To analyze the correlation between peripheral blood heart-type fatty acid binding protein (H-FABP) and myocardial injury and prognosis in patients with severe pneumonia.

Sixty-four patients with severe pneumonia treated in our hospital from April 2020 to April 2024 were selected as the subjects. They were grouped according to the prognosis. 21 cases died as the observation group and 43 cases survived as the control group. The H-FABP and troponin Ⅰ in the peripheral blood of the patients were detected, and the correlation between H-FABP and troponin Ⅰ in the peripheral blood was analyzed by Spearman correlation. The general data of the two groups of patients were compared, and Logisic regression was used to analyze the influencing factors of the prognosis of severe pneumonia. The receiver operating characteristic(ROC) curve was applied to analyze the prediction of peripheral blood H-FABP level for the prognosis of patients with severe pneumonia.

The H-FABP in the peripheral blood of 64 patients was (6.88±1.41)ng/ml; Troponin Ⅰ was 0.28 (0.14, 0.45) μg/L. The Spearman results showed that H-FABP in peripheral blood was positively correlated with troponin Ⅰ (r=0.647, P<0.05); Age of the observation group, Acute Physiology and Chronic Health Evaluation Ⅱ score is Acute Physiology and Chronic Health Evaluation Ⅱ(APACHEⅡ) (19.33±1.80)points, peripheral blood H-FABP (8.03±0.74)ng/ml, troponin Ⅰ 0.47(0.44, 0.53)were higher than the age, APACHEⅡ (17.77±2.29) points, peripheral blood H-FABP (6.33±1.32)ng/ml, and troponin Ⅰ 0.21 (0.10, 0.28) μg/L of the control group (P<0.05). The results of multivariate Logistic regression showed that age (OR=1.780, 95%CI: 1.166~2.717), APACHE Ⅱ(OR=1.779, 95%CI: 1.104~2.866), and peripheral blood H-FABP (OR=5.476, 95%CI: 1.769~16.948) were risk factors for the prognosis of patients with severe pneumonia (P<0.05); ROC analysis showed that age, APACHE Ⅱ, and the area under the curve of peripheral blood H-FABP predicted the prognosis of patients with severe pneumonia. The area under the curve (AUC) values were 0.847, 0.712, and 0.873 respectively (P<0.05).

Age, APACHE Ⅱ, and peripheral blood H-FABP level are the influencing factors for the prognosis of patients with severe pneumonia. There is a correlation between peripheral blood H-FABP level and myocardial injury, which can predict the prognosis of patients with severe pneumonia.