探讨血清总免疫球蛋白E (TIgE)、嗜酸性粒细胞阳离子蛋白(ECP)水平在过敏性哮喘诊断中的意义，为哮喘患者防治方案的个体化、具体化提供客观依据。

采用自动化快速检测系统(CAP)对90例哮喘患者进行6种吸入性、12种食入性混合过敏原特异性IgE(SIgE)及TIgE、ECP检测。

①90例哮喘患者中过敏原总阳性率为68.89%，其中吸入性过敏原阳性率为58.89%，食入性过敏原阳性率为38.89%；②吸入混合过敏原中以Wx3(蒿属、车前草、藜属、一枝黄花、荨麻)及Hx2(屋尘、尘螨、粉瞒、蟑螂)占多数，食物以Fx3(小麦、燕麦、玉米、芝麻、荞麦)、Fx5(蛋白、牛奶、鳕鱼、花生、黄豆)占多数；③TIgE阳性率为64.44%，大多数哮喘患者以1～3种混合过敏原为主，过敏原种数、ECP水平与TIgE显著相关。过敏原种数与ECP无显著相关性。SIgE阳性组的血清TIgE明显高于SIgE阴性组，P<0.01。SIgE阳性组的血清ECP与SIgE阴性组相比无明显差异，P>0.05。

蒿属、藜属类植物为就诊于我院哮喘患者导致支气管哮喘发作最主要的变应原，混合型过敏原为初步筛选患者主要的过敏种类，若筛查阳性可进一步进行单项过敏原测定。TIgE可以用来提示过敏的概率，并帮助医师决定是否对一组常见吸入性过敏原试验阴性的患者作进一步检查。ECP检测不能判断患者的过敏状态。过敏原检测在哮喘疾病的预防和治疗中起着重要作用，检测变应原对特异性免疫治疗具有重要的指导意义。

To investigate the allergens categories of adult with asthma and provide scientific basis for its prevention and treatment. To investigate the diagnostic value of serum total immunoglobin E(TIgE) test and eosinophil cationic protein in asthma.

Ninty patients with asthma were detected the reactions to 6 kind of inhalation and 12 kind of ingestion of the mixed-allergen-specific IgE(SIgE) and total immunoglobin E(TIgE) using rapid automated detection system (CAP).

①In 90 asthma patients, allergens total positive rate was 68.89%, the inhaled allergens positive rate was 58.89%, eating allergen positive rate was 38.89%; ②the majority of mixed inhaled allergens are Wx3 (artemisia, plantago, chenopodium genus, solidago, urtica) and Hx2(house dust, dust mites, flour hiding, cockroaches), the majority of mixed food allergens are Fx3 (wheat, oats, corn, sesame, buckwheat), Fx5(protein, milk, cod fish, peanuts, soybeans); ③TIgE positive rate was 64.44%, the majority of patients with asthma were with 1-3 main mixed allergens. Type, ECP levels were correlated with TIgE. Allergen type has no significant correlation with ECP. Serum TIgE in SIgE positive group was significantly higher than SIgE negative group, P<0.01. Compared with SIgE negative group, ECP was no significant difference with SIgE positive group, P>0.05.

Wx3(artemisia, plantago, chenopodiumgenus, solidago, urtica)is the most important mixed allergens of bronchial asthma in Xinjiang. Mixed allergen initial screen the major types of allergens in patients. If screen positive, the individual allergens can be further determined. When the result was negative in common inhalant allergens test, TIgE can be used to suggest the probability of allergies, and help doctors decide whether a group of patients need further examination. ECP can not judge allergies in patients. The results may provide the guideline to specific immunity therapy (desensitization treatment).