To systematically evaluate and analyze the clinical outcomes of extubation at different times when the drainage volume of lung cancer is less than 100 ml, 200 ml, 300 ml, 400 ml 24 hours after operation by using reticular Meta-analysis.

randomized controlled trial (RCT) of extubation at different times after lung cancer surgery was searched in PubMed, EMBASE, The Cochrane Library, Web of Science and Chinese databases Wanfang, CBM and CNKI. The search time was from the establishment of the database to November 2019. Two researchers conducted literature screening, data extraction and quality evaluation according to the inclusion criteria, and then used stata 14.0 and Review Manage software to conduct network Meta-analysis.

Through direct meta-analysis, the pleural effusion was 100 ml and 300 ml (RR: 0.41, 95%CI: 0.19~0.90, P=0.03). 100 ml of secondary catheter was compared with 300 ml (RR: 0.43, 95%CI: 0.19~0.97, P=0.04); 100 ml compared with 200 ml (MD: 1.70, 95%CI: 0.57~2.82, P=0.003); 100 ml compared with 300 ml (MD: 2.32, 95%CI: 1.31~3.33, P<0.001); 200 ml compared with 300 ml(MD: 1.68, 95%CI: 1.34~2.01, P<0.001).

The more pleural drainage fluid, the shortest hospitalization time after removing the tube, but the highest complications. When the thoracic drainage fluid is 100ml, the closed thoracic drainage tube is removed, and the complication rate is the lowest, but the hospitalization time is long. Therefore, according to the analysis of the final data in this paper, it is the best scheme to remove the pleural fluid when it is 150 ml.