切换至 "中华医学电子期刊资源库"

中华肺部疾病杂志(电子版) ›› 2020, Vol. 13 ›› Issue (01) : 69 -71. doi: 10.3877/cma.j.issn.1674-6902.2020.01.014

短篇论著

硫酸庆大霉素联合布地奈德溶液雾化吸入治疗急性支气管炎107例疗效观察
陈先华1, 刘引1, 杨陵1, 宋洁1, 许思权1, 王海晶2, 朱科1,(), 刘灵1,()   
  1. 1. 400038 重庆,陆军(第三)军医大学第一附属医院军人诊疗中心
    2. 400038 重庆,陆军(第三)军医大学第一附属医院呼吸科
  • 收稿日期:2019-11-06 出版日期:2020-02-25
  • 通信作者: 朱科, 刘灵
  • 基金资助:
    陆军军医大学临床科研基金资助项目(2018XLC3020); 陆军军医大学人文社科基金资助项目(2018XRW22)

Observation on the efficacy of gentamicin sulfate combined with budesonide solution atomization inhalation in the treatment of 107 cases of acute bronchitis

Xianhua Chen1, Yin Liu1, Ling Yang1   

  • Received:2019-11-06 Published:2020-02-25
引用本文:

陈先华, 刘引, 杨陵, 宋洁, 许思权, 王海晶, 朱科, 刘灵. 硫酸庆大霉素联合布地奈德溶液雾化吸入治疗急性支气管炎107例疗效观察[J]. 中华肺部疾病杂志(电子版), 2020, 13(01): 69-71.

Xianhua Chen, Yin Liu, Ling Yang. Observation on the efficacy of gentamicin sulfate combined with budesonide solution atomization inhalation in the treatment of 107 cases of acute bronchitis[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2020, 13(01): 69-71.

表1 两组患者治疗前后肺功能比较(±s)
表2 治疗组与对照组临床表现及治疗时间比较(±s)
1
Wark P. Bronchitis (acute) [J]. BMJ Clin Evid, 2015: pii: 1508.
2
Kinkade S, Long NA. Acute Bronchitis[J]. Am Fam Physician, 2016, 94(7): 560-565.
3
Albert RH. Diagnosis and treatment of acute bronchitis[J]. Am Fam Physician, 2010, 82(11): 1345-1350.
4
Little P, Rumsby K, Kelly J, et al. Information leaflet and antibiotic prescribing strategies for acute lower respiratory tract infection: a randomized controlled trial[J]. JAMA, 2005, 293(24): 3029-3035.
5
Linder JA, Sim I. Antibiotic treatment of acute bronchitis in smokers:a systematic review[J]. J Gen Intern Med, 2002, 17(3): 230-234.
6
Brereton CJ, Lennon D, Browning S, et al. Is gentamicin safe and effective for severe community-acquired pneumonia? An 8-year retrospective cohort study[J]. Int J Antimicrob Agents, 2018, 51(6): 862-866.
7
Hayward RS, Harding J, Molloy R, et al. Adverse effects of a single dose of gentamicin in adults: a systematic review[J]. Br J Clin Pharmacol, 2018, 84(2): 223-238.
8
Gyetvai B, Jerzsele Á, Pászti-Gere E, et al. Gentamicin sulphate permeation through porcine intestinal epithelial cell monolayer[J]. Acta Vet Hung, 2015, 63(1): 60-68.
9
McKenzie HC 3rd, Murray MJ, Concentrations of gentamicin in serum and bronchial lavage fluid after intravenous and aerosol administration of gentamicin to horses[J]. Am J Vet Res, 2000, 61(10): 1185-1190.
10
Lin HC, Cheng HF, Wang CH, et al. Inhaled gentamicin reduces airway neutrophil activity and mucus secretion in bronchiectasis[J]. Am J Respir Crit Care Med, 1997, 155(6): 2024-2029.
11
Park SW, Park JS, Lee YM, et al. Differences in radiological/HRCT findings in eosinophilic bronchitis and asthma: implication for bronchial responsiveness[J]. Thorax, 2006, 61(1): 41-47.
12
Zhang Y, Zhang ZR. Simple determination of terbutaline in dog plasma by column-switching liquid chromatography[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2004, 805(2): 211-214.
13
Hvizdos KM, Jarvis B. Budesonide inhalation suspension: a review of its use in infants, children and adults with inflammatory respiratory disorders[J]. Drugs, 2000, 60(5): 1141-1178.
14
Bian F, Wu YE, Zhang CL. Use of aerosol inhalation treatment with budesonide and terbutaline sulfate on acute pediatric asthmatic bronchitis[J]. Exp Ther Med, 2017, 14(2): 1621-1625.
15
Hashemian SM, Mortaz E, Jamaati H, et al. Budesonide facilitates weaning from mechanical ventilation in difficult-to-wean very severe COPD patients: Association with inflammatory mediators and cells[J]. J Crit Care, 2018, 44: 161-167.
16
Wenzel S, Castro M, Corren J, et al. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting beta2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial[J]. Lancet, 2016, 388(10039): 31-44.
17
Selek H, Sahin S, Ercan MT, et al. Formulation and in vitro/in vivo evaluation of terbutaline sulphate incorporated in PLGA (25/75) and L-PLA microspheres[J]. J Microencapsul, 2003, 20(2): 261-271.
18
Baer B, Veldhuizen EJA, Possmayer F, et al. The wet bridge transfer system: a novel tool to assess exogenous surfactant as a vehicle for intrapulmonary drug delivery[J]. Discov Med, 2018, 26(144): 207-218.
19
Edsbäcker S1, Brattsand R. Budesonide fatty-acid esterification: a novel mechanism prolonging binding to airway tissue. Review of available data[J]. Ann Allergy Asthma Immunol, 2002, 88(6): 609-616.
20
Jendbro M, Johansson CJ, Strandberg P, et al. Pharmacokinetics of budesonide and its major ester metabolite after inhalation and intravenous administration of budesonide in the rat[J]. Drug Metab Dispos, 2001, 29(5): 769-776.
21
Brattsand R, Miller-Larsson A. The role of intracellular esterification in budesonide once-daily dosing and airway selectivity[J]. Clin Ther, 2003, 25 Suppl C: C28-C41.
22
Miller-Larsson A, Jansson P, Runström A, et al. Prolonged airway activity and improved selectivity of budesonide possibly due to esterification[J]. Am J Respir Crit Care Med, 2000, 162(4 Pt 1): 1455-1461.
23
Sosnowski TR. Selected Engineering and Physicochemical Aspects of Systemic Drug Delivery by Inhalation[J]. Curr Pharm Des, 2016, 22(17): 2453-2462.
24
Hu X, Yang FF, Liao YH. Pharmacokinetic Considerations of Inhaled Pharmaceuticals for Systemic Delivery[J]. Curr Pharm Des, 2016, 22(17): 2532-2548.
25
Miller-Larsson A, Mattsson H, Hjertberg E, et al. Reversible fatty acid conjugation of budesonide. Novel mechanism for prolonged retention of topically applied steroid in airway tissue[J]. Drug Metab Dispos, 1998, 26(7): 623-630.
26
van Velzen AJ, Uges JWF, Heijerman HGM, et al. Pharmacokinetics and safety of tobramycin nebulization with the I-neb and PARI-LC Plus in children with cystic fibrosis: A randomized, crossover study[J]. Br J Clin Pharmacol, 2019, 85(9): 1984-1993.
27
韩振华. 超声雾化与空气压缩雾化泵雾化吸入治疗小儿哮喘的临床观察[J]. 山西医药杂志,2011, 40(02): 165-166.
28
Coates AL, Green M, Leung K, et al. A comparison of amount and speed of deposition between the PARI LC STAR(R) jet nebulizer and an investigational eFlow(R) nebulizer[J]. J Aerosol Med Pulm Drug Deliv, 2011, 24(3): 157-163.
29
陈先华. 硫酸庆大霉素雾化吸入佐治急性支气管炎的临床疗效观察[J/CD]. 中华肺部疾病杂志(电子版), 2012, 5(2): 133-136.
[1] 葛瑜, 李建木, 冯玲玲, 杨凡. 布地奈德联合重组人干扰素α-1b治疗急性婴幼儿毛细支气管炎的临床疗效[J]. 中华妇幼临床医学杂志(电子版), 2021, 17(03): 298-304.
[2] 刘雪茹, 王艳丽, 陈和斌, 陆小霞. 儿童感染后闭塞性细支气管炎临床分析[J]. 中华妇幼临床医学杂志(电子版), 2020, 16(05): 597-601.
[3] 杨梅, 周春, 赵艾红, 王琴. 儿童难治性肺炎支原体肺炎所致塑型性支气管炎风险列线图模型的构建[J]. 中华实验和临床感染病杂志(电子版), 2023, 17(04): 274-281.
[4] 丁晓静, 张丹琦, 杨伟. 布地奈德雾化吸入联合金嗓开音胶囊治疗小儿急性喉炎的疗效及对IFN-γ、SAA、IL-6的影响[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 391-393.
[5] 张晓娟, 邓祥瑞, 陈睿, 钟文. AECOPD伴肺部感染吸入三联疗效与EOS相关性分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 364-366.
[6] 李德莲, 杨鹏, 王琳. FeNO联合总IgE、CXCL13检测对儿童支气管炎继发哮喘的意义[J]. 中华肺部疾病杂志(电子版), 2022, 15(06): 838-840.
[7] 李玲, 于艳艳, 王玉杰, 赵凯. 毛细支气管炎患儿血清25(OH)D水平与Th17/Treg平衡的关系[J]. 中华肺部疾病杂志(电子版), 2022, 15(05): 718-720.
[8] 杨丽蓉, 彭才君, 章燕. rh-INFα2b雾化吸入联合沙丁胺醇治疗儿童毛细支气管炎的临床分析[J]. 中华肺部疾病杂志(电子版), 2022, 15(03): 373-375.
[9] 厉兰, 刘文春, 王安琪, 彭贻界. 多索茶碱联合氨溴索对小儿喘息性支气管炎的疗效及EOS的影响[J]. 中华肺部疾病杂志(电子版), 2022, 15(03): 430-431.
[10] 谢楚杏, 张月娥, 刘国军, 刘芬, 莫惠如, 戴金星, 赖茂. 呼出气一氧化氮联合特异性体质对毛细支气管炎患儿的预后意义[J]. 中华肺部疾病杂志(电子版), 2021, 14(03): 328-331.
[11] 黄赞胜, 吴显立, 郭洁茹, 王爽, 王苹, 张明周, 梁军, 范晔. 支气管扩张剂雾化吸入在支气管镜检查患者肺功能保护中的临床应用[J]. 中华肺部疾病杂志(电子版), 2020, 13(06): 742-745.
[12] 何丽, 吴至凤, 肖静. 3%高渗盐水联合沙丁胺醇雾化吸入治疗毛细支气管炎疗效的Meta分析[J]. 中华肺部疾病杂志(电子版), 2020, 13(05): 669-672.
[13] 王斌, 胡明冬, 徐静, 张椿, 陈华萍, 王关嵩, 徐智, 李琦. 诱导痰细胞分类在嗜酸细胞性支气管炎诊断和治疗中的应用[J]. 中华肺部疾病杂志(电子版), 2020, 13(04): 466-469.
[14] 欧婉婷, 雷克竞, 唐国红, 张本金. 毛细支气管炎患儿胸腺基质淋巴细胞生成素的表达水平与复发性喘息的相关性分析[J]. 中华肺部疾病杂志(电子版), 2020, 13(02): 193-197.
[15] 杨俊俊, 徐兴祥, 王正东, 邹晶. 原发性纤毛运动障碍一例[J]. 中华肺部疾病杂志(电子版), 2019, 12(04): 531-533.
阅读次数
全文


摘要