Effect of carbon dioxide partial pressure and lactic acid on prognosis of acute exacerbation of chronic obstructive pulmonary disease in elderly patients with blood gas analysis

doi:10.3877/cma.j.issn.1674-6902.2020.06.011

Abstract

Abstract:

Objective

To observe the effect of partial pressure of carbon dioxide(PaCO₂) and lactic acid on the prognosis of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) in elderly patients.

Methods

The clinical data of 150 elderly patients with AECOPD admitted to the Department of Respiratory Medicine from June 20 to June 2019 in Chongqing from the Thirteenth People′s Hospital of Chongqing were retrospectively analyzed. According to the prognosis, 15 patients were included in the death group and the survival group. In 135 cases, PaCO₂ and lactic acid were compared before and after treatment. The Pearson correlation analysis was used to test the correlation between the prognosis of AECOPD and PaCO₂ and lactic acid in blood gas analysis.

Results

There was no significant difference in PaCO₂ and lactic acid between the two groups before treatment (P>0.05). There was significant difference between the survival group and the treatment group before treatment (P<0.05). There was no statistical difference between the death group and the treatment group (P>0.05), the survival group was lower than the mortality rate, there was statistical difference (P<0.05); Pearson correlation analysis showed that the prognosis of elderly patients with AECOPD was negatively correlated with PaCO₂ and lactic acid (r=-0.56, -0.61, P<0.05).

Conclusion

PaCO₂ and lactic acid in blood gas analysis are negatively correlated with the prognosis of elderly patients with AECOPD. The higher the value, the worse the prognosis.

Key words: Old age, Acute exacerbation of chronic obstructive pulmonary disease, Blood gas analysis, Prognosis

Yali Xu, Wei Wang, Qi Yang, Jun Zhu. Effect of carbon dioxide partial pressure and lactic acid on prognosis of acute exacerbation of chronic obstructive pulmonary disease in elderly patients with blood gas analysis[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2020, 13(06): 769-772.

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References 21

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组　别	例数	PaCO₂(mmHg)		t值	P值	乳酸(mmol/L)		t值	P值
组　别	例数	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值
存活组	135	58.11±1.11	45.57±1.13	79.168	0.000	2.22±0.20	1.40±0.10	36.672	0.000
死亡组	15	58.14±1.14	60.20±1.20	4.343	0.079	2.25±0.22	2.30±0.25	1.501	0.135
t值		0.189	88.758	-	-	1.009	33.425	-	-
P值		0.851	0.000	-	-	0.314	0.000	-	-

组　别	例数	PaCO₂(mmHg)		t值	P值	乳酸(mmol/L)		t值	P值
组　别	例数	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值
存活组	135	58.11±1.11	45.57±1.13	79.168	0.000	2.22±0.20	1.40±0.10	36.672	0.000
死亡组	15	58.14±1.14	60.20±1.20	4.343	0.079	2.25±0.22	2.30±0.25	1.501	0.135
t值		0.189	88.758	-	-	1.009	33.425	-	-
P值		0.851	0.000	-	-	0.314	0.000	-	-

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