Abstract:

Objective

To investigate the curative effect of Qingfei Huatan Zhuyu Decoction，a traditional Chinese medicine，on acute exacerbation of chronic obstructive pulmonary disease（AECOPD）patients and its influence on CXC chemokine ligand 8 （CXCL8），CXC chemokine receptors 1 （CXCR1） and CXC chemokine receptors 2 （CXCR2）.

Methods

A total of 86 patients with COPD admitted to our hospital from January 2020 to December 2023 were selected and divided into control group 45 cases and observation group 41 cases according to the treatment method.The control group was inhaled indacaterol maleate and glycopyrronium bromide inhalation powder，once a day.On the basis of the control group，the observation group took oral Qingfei Huatan Zhuyu Decoction，a traditional Chinese medicine，one dose per day，divided into 2 times in the morning and evening，and both groups were treated for 12 weeks.The clinical efficacy，lung function，inflammatory factor levels，CXCL8-CXCR1/CXCR2 pathway protein levels，modified medical research council （mMRC） and COPD assessment test （CAT） scores，and the incidence of side effects was contrasted between the two groups.

Results

The total effective rate of the observation group was 36 cases（87.80%），which was higher than the 31 cases （68.89%） in the control group （P ＜0.05）.No notable disparity emerged in the frequency of adverse events between the two groups （P＞0.05）.After treatment，the observation group forced expiratory volume in one second （FEV₁） （1.66±0.34） L，maximal voluntary ventilation （MVV） （56.35±7.86） L/min，peak expiratory flow （PEF） （4.02±0.78） L/s，partial pressure of oxygen （PaO₂） （84.32±17.62） mmHg，arterial oxygen saturation （SaO₂） （95.76±18.75） % were higher than control group （1.50±0.31）L，（52.86±6.89）L/min，（3.63±0.71）L/s，（78.43±15.37）mmHg，（91.89±16.34）%.The observation group partial pressure of carbon dioxide （PaCO₂） （42.39±6.85） mmHg，surfactant associated protein D （SP-D） （88.42±13.75） ng/ml，von willebrand factor （vWF） （9.79±1.35）pg/ml，matrix metalloproteinase 9 （MMP-9） （208.25±56.27） ng/ml，CXCL8 （272.49±45.24）ng/L，CXCR1（269.72±67.83） ng/L，CXCR2 （257.64±71.78） ng/L，mMRC （1.71±0.26） scores，CAT （19.46±3.15）scores were lower than control group（46.45±8.65）mmHg，（92.95±15.62）ng/ml，（10.16±0.65）pg/ml，（217.38±73.25）ng/ml，（283.65±57.21）ng/L，（288.56±85.26）ng/L，（278.36±82.91）ng/L，（1.88±0.32）scores，（21.37±3.23）scores.

Conclusions

The traditional Chinese medicine Qingfei Huatan Zhuyu Decoction has proven effective in treating patients with COPD by improving pulmonary function，reducing inflammatory responses，and inhibiting the expression of CXCL8，CXCR1，and CXCR2，demonstrating clinical significance.

Key words: Acute exacerbation of chronic obstructive pulmonary disease, Qingfei Huatan Zhuyu Decoction, CXC chemokine ligand 8, CXC chemokine receptors 1, CXC chemokine receptors 2, Inflammation