Expression levels of Jun dimerization protein and Phf2 in patients with non-small cell lung cancer and their correlation with pathological features

doi:10.3877/cma.j.issn.1674-6902.2020.01.007

Abstract

Abstract:

Objective

To investigate the expression levels of Jun dimerization protein (JDP2) and Phf2 in the patients with non-small cell lung cancer (NSCLC) and to analyze their correlation with the pathological characteristics.

Methods

A total of 65 NSCLC specimens and the adjacent normal tissues of cancer collected from the pathologically-confirmed patients in our hospital from January 2018 to March 2019 were enrolled for this study. The baseline data including gender, age, BMI, tumor diameter, degree of differentiation, tumor metastasis, tumor stage, pathological type and three-year survival rate were collected. The expression levels of JDP2 and phf2 were detected by immunohistochemistry, and their correlation with the clinicopathological characteristics and the prognosis of NSCLC patients was analyzed.

Results

The positive expression rates of JDP2 and Phf2 in the adjacent normal tissues of cancer were higher than those of the cancer tissues (P<0.05). Spearman analysis showed that the expression levels of JDP2 and Phf2 in the NSCLC tissues were negatively correlated, and they had a synergistic effect (P<0.05). The positive expression rates of JDP2 and Phf2 in the NSCLC patients at Stage Ⅲ and with tumor metastasis were lower than those of the patients in Stage Ⅰ/Ⅱ and without tumor metastasis. Moreover, the positive expression rates of JDP2 and Phf2 in the patients with advanced differentiation of NSCLC were higher than those of the patients with low differentiation degree (P<0.05). During the 3-year follow-up period, 42 patients (64.62%) survived and 23 patients died (35.38%). The survival rates of the NSCLC patients with tumor diameter>3 cm, TNM stage Ⅲ, tumor metastasis, negative JDP2 and negative Phf2 were lower than the NSCLC patients with tumor diameter ≤3 cm, TNM stage Ⅰ/Ⅱ, no tumor metastasis, positive JDP2 and positive Phf2 (P<0.05).

Conclusion

The expression levels of JDP2 and Phf2 are lower in the NSCLC tissues and their expression levels are correlated with the tumor TNM stage, tumor metastasis and prognosis, which may provide a reference for early diagnosis and prognosis evaluation of the NSCLC patients.

Key words: Jun dimerization protein, Phf2, Non-small cell lung cancer, Expression, Pathological features, Correlation

Fengxiang Peng, Dan Li, Rongmei Gao, Yongchun Li, Xiaojuan Ye. Expression levels of Jun dimerization protein and Phf2 in patients with non-small cell lung cancer and their correlation with pathological features[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2020, 13(01): 34-38.

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Figures/Tables 5

References 26

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项　目	例数	+	构成比(%)	-	构成比(%)	χ²值	P值
JDP2						29.823	<0.001
癌旁组织	65	51	78.46	14	21.54
癌组织	65	20	30.77	45	69.23
Phf2						44.695	<0.001
癌旁组织	65	54	83.08	11	16.92
癌组织	65	16	24.62	49	75.38

项　目	例数	+	构成比(%)	-	构成比(%)	χ²值	P值
JDP2						29.823	<0.001
癌旁组织	65	51	78.46	14	21.54
癌组织	65	20	30.77	45	69.23
Phf2						44.695	<0.001
癌旁组织	65	54	83.08	11	16.92
癌组织	65	16	24.62	49	75.38

病理参数	类型	例数	存活	构成比(%)	死亡	构成比(%)
肿瘤直径/cm	≤3	33	26	78.79	7	21.21
	>3^a	32	16	50.00	16	50.00
分级程度	低级	26	17	65.38	9	34.62
	中级	21	14	66.67	7	33.33
	高级	18	11	61.11	7	38.89
肿瘤TNM分期	Ⅰ期	22	20	90.91	2	9.09
	Ⅱ期	19	12	63.16	7	36.84
	Ⅲ期^a	24	10	41.67	14	58.33
肿瘤转移	无	32	28	87.50	4	12.50
	有^a	33	14	42.42	19	57.58
JDP2	+	20	16	80.00	4	20.00
	-^a	45	26	57.78	19	42.22
Phf2	+	16	14	87.50	2	12.50
	-^a	49	28	57.14	21	42.86

病理参数	类型	例数	存活	构成比(%)	死亡	构成比(%)
肿瘤直径/cm	≤3	33	26	78.79	7	21.21
	>3^a	32	16	50.00	16	50.00
分级程度	低级	26	17	65.38	9	34.62
	中级	21	14	66.67	7	33.33
	高级	18	11	61.11	7	38.89
肿瘤TNM分期	Ⅰ期	22	20	90.91	2	9.09
	Ⅱ期	19	12	63.16	7	36.84
	Ⅲ期^a	24	10	41.67	14	58.33
肿瘤转移	无	32	28	87.50	4	12.50
	有^a	33	14	42.42	19	57.58
JDP2	+	20	16	80.00	4	20.00
	-^a	45	26	57.78	19	42.22
Phf2	+	16	14	87.50	2	12.50
	-^a	49	28	57.14	21	42.86

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