To compare the anesthetic effects of ciprofol and propofol in Da Vinci robotassisted lung cancer lobectomy.

A total of 113 patients who underwent Da Vinci robotassisted lung cancer lobectomy in our hospital from May 2022 to February 2025 were enrolled and randomly divided into a ciprofol group 57 cases and a propofol group 56 cases. The ciprofol group received a loading dose of 0.3~0.4 mg/kg ciprofol followed by continuous intravenous infusion at 0.8 mg/(kg·h) for maintenance, while the propofol group received a loading dose of 1.5~2.5 mg/kg propofol followed by continuous infusion at 5.0 mg/(kg·h). The two groups were compared in terms of intraoperative heart rate (HR), mean arterial pressure (MAP), systolic blood pressure (SBP), diastolic blood pressure (DBP), regional cerebral oxygen saturation (rSO₂), postoperative recovery time, orientation recovery time, MiniMental State Examination (MMSE) scores, and perioperative adverse reactions.

At 5 min after induction, MAP, SBP, and DBP in the ciprofol group were higher than those in the propofol group (P<0.05). At 15 min after anesthesia, there was no significant difference in rSO₂ between the two groups [(75.54±2.57)% vs. (75.84±2.62)%, P=0.565]; at 10, 30, and 60 min of onelung ventilation and at 20 min after resumption of twolung ventilation, rSO₂ in the ciprofol group was higher than that in the propofol group [(71.67±2.42)% vs. (69.54±2.37)%, (70.37±2.87)% vs. (68.29±4.35)%, (70.27±3.68)% vs. (66.31±2.13)%, (74.45±3.76)% vs. (71.21±2.71)%, all P<0.001]. The induction success time [(1.41±0.42) min vs. (1.59±0.58) min], spontaneous breathing recovery time [(10.96±1.57) min vs. (13.28±2.02) min], postoperative recovery time [(9.34±1.58) min vs. (11.57±1.82) min], and orientation recovery time [(16.35±2.53) min vs. (18.98±2.42) min] in the ciprofol group were shorter than those in the propofol group (all P<0.001). The MMSE scores at 3 h and 72 h after surgery in the ciprofol group were higher than those in the propofol group [(19.31±1.52) vs. (17.54±1.37), (25.90±1.04) vs. (23.31±1.13), P<0.001]; at 24 h after surgery, there was no significant difference between the two groups (P=0.711). There were no statistically significant differences between the two groups in the incidence of nausea and vomiting, intraoperative hypertension, hypotension, tachycardia, bradycardia, injection site pain, or postoperative delirium (POD) (P>0.05), POD 3 cases (5.36%) in the propofol group.

In Da Vinci robotassisted lung cancer lobectomy, ciprofol can better maintain intraoperative hemodynamic stability, increase cerebral oxygen saturation during onelung ventilation, shorten postoperative recovery and orientation recovery time, improve early cognitive function, and does not increase the risk of adverse reactions compared with propofol, demonstrating clinical significance.