous adenocarcinoma. The clinical manifestations were not specific, and it was easy to be misdiagnosed. The diagnosis mainly depended on pathology, and the treatment was mainly early operation.

Conclusion

PPMA is a special subtype of lung adenocarcinoma with low incidence and poor prognosis. The lack of specificity in clinical diagnosis mainly depends on biopsy.

Key words: Primary mucinous lung adenocarcinoma, Invasive mucinous adenocarcinoma, Literature review

Nini Wang, Rongrong Chen, Qing Zhang, Chengshi Zhang, Donghui Cui, Jian Wu, Han Lei, Yunfeng Zhao. Primary mucinous adenocarcinoma of the lung: three cases report and literature review[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(02): 190-194.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhfbjbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-6902.2023.02.008

https://zhfbjbzz.cma-cmc.com.cn/EN/Y2023/V16/I02/190

Figures/Tables 3

References 30

1	孙瑞琼，王　爽. 原发性肺黏液腺癌多层螺旋CT影像表现[J/CD]. 中华肺部疾病杂志(电子版), 2022, 15(2): 260-262.
2	Travis WD, Brambilla E, Burke AP, et al. Introduction to the 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart[J]. J Thorac Oncol, 2015, 10(9): 1240-1242.
3	Türüt H, Demirag F, Gulhan E, et al. Primary pulmonary mucinous adenocarcinoma in a 15-year-old boy[J]. Eur J Cardiothorac Surg, 2006, 29(5): 851-853.
4	Babiy Y, Sychova T, Dykan I. Radiological aspects of the new "International multidisciplinary classification of lung adenocarcinoma" ：Methodological bases and own experience[J]. Radiation Diagnostics Radiation Therapy, 2019(4): 55-71.
5	Choi Y, Kim KH, Jeong BH, et al. Clinicoradiopathological features and prognosis according to genomic alterations in patients with resected lung adenocarcinoma[J]. J Thorac Dis, 2020, 12(10): 5357-5368.
6	Blackstone N, El-Aini T. Medical image of the month: Mucinous adenocarcinoma of the lung mimicking pneumonia[J]. Southwest J Pulmonary and Cri Care, 2021, 22(1)：8-10.
7	Shim HS, Kenudson M, Zheng Z, et al. Unique genetic and survival characteristics of invasive mucinous adenocarcinoma of the lung[J]. J Thorac Oncol, 2015, 10(8): 1156-1162.
8	Geles A, Gruber-Moesenbacher U, Quehenberger F, et al. Pulmonary mucinous adenocarcinomas: architectural patterns in correlation with genetic changes, prognosis and survival[J]. Virchows Arch, 2015, 467(6): 675-686.
9	Austin JH, Garg K, Aberle D, et al. Radiologic implications of the 2011 classification of adenocarcinoma of the lung[J]. Radiology, 2013, 266(1): 62-71.
10	Shenoy V, Buckley M, Hosseini H, et al. S1710 signet ring cell mucinous adenocarcinoma of the colon manifesting as intermittent hiccups[J]. Official J American College of Gastroenterology ACG, 2020, 115(1): 882-883.
11	Sun F, Wang P, Zheng Y, et al. Diagnosis, clinicopathological characteristics and prognosis of pulmonary mucinous adenocarcinoma[J]. Oncol Lett, 2018, 15(1): 489-494.
12	周　蕾. 79例肺原发性粘液腺癌的临床分析[D]. 大连医科大学，2017: 1-5.
13	魏朋华. 原发性肺粘液腺癌的临床病理及分子特征的回顾性分析[D]. 山东大学，2020: 3-8.
14	Moon SW, Choi SY, Moon MH. Effect of invasive mucinous adenocarcinoma on lung cancer-specific survival after surgical resection: a population-based study[J]. J Thorac Dis, 2018, 10(6): 3595-3608.
15	Boland JM, Maleszewski JJ, Wampfler JA, et al. Pulmonary invasive mucinous adenocarcinoma and mixed invasive mucinous/nonmucinous adenocarcinoma-a clinicopathological and molecular genetic study with survival analysis[J]. Hum Pathol, 2018, 71: 8-19.
16	Cha YJ, Kim HR, Lee HJ, et al. Clinical course of stage Ⅳ invasive mucinous adenocarcinoma of the lung[J]. Lung Cancer, 2016, 102: 82-88.
17	Kim DH, Bae SY, Na KJ, et al. Radiological and clinical features of screening-detected pulmonary invasive mucinous adenocarcinoma[J]. Interact Cardiovasc Thorac Surg, 2022, 34(2): 229-235.
18	Blackstone N, El-Aini T. Medical image of the month: Mucinous adenocarcinoma of the lung mimicking pneumonia[J]. Southwest J Pulmonary and Critical Care, 2021, 22(1): 8-10.
19	Perre SV, Duron L, Milon A, et al. Radiomic analysis of HTR-DCE MR sequences improves diagnostic performance compared to BI-RADS analysis of breast MR lesions[J]. Eur Radiol, 2021, 31(7): 4848-4859.
20	Nakaoku T, Tsuta K, Ichikawa H, et al. Druggable oncogene fusions in invasive mucinous lung adenocarcinoma[J]. Clin Cancer Res, 2014, 20(12): 3087-3093.
21	Shin DH, Lee D, Hong DW, et al. Oncogenic function and clinical implications of SLC3A2-NRG1 fusion in invasive mucinous adenocarcinoma of the lung[J]. Oncotarget, 2016, 7(43): 69450-69465.
22	Laskin J, Liu SV, Tolba K, et al. NRG1 fusion－driven tumors: biology, detection, and the therapeutic role of afatinib and other ErbB-targeting agents[J]. Ann Oncol, 2020, 31(12): 1693-1703.
23	Guo M, Tomoshige K, Meister M, et al. Gene signature driving invasive mucinous adenocarcinoma of the lung[J]. EMBO Mol Med, 2017, 9(4): 462-481.
24	Duruisseaux M, Antoine M, Rabbe N, et al. Lepidic predominant adenocarcinoma and invasive mucinous adenocarcinoma of the lung exhibit specific mucin expression in relation with oncogenic drivers[J]. Lung Cancer, 2017, 109: 92-100.
25	Milewski D, Balli D, Ustiyan V, et al. FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas[J]. PLoS Genet, 2017, 13(12): e1007097.
26	Truini A, Santos Pereira P, Cavazza A, et al. Classification of different patterns of pulmonary adenocarcinomas[J]. Expert Rev Respir Med, 2015, 9(5): 571-586.
27	Lantuejoul S, Rouquette I, Brambilla E, et al. [New WHO classification of lung adenocarcinoma and preneoplasia][J]. Ann Pathol, 2016, 36(1): 5-14.
28	Lee HJ, Lee CH, Jeong YJ, et al. IASLC/ATS/ERS International Multidisciplinary Classification of Lung Adenocarcinoma: novel concepts and radiologic implications[J]. J Thorac Imaging, 2012, 27(6): 340-353.
29	Kuhn E, Morbini P, Cancellieri A, et al. Adenocarcinoma classification：patterns and prognosis[J]. Pathologica, 2018, 110(1): 5-11.
30	Travis WD, Brambilla E, Noguchi M, et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma[J]. J Thorac Oncol, 2011, 6(2): 244-285.

[1]	Zhiwen Li, Weiming Liao. Research progress in prevention of malrotational alignment of femoral and tibial prostheses during total knee arthroplasty [J]. Chinese Journal of Joint Surgery(Electronic Edition), 2018, 12(03): 396-400.
[2]	Yiming Lai, Lujie Li, Kun Xia, Guohui Huang, Shengmeng Peng, Wanhua Wu, Huiyang Fan, Zhen Lei, Zhenghui Guo. Primary renal synovial sarcoma: a case report and literature review [J]. Chinese Journal of Endourology(Electronic Edition), 2020, 14(06): 473-476.
[3]	Chunyan Li, Jiancheng Xu, Yue Zhang, Jing Xu, Mingdong Hu. Pulmonary sarcomatoid carcinoma: a case report and review of the literature [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(02): 195-199.
[4]	Yanwu Ou, Hongli Li, Yu Liu, Yan Wang, Guansong Wang, Songlin Chen, Xin Yang, Qinqin Chen, Wei Yao. Pleura rhabdomyosarcoma: a case report and review of the literature [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2017, 10(01): 55-58.
[5]	Xin Lu, Qinfu Feng. Colonic metastasis of lung squamous cell carcinoma: A case report and literature review [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2019, 08(01): 76-79.
[6]	Xue Wen, Hong Sun, Hong Wang, Miao Liu, Xu Ning. Research progress of PTHrP analogue abaloparide in osteoporosis [J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2021, 07(02): 117-121.
[7]	Ruyang Chen, Zhanyu Yang, Xiaodi Ma, Yanhua Huang, Min Zhou. Research progress of whole body vibration therapy in rehabilitation [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2020, 10(06): 374-377.
[8]	Xuefen Chen, Jingmin Deng. Literature review of 179 cases of primary pulmonary lymphoepithelioma-like carcinoma in the last 30 years [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(05): 551-556.
[9]	Fei Kong, Fabing Tang, Qiong Wei, Shanlin Fan, Wenzhen Yuan. Surgical treamtent of giant gastrointestinal mesenchymal tumor after neoadjuvant therapy: a case report and review of the literature [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(03): 360-363.
[10]	Kun Pang, Zhenduo Shi, Lin Hao, Bo Chen, Conghui Han. Progress in application of confocal laser endomicroscopy in diagnosis of urothelial tumors [J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(04): 296-301.
[11]	Fang Tian, Ruiming Wu, Ting Zeng, Jiru Liu, Juan Li. Research progress on the application of cognitive function assessment tools in patients with stroke [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2021, 15(03): 191-195.

Please choose a citation manager

Content to export