Curative efficacy of high oxygen liquid of one lung ventilation anesthesia in children

doi:10.3877/cma.j.issn.1674-6902.2017.01.009

Abstract

Abstract:

Objective

To study curative efficacy of high oxygen liquid of one lung ventilation anesthesia in children.

Methods

30 children of one lung ventilation anesthesia who received therapy from July 2014 to July 2016 in our hospital were selected as research objects. According to random number table, all underwent pulmonary lobectomy, those children were divided into the A group (n=15) and the B group (n=15). The A group after one lung ventilation, was treated with the 30 ml (kg·h) speed, constant speed input acetated glygoyle liquid oxygen, while the B group was treated with acetated ringer liquid injected the same speed.Then intraoperative blood gas analysis and inflammatory factor changesand postoperative conditions were compared.

Results

The pH, arterial oxygen partial pressure (PaO₂), mixed venous oxygen partial pressure () and mixed venous oxygen saturation () in the two groups were decreased in different degrees in T0 (before ventilation), T1 (ventilation 10 min), T2 (ventilation 30 min), T3 (ventilation 60 min), T4 (ventilation 2 h)(P<0.05), but the levels of pH, PaO_2, , in A group were higher than the B group in T1, T2, T3, T4(P<0.05); the levels of tumor necrosis factor (TNF)-α, interleukin (IL) -6, IL-8, IL-10, malondialdehyde (MDA) in the T1, T2, T3, T4 compared with T0, were all increased in different degrees in the two groups(P<0.05), but the level of TNF-α, IL-6, IL-8, MDA in A group were lower than B group in T1, T2, T3, T4(P<0.05); the recovery time in A group was shorter than that the B group(P<0.05), the incidence rate of agitation was lower than the B group(P<0.05).

Conclusions

The constant input of acetated high oxygen liquid is well for one lung ventilation anesthesia in children, which can preventing the occurrence of hypoxia, reduce the inflammatory reaction, high security, it′s worthy of application and promotion.

Key words: High oxygen liquid, One-lung ventilation, Hypoxia, Blood gas analysis, Inflammatory factor

Hang Tian, Xinyu Li, Junxiang Huang, Yinyi Xu, Guantu Xie, Xiaohua Guo, Xingrong Song. Curative efficacy of high oxygen liquid of one lung ventilation anesthesia in children[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2017, 10(01): 41-45.

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References 22

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指　标	组别	T0	T1	T2	T3	T4
pH	A组	7.84±0.59	7.65±0.43^ab	7.58±0.32^ab	7.51±0.28^ab	7.49±0.34^ab
?	B组	7.88±0.54	7.39±0.34^a	7.31±0.31^a	7.25±0.26^a	7.21±0.24^a
PaO₂(mmHg)	A组	237.34±24.09	210.32±22.31^ab	184.35±17.84^ab	180.34±17.45^ab	174.51±15.12^ab
?	B组	240.12±23.45	188.34±21.56^a	145.32±15.34^a	132.12±14.34^a	127.34±14.83^a
(mmHg)	A组	53.41±8.45	48.54±7.81^a	44.50±7.56^ab	43.12±6.95^ab	42.83±7.12^ab
?	B组	53.47±8.34	42.93±7.64^a	38.94±7.41^a	36.87±7.13^a	35.73±7.02^a
(%)	A组	78.43±5.91	72.83±5.12^ab	69.09±4.83^ab	67.43±4.71^ab	66.83±4.60^ab
?	B组	78.59±5.72	69.65±4.85^a	64.12±4.76^a	62.10±4.31^a	60.84±4.20^a

指　标	组别	T0	T1	T2	T3	T4
pH	A组	7.84±0.59	7.65±0.43^ab	7.58±0.32^ab	7.51±0.28^ab	7.49±0.34^ab
?	B组	7.88±0.54	7.39±0.34^a	7.31±0.31^a	7.25±0.26^a	7.21±0.24^a
PaO₂(mmHg)	A组	237.34±24.09	210.32±22.31^ab	184.35±17.84^ab	180.34±17.45^ab	174.51±15.12^ab
?	B组	240.12±23.45	188.34±21.56^a	145.32±15.34^a	132.12±14.34^a	127.34±14.83^a
(mmHg)	A组	53.41±8.45	48.54±7.81^a	44.50±7.56^ab	43.12±6.95^ab	42.83±7.12^ab
?	B组	53.47±8.34	42.93±7.64^a	38.94±7.41^a	36.87±7.13^a	35.73±7.02^a
(%)	A组	78.43±5.91	72.83±5.12^ab	69.09±4.83^ab	67.43±4.71^ab	66.83±4.60^ab
?	B组	78.59±5.72	69.65±4.85^a	64.12±4.76^a	62.10±4.31^a	60.84±4.20^a

指　标	组别	T0	T1	T2	T3	T4
TNF-α(ng/L)	A组	13.02±2.30	17.43±2.49^ab	18.34±2.03^ab	18.54±2.33^ab	18.63±2.37^ab
?	B组	13.05±2.25	19.45±3.45^a	25.95±4.12^a	27.83±3.41^a	27.75±3.53^a
IL-6(ng/L)	A组	13.28±2.56	15.34±2.74^ab	16.03±2.83^ab	16.12±2.79^ab	16.38±2.95^ab
?	B组	13.30±2.51	17.84±3.01^a	19.83±3.15^a	21.23±3.20^a	21.33±3.62^a
IL-8(ng/L)	A组	6.78±1.24	7.38±1.30^a	7.52±1.42^ab	7.61±1.39^ab	7.65±1.34^ab
?	B组	6.81±1.20	8.95±1.68^a	10.34±2.08^a	12.45±2.51^a	13.02±2.93^a
IL-10(ng/L)	A组	20.31±4.03	27.84±5.14^ab	29.58±6.86^ab	32.85±7.43^ab	33.40±7.49^ab
?	B组	20.39±3.87	24.02±4.12^a	25.87±5.12^a	25.75±5.40^a	25.98±5.58^a
MDA(μmol/L)	A组	8.45±1.23	11.34±1.57^ab	12.03±1.68^ab	13.17±2.31^ab	14.03±2.41^ab
?	B组	8.48±1.20	14.93±2.05^a	17.84±2.43^a	19.08±3.23	20.94±3.67^a

指　标	组别	T0	T1	T2	T3	T4
TNF-α(ng/L)	A组	13.02±2.30	17.43±2.49^ab	18.34±2.03^ab	18.54±2.33^ab	18.63±2.37^ab
?	B组	13.05±2.25	19.45±3.45^a	25.95±4.12^a	27.83±3.41^a	27.75±3.53^a
IL-6(ng/L)	A组	13.28±2.56	15.34±2.74^ab	16.03±2.83^ab	16.12±2.79^ab	16.38±2.95^ab
?	B组	13.30±2.51	17.84±3.01^a	19.83±3.15^a	21.23±3.20^a	21.33±3.62^a
IL-8(ng/L)	A组	6.78±1.24	7.38±1.30^a	7.52±1.42^ab	7.61±1.39^ab	7.65±1.34^ab
?	B组	6.81±1.20	8.95±1.68^a	10.34±2.08^a	12.45±2.51^a	13.02±2.93^a
IL-10(ng/L)	A组	20.31±4.03	27.84±5.14^ab	29.58±6.86^ab	32.85±7.43^ab	33.40±7.49^ab
?	B组	20.39±3.87	24.02±4.12^a	25.87±5.12^a	25.75±5.40^a	25.98±5.58^a
MDA(μmol/L)	A组	8.45±1.23	11.34±1.57^ab	12.03±1.68^ab	13.17±2.31^ab	14.03±2.41^ab
?	B组	8.48±1.20	14.93±2.05^a	17.84±2.43^a	19.08±3.23	20.94±3.67^a

组　别	例数	拔管时间	苏醒时间	躁动[n(%)]
A组	15	14.85±1.58	41.23±3.04	1(6.67)
B组	15	14.74±1.60	54.78±5.12	6(40.00)
t(χ²)值	?	0.189	8.813	2.981
P值	?	0.851	0.000	0.084

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