Expression and detection significance of peripheral blood NLRP3, IL­18, and IL­1&#x03B2; in children with mycoplasmal pneumonia pneumonia

doi:10.3877/cma.j.issn.1674-6902.2023.06.026

Abstract

Lizhen Zhu, Wencui Fan, Mengyao Li. Expression and detection significance of peripheral blood NLRP3, IL18, and IL1β in children with mycoplasmal pneumonia pneumonia[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(06): 860-863.

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References 28

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组　别	例数	NLRP3 mRNA	IL-18(pg/ml)	IL-1β(pg/ml)
轻症组	53	1.73±0.15^a	159.25±21.42^a	5.42±0.84^a
重症组	37	2.19±0.23	212.46±25.33	8.56±1.23

组　别	例数	NLRP3 mRNA	IL-18(pg/ml)	IL-1β(pg/ml)
轻症组	53	1.73±0.15^a	159.25±21.42^a	5.42±0.84^a
重症组	37	2.19±0.23	212.46±25.33	8.56±1.23

组　别	例数	NLRP3 mRNA1.92		IL-18(pg/ml)181.13		IL-1β(pg/ml)6.71
组　别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
痊愈	36	1.69±0.18	1.21±0.16^a	155.14±18.56	113.57±14.75^a	5.21±0.43	2.86±0.26^a
好转	46	1.88±0.21^bc	1.53±0.24^abc	191.25±24.38^bc	132.45±23.56^abc	7.33±0.57^bc	4.65±0.32^abc
未愈	8	3.18±0.52^b	2.02±0.33^ab	239.90±27.53^b	172.56±25.53^ab	9.90±1.35^b	6.73±0.74^ab

组　别	例数	NLRP3 mRNA1.92		IL-18(pg/ml)181.13		IL-1β(pg/ml)6.71
组　别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
痊愈	36	1.69±0.18	1.21±0.16^a	155.14±18.56	113.57±14.75^a	5.21±0.43	2.86±0.26^a
好转	46	1.88±0.21^bc	1.53±0.24^abc	191.25±24.38^bc	132.45±23.56^abc	7.33±0.57^bc	4.65±0.32^abc
未愈	8	3.18±0.52^b	2.02±0.33^ab	239.90±27.53^b	172.56±25.53^ab	9.90±1.35^b	6.73±0.74^ab

预测指标	最佳截断值	敏感度(%)	特异度(%)	ACU	95%CI
NLRP3 mRNA	1.94	85.29	83.76	0.834	0.795～0.916
IL-18	197.65 pg/ml	82.39	80.98	0.817	0.757～0.895
IL-1β	7.38 ng/ml	81.79	78.62	0.789	0.724～0.883
联合	/	79.33	91.85	0.897	0.876～0.938

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Expression and detection significance of peripheral blood NLRP3, IL18, and IL1β in children with mycoplasmal pneumonia pneumonia