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中华肺部疾病杂志(电子版) ›› 2017, Vol. 10 ›› Issue (03) : 292 -295. doi: 10.3877/cma.j.issn.1674-6902.2017.03.010

所属专题: 文献

论著

肺癌患者血清多效蛋白表达水平及其临床意义
张韶岩1, 曾小莉2,(), 区颂雷1, 马旭晨1   
  1. 1. 100029 北京,首都医科大学附属北京安贞医院胸外科
    2. 100029 北京,首都医科大学附属北京安贞医院检验科
  • 收稿日期:2016-11-01 出版日期:2017-06-20
  • 通信作者: 曾小莉
  • 基金资助:
    北京市卫生系统高层次卫生技术人才培养项目资助(NO. 2015-3-052)

Expression of pleiotrophin in serum and its clinical significance in patients with lung cancer

Shaoyan Zhang1, Xiaoli Zeng2,(), Songlei Ou1, Xuchen Ma1   

  1. 1. Department of Thoracic Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing100029, China
    2. Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing100029, China
  • Received:2016-11-01 Published:2017-06-20
  • Corresponding author: Xiaoli Zeng
  • About author:
    Corresponding author: Zeng Xiaoli, Email:
引用本文:

张韶岩, 曾小莉, 区颂雷, 马旭晨. 肺癌患者血清多效蛋白表达水平及其临床意义[J/OL]. 中华肺部疾病杂志(电子版), 2017, 10(03): 292-295.

Shaoyan Zhang, Xiaoli Zeng, Songlei Ou, Xuchen Ma. Expression of pleiotrophin in serum and its clinical significance in patients with lung cancer[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2017, 10(03): 292-295.

目的

探讨血清多效蛋白(PTN)在肺癌患者中的表达及其临床意义。

方法

采用ELISA检测57例非小细胞肺癌(NSCLC)患者、20例小细胞肺癌(SCLC)患者和12例正常对照组血清PIN水平,分析其对肺癌的诊断价值及与NSCLC病理分期和手术的关系。

结果

正常对照组PTN水平明显低于SCLC组(P<0.001)和NSCLC组(P=0.003),并且SCLC组PTN水平显著高于NSCLC组(P=0.010)。ROC曲线分析PTN对肺癌诊断的AUC为0.821(95%CI 0.730~0.913)(P<0.001);对NSCLC诊断的AUC为0.794(95%CI 0.684~0.904)(P=0.001);对SCLC诊断的AUC为0.900(95%CI 0.783~1.000)(P<0.001)。NSCLC患者PTN水平与病理分期(P<0.001)和肿瘤远处转移(P=0.019)密切相关,与病理类型和淋巴结转移无关(P>0.05)。NSCLC患者手术后PTN水平较手术前明显降低(P<0.001)。

结论

血清PTN可作为诊断肺癌的指标,PTN还可用于NSCLC病情监测和疗效判断。

Objective

To investigate the serum levels and clinical significance of the angiogenic factor pleiotrophin (PTN) in patients with lung cancer.

Methods

Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of PTN in 57 patients with non-small cell lung cancer (NSCLC), 20 patients with small cell lung cancer (SCLC) and 12 healthy individuals, and their relationship with pathological stage and operation therapy foe NSCLC was explored.

Results

PTN expression was significantly lower in healthy individuals than that in SCLC (P<0.001) and NSCLC patients (P=0.003). PTN level was significantly higher in SCLC patients than that in NSCLC patients (P=0.010). High expression of PTN was identified as a moderately specific marker for lung carcinoma distinguished from healthy subjects with the area under the ROC curve (AUC) at 0.821(95%CI 0.730~0.913) (P<0.001). Additionally, PTN was identified as a lowly specific marker for NSCLC distinguished from healthy subjects with AUC at 0.794 (95%CI 0.684~0.904) (P=0.001). However, PTN was identified as a highly specific marker for SCLC distinguished from healthy subjects with AUC at 0.900 (95%CI 0.783~1.000) (P<0.001). The PTN level in NSCLC patients was significantly associated with clinical stage (P<0.001) and distant metastasis (P=0.019). No association was found between PTN and other clinic pathological features such as pathological type and lymphatic metastasis in NSCLC patients. Compared with NSCLC patients before opertion, PTN level in NSCLC patients after operation was significantly decreased(P<0.001).

Conclusion

PTN in serum has the important values of diagnosing lung cancer. Moreover, PTN in serum can be available to estimate condition and curative effects of NSCLC.

图1 肺癌患者和正常对照血清PTN水平柱状图
图2 血清PTN诊断肺癌的ROC曲线图;注:A:血清PTN诊断肺癌的ROC曲线图和AUC;B:血清PTN诊断NSCLC的ROC曲线图和AUC;C:血清PTN诊断SCLC的ROC曲线图和AUC。
表1 NSCLC患者PTN水平与临床参数间的关系(±s)
表2 手术前后血清PTN水平变化(±s)
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