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中华肺部疾病杂志(电子版)

中华肺部疾病杂志(电子版) ›› 2017, Vol. 10 ›› Issue (03) : 296 -299. doi: 10.3877/cma.j.issn.1674-6902.2017.03.011

所属专题： 文献；

论著

特发性肺纤维化患者诱导痰中SDF-1的表达与高分辨CT表现的相关性研究
吴东1, 袁亚连1, 陈敏1, 李文1, 吕权超1, 黎东明1,†()   
  1. 1. 524001　湛江，广东医科大学附属医院呼吸疾病研究所·呼吸内科
  • 收稿日期:2017-03-20 出版日期:2017-06-20
  • 通信作者: 黎东明
  • 基金资助:
    广东省高校优秀青年创新人才培育基金项目(LYM09086)

Correlation between the high-resolution computed tomography parameters and levels of stromal cell-derived factor 1 in induced sputum of idiopathic pulmonary fibrosis patients

Dong Wu1, Yalian Yuan1, Min Chen1, Wen LI1, Quanchao Lv1, Dongming Li1,†()   

  1. 1. Institute of Respiratory Diseases, Department of Respiratory, The Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
  • Received:2017-03-20 Published:2017-06-20
  • Corresponding author: Dongming Li
  • About author:
    Corresponding author: Li Dongming, Email:
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引用本文：

吴东, 袁亚连, 陈敏, 李文, 吕权超, 黎东明. 特发性肺纤维化患者诱导痰中SDF-1的表达与高分辨CT表现的相关性研究[J]. 中华肺部疾病杂志(电子版), 2017, 10(03): 296-299.

Dong Wu, Yalian Yuan, Min Chen, Wen LI, Quanchao Lv, Dongming Li. Correlation between the high-resolution computed tomography parameters and levels of stromal cell-derived factor 1 in induced sputum of idiopathic pulmonary fibrosis patients[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2017, 10(03): 296-299.

目的

探讨特发性肺纤维化(IPF)患者血清和诱导痰中基质细胞衍生因子-1(SDF-1)的表达水平与肺功能及胸部高分辨CT表现的相关性。

方法

选取IPF患者32例及健康体检者30例，收集血清和诱导痰标本并检测SDF-1表达水平，IPF患者行肺功能和胸部高分辨CT检查，并对结果作相关分析。

结果

IPF患者的诱导痰中SDF-1的表达水平为(705.21±11.71)ng/ml，高于健康体检组的(252.82±10.62)ng/ml，P<0.05差异有统计学意义。血清中SDF-1的表达水平(5.29±0.13)ng/ml高于健康体检组的(4.93±0.14)ng/ml，但P>0.05，没有统计学意义。IPF患者肺功能均有限制性通气功能障碍和弥散功能障碍；影像学表现为程度不一的磨玻璃影、网格影和蜂窝肺，HRCT评分与诱导痰中的SDF-1表达水平呈正相关(r＝0.287，P<0.05)。

结论

SDF-1在IPF患者诱导痰中表达明显升高，并与患者病情严重程度(胸部高分辨CT表现)呈正相关，对IPF诊断和治疗具有潜在的参考价值。

关键词: 特发性肺纤维化, 基质细胞衍生因子-1, 肺功能, 高分辨CT
Objective

To evaluate concentrates of stromal cell-derived factor in serum and induced sputum supernatants from idiopathic pulmonary fibrosis(IPF) patients, investigate the relationship between the stromal cell-derived factor-1 (SDF-1) level and the high-resolution computed tomography parameters in patients and explore the role of SDF-1 in the diagnosis and treatment of IPF.

Methods

Serum and induced sputum samples were collected from 30 healthy controls and 32 patients with IPF. The concentrations of SDF-1 in serum and induced sputum were measured by ELISA. Lung function and chest high-resolution CT were executed in patients with IPF. Analysis of correlation was performed on these results.

Results

The concentration of SDF-1 in induced sputum was significantly increased in IPF group(705.21±11.71)ng/ml compared with healthy group(252.82±10.62)ng/ml(P<0.05). The level of SDF-1 in serum was also elevated in IPF patients(5.29±0.13)ng/ml compared with healthy group(4.93±0.14)ng/ml, but there was no statistically significant difference (P>0.05). All patients with IPF have restrictive ventilation dysfunction and diffusion dysfunction. There was a positive relationship between induced sputum SDF-1 level and HRCT score(r=0.287, P<0.01).

Conclusions

The expression of SDF-1 in induced sputum was significantly increased, and associated positively with severe degree (chest high-resolution CT manifestations) of patients with IPF. SDF-1 may play an important role in the pathogenesis of IPF, therefor serve as a potent testing index of the diagnosis and treatment of IPF.

Key words: Idiopathic pulmonary fibrosis, Stromal cell-derived factor-1, Lung function, High-resolution computed tomography
图1 SDF-1在两组血清和诱导痰中的表达水平
表1 两组的肺功能参数(±s)
参　数 FVC%预计值 FEV1%预计值 DLCO%预计值
健康体检者 108.58±11.03 98.67±13.56 101.23＋9.85
IPF患者 63.3±15.24 71.52±17.75 57.52＋20.15
图2 CT评分与诱导痰中SDF-1含量的相关性
图3 代表性病例：男性，59岁，因"进行性呼吸困难2年，加重10天"入院，经纤维支气管镜肺活检结果符合特发性肺纤维化改变；HRCT结果显示双肺弥漫性蜂窝样改变伴双下肺牵拉性支气管扩张；肺功能检查示中度限制性通气功能障碍和重度弥散功能障碍
1
崔社怀. 特发性肺间质纤维化的回顾和展望[J/CD]. 中华肺部疾病杂志(电子版), 2010, 3(1): 4-5.
2
Nakagawa H, Nagatani Y, Takahashi M, et al. Quantitative CT analysis of honeycombing area in idiopathic pulmonary fibrosis: Correlations with pulmonary function tests[J]. Eur J Radiol, 2016, 85(1): 125-130.
3
Nishiyama O, Tohda Y. Obstructive lung function in idiopathic pulmonary fibrosis[J]. Chron Respir Dis, 2016, 13(2): 206.
4
李文，吴东，梁标. 基质细胞衍生因子-1与肺纤维化关系的初步探讨[J]. 中国现代医学杂志，2008, 18(11): 1545-1547.
5
Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management[J]. Am J Respir Crit Care Med, 2011, 183(6): 788-824.
6
张红军，顾兴，刘伟，等. 特发性肺间质纤维化患者肿瘤标志物的特点分析[J/CD]. 中华肺部疾病杂志(电子版), 2016, 9(6): 621-624.
7
Vignola AM, Rennar SI, Hargreave FE, et al. Standardised methodology of sputum induction and processing. Future directions[J]．Eur Respir J Suppl, 2002, 37: 51s-55s.
8
Behr J, Demedts M, Buhl R, et al. Lung function in idiopathic pulmonary fibrosis-extended analyses of the IFIGENIA trial[J]. Respir Res, 2009, 10: 101.
9
吴友茹，陈明勇，朱静. 肺纤维化患者血清及诱导痰肺表面活性蛋白水平测定及意义[J]. 检验医学与临床，2015, 12(3): 350-351.
10
Juarez J, Bendall L, Bradstock K. Chemokines and their receptors as therapeutic targets: the role of the SDF-1/CXCR4 axis[J]. Curr Pharm Des, 2004, 10(11): 1245-1259.
11
王坤，赵沣凯，李彦林，等. T140体内靶向阻断SDF-1/CXCR4信号通路对SDF-1及MMPs的影响[J]. 实用医学杂志，2015, 31(19): 3133-3136.
12
Xu J, Mora A, Shim H, et al. Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis[J]. Am J Respir Cell Mol Biol, 2007, 37(3): 291-299.
13
李惠萍. 特发性肺纤维化的诊断和治疗[J]. 中华结核和呼吸杂志，2014, 37(9): 64.
14
郭晓娟，包娜，张镭，等. 特发性间质性肺炎高分辨率CT征象特点的量化比较分析[J]. 中华医学杂志，2011, 91(1): 11-15.
15
李文，吴东，罗伟仁. 姜黄素对哮喘大鼠肺内胶原沉积、结缔组织生长因子表达及气道重构的影响[J]. 实用医学杂志，2008, 24(15): 2562-2564.
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