Sample analysis NOD heat receptor protein structure domain related protein 3 (NLRP3) signaling pathways and related cell factors to predict the value of the death of elderly patients with severe pneumonia was.

The clinical data of 100 elderly patients with severe pneumonia treated in our hospital from June 2021 to June 2024 were prospectively analyzed, and the patients were divided into survival group and death group according to whether they survived for 28 days. The baseline data, NLRP3 signaling pathway and related cytokine levels of the two groups were compared.Multiariable Logistic regression analysis of the risk factors of death of elderly patients with severe pneumonia was taken ROC analysis was used to analyze the value of pneumonia severity index (PSI) score, NLRP3 signaling pathway and related cytokines in predicting the death of elderly patients with severe pneumonia.

37 of 100 elderly patients with severe pneumonia died, the mortality rate was 37%. 63 patients were discharged successfully after treatment, and the survival rate was 63%. The mechanical ventilation time, ICU stay days, PSI score, NLRP3, Caspase-1 and IL-1β levels in death group were higher than those in survival group (P<0.05); Multiple Logistic regression analysis confirmed that longer mechanical ventilation time, PSI score, NLRP3, Caspase-1, IL-1β levels were risk factors for death in elderly patients with severe pneumonia was both (P<0.05); Confirmed by ROC analysis PSI score, NLRP3, Caspase 1, the level of IL-1 beta can be used to predict mortality risk of elderly patients with severe pneumonia was, the area under the curve were 0.678, 0.825, 0.744, 0.749, And the above factors combined prediction can be obtained under higher curve area is 0.966, both(P<0.05).

NLRP3 signaling pathways and related cytokine levels and risk of death of elderly patients with severe pneumonia was closely related to, joint PSI grading test can further improve the predictive value.