Clinical significance of dexmedetomidine in elderly patients with lung cancer and moderate chronic obstructive pulmonary disease

doi:10.3877/cma.j.issn.1674-6902.2021.01.016

Abstract

Maoqian Ding, Juan Liu, Ninghao Lyu. Clinical significance of dexmedetomidine in elderly patients with lung cancer and moderate chronic obstructive pulmonary disease[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2021, 14(01): 76-79.

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组　别	例数	时间	肺动态顺应性(ml/cm H₂O)	氧合指数(mmHg)	气道平台压(cm H₂O)	死腔通气量(ml)
右美托咪定组	40	T1	46.81±9.84	516.54±115.40	13.94±2.10	19.37±3.54
		T2	38.49±8.47^a	210.58±45.39^a	16.31±2.45^a	21.41±3.57^a
		T3	39.64±6.43^b	256.13±45.63^b	20.27±2.89^b	22.12±4.53^b
		T4	41.85±9.16^c	354.64±55.30^c	16.24±2.76^c	30.48±5.61^c
生理盐水组	41	T1	45.59±9.18	480.89±85.61	14.53±2.16	19.79±3.87
		T2	36.82±6.24	169.43±58.97	24.41±2.56	23.97±3.69
		T3	32.87±3.58	200.46±52.87	27.09±2.27	25.67±5.01
		T4	32.46±6.17	276.01±47.68	23.21±2.46	35.54±5.86

组　别	例数	时间	肺动态顺应性(ml/cm H₂O)	氧合指数(mmHg)	气道平台压(cm H₂O)	死腔通气量(ml)
右美托咪定组	40	T1	46.81±9.84	516.54±115.40	13.94±2.10	19.37±3.54
		T2	38.49±8.47^a	210.58±45.39^a	16.31±2.45^a	21.41±3.57^a
		T3	39.64±6.43^b	256.13±45.63^b	20.27±2.89^b	22.12±4.53^b
		T4	41.85±9.16^c	354.64±55.30^c	16.24±2.76^c	30.48±5.61^c
生理盐水组	41	T1	45.59±9.18	480.89±85.61	14.53±2.16	19.79±3.87
		T2	36.82±6.24	169.43±58.97	24.41±2.56	23.97±3.69
		T3	32.87±3.58	200.46±52.87	27.09±2.27	25.67±5.01
		T4	32.46±6.17	276.01±47.68	23.21±2.46	35.54±5.86

组　别	例数	时间	IL-6(pg/ml)	IL-8(pg/ml)	TNF-α(pg/ml)	CD4⁺/CD8⁺
右美托咪定组	40	T1	19.27±2.94	9.31±1.52	15.31±2.57	1.27±0.42
		T3	73.15±15.40^a	14.54±2.14^a	20.17±3.48^a	1.11±0.48^a
		T4	65.46±11.39^b	19.74±5.05^b	21.78±2.31^b	1.02±0.31^b
生理盐水组	41	T1	19.47±3.74	9.17±1.62	15.03±1.79	1.25±0.54
		T3	124.31±21.95	19.73±3.25	25.89±3.54	0.93±0.27
		T4	94.60±14.31	29.28±4.61	30.17±4.50	0.76±0.43

组　别	例数	时间	IL-6(pg/ml)	IL-8(pg/ml)	TNF-α(pg/ml)	CD4⁺/CD8⁺
右美托咪定组	40	T1	19.27±2.94	9.31±1.52	15.31±2.57	1.27±0.42
		T3	73.15±15.40^a	14.54±2.14^a	20.17±3.48^a	1.11±0.48^a
		T4	65.46±11.39^b	19.74±5.05^b	21.78±2.31^b	1.02±0.31^b
生理盐水组	41	T1	19.47±3.74	9.17±1.62	15.03±1.79	1.25±0.54
		T3	124.31±21.95	19.73±3.25	25.89±3.54	0.93±0.27
		T4	94.60±14.31	29.28±4.61	30.17±4.50	0.76±0.43

组　别	例数	时间	MPAP(mmHg)	sICAM-1(μg/L mmHg)
右美托咪定组	40	T1	33.67±6.61	150.62±15.12
		T2	17.44±1.87	174.32±25.06
		T3	10.31±1.51	191.90±23.87
		T4	7.36±1.46	231.24±23.97
生理盐水组	41	T1	32.71±6.57	144.89±20.45^a
		T2	23.36±1.91	163.54±21.16
		T3	16.80±1.86	183.37±23.48
		T4	10.28±1.99	245.81±25.05

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组　别	例数	恶心	呕吐	头痛	低氧血症	总发生率
右美托咪定组	40	1(2.50)	1(2.50)	2(5.00)	0(0.00)	4(10.00)
生理盐水组	41	2(4.89)	0(0.00)	1(2.44)	1(2.44)	4(9.76)
χ²值				0.001
P值				0.970

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