Through bibliometric statistical analysis and visual analysis of studies related to brain metastasis of lung cancer, this study aims to explore the research hotspots and development trends in this field over the past 10 years.

A total of 1, 349 Chinese-language articles and 3, 352 English-language articles were retrieved, of which 376 were related to immunotherapy for brain metastases from lung cancer. An overall analysis of the WOS database showed that the annual growth rate of English-language publications was 15.15%, involving 17, 814 authors and 53, 537 references. Based on the core database of CNKI and Web of Science, Citespace was used to explore the research hotspot and development trend of brain metastases related to lung cancer in recent 10 years through bibliometric statistics and visual analysis VOS viewer and R software conducted bibliometrics statistics and visual analysis of the published articles from 2014 to 2024, conducted visual analysis of the annual distribution and citation of the published articles, national and regional institutions and keywords, and conducted co-occurrence analysis of the keywords cluster analysis and emergence analysis.

Through the visual analysis of 1 349 CNKI and 3 352 WOS core database literature in the field of lung cancer brain metastasis, the number of papers published in this field showed an increasing trend year by year, China and United States ranked the top two in English, published 1, 224 and 887 articles, respectively, accounting for approximately 60% of the total publications of all countries in the past decade. Zhengzhou University and Hanvard University were the institutions with the largest number of Chinese and English articles, and the authors with the most Chinese and English literature output were Wu Yilong, Ahn and Myung-Ju, respectively, and keyword analysis suggested targeted therapy and chemotherapy, radiotherapy, immunotherapy and combination therapy are hot spots.

In the past 10 years, the field of lung cancer brain metastases has continued to develop, the change of treatment protocols has extended the survival time, and immunization and combination therapy have become the mainstream to break the therapeutic barrier. In the future, multidisciplinary integration will realize the precision treatment of lung cancer brain metastases.